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Rhodium(I) Complex-Based Polymeric Nanomicelles in Water Exhibiting Coexistent Near-Infrared Phosphorescence Imaging and Anticancer Activity in Vivo
Open accessAbstract
Metal complexes that exhibit both near-infrared (NIR) phosphorescence imaging and chemotherapeutic activity would represent a novel class of anticancer drugs in clinical tumor treatment. In this work, a series of novel rodlike nanomicelles have been fabricated in water by coupling poly(ethylene oxide)- block -poly(sodium acrylate) and [Rh(C≡N-2,6-xylyl) 4 ] + ( 1 / 2 SO 4 ) − . These nanomicelles exhibit intense NIR phosphorescence and excellent stability. As revealed by in vivo NIR phosphorescence imaging data, the rodlike nanomicelle can selectively stain tumor sites with a long retention time. Moreover, the nanorods demonstrate effective anticancer activity by precisely killing tumor tissues without damaging healthy organs in vivo. To the best of our knowledge, this research provides the first example of metal-based complexes showing simultaneous NIR luminescence imaging and antitumor activity in vivo.
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In the citing paper
“Wang et al. prepared a series of new rodlike nanomicelles based on poly(ethylene oxide)-block-poly(sodium acrylate) [194].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [194]
In the citing paper
“As demonstrated by in vivo NIR imaging result, the rodlike nanomicelles can successfully stain cancer sites with a long retention time.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [194]
In the citing paper
“Moreover, the nanomicelles exhibited effective anticancer efficiency by accurately killing cancer cells without affecting healthy organs in vivo.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [194]
In the citing paper
“These nanomicelles displayed high NIR emission and strong stability.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [194]
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Metadata
- Authors
- Wang, J., Nie, J.-J., Guo, P., Yan, Z., Yu, B., & Bu, W.
- Affiliations
- State Key Laboratory of Applied Organic Chemistry (CN)
- State Key Laboratory of Chemical Resource Engineering (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Yu, Bingran
- Bu, Weifeng
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-01-30
- Volume
- 142
- Issue
- 6
- Pages
- 2709-2714
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W3003687332
- Cited by
- 66
- References
- 45
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 7 · 2020: 4
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- green
- ir.lzu.edu.cn
- Licence
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- Lanzhou University Institutional Repository (submittedVersion, cc-by-nc-sa)
- Lanzhou University Institutional Repository (submittedVersion)
- Funders
- State Key Laboratory of Polymer Physics and Chemistry (2018-25)
- State Key Laboratory of Supramolecular Structure and Materials (sklssm201903)
- National Natural Science Foundation of China (21474044, 21674044)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Keywords
- rhodium(I) complexes, polymeric micelles, anticancer activity, tumor targeting, in vivo tumor imaging, anticancer agents
- MeSH terms
- Animals, Antineoplastic Agents, Mice, Nude, Micelles, Polymers, Rhodium, Water, Spectroscopy, Near-Infrared, Xenograft Model Antitumor Assays, Nanostructures, Luminescence, Mice, Coordination Complexes
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