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Cited by 160

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Molecularly Engineering Triptolide with Aptamers for High Specificity and Cytotoxicity for Triple-Negative Breast Cancer

He, Jiaxuan, Peng, Tianhuan, Peng, Yongbo, Ai, Lili, Deng, Zhengyu, Wang, Xue-Qiang, Tan, Weihong·2020·Journal of the American Chemical Society
DOI 10.1021/jacs.9b10510
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Abstract

Triple-negative breast cancer (TNBC) lacks three important receptors, ER, PR, and HER2. It is more aggressive and more likely to relapse after treatment, thus has been identified as one of the most malignant breast cancer types. The development of efficient targeted TNBC therapy is an important research topic in TNBC treatment. We report the development of a new aptamer-drug conjugate (ApDC), AS1411-triptolide conjugate (ATC), as targeted therapy for the treatment of TNBC with high efficacy. The conjugate possesses excellent specificity and high cytotoxicity against the MDA-MB-231 cell line. The advantages of our newly invented ATC are further highlighted by its excellent in vivo anti-TNBC efficacy and negligible side effects toward healthy organs.

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Research works printed but not linked: 35

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Metadata

Authors
He, J., Peng, T., Peng, Y., Ai, L., Deng, Z., Wang, X.-Q., & Tan, W.
Venue
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Published
2020-01-07
Volume
142
Issue
6
Pages
2699-2703
ISSN
  • 0002-7863
  • 1520-5126
DOI
10.1021/jacs.9b10510
Cited by
160
References
0
Language
en
Licence
Funders
  • National Natural Science Foundation of China (21804037, 21827811, 61527806)
  • Science and Technology Project of Hunan Province (2017XK2103)

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