The DOI matches its Crossref record.
Inhibitory Effect of Caffeic Acid Phenethyl Ester on Angiogenesis, Tumor Invasion, and Metastasis
Abstract
Caffeic acid phenethyl ester (CAPE) derived from honeybee propolis has been used as a folk medicine and has several proven biological activities. The present study investigated the effect of CAPE on angiogenesis, tumor invasion, and metastasis. A cytotoxicity assay of CAPE in CT26 colon adenocarcinoma cells showed a dose-dependent decrease in cell viability but no significant influence on the growth of human umbilical vein epithelial cells (HUVEC). A low concentration of CAPE (1.5 microg/mL) inhibited 52.7% of capillary-like tube formation in HUVEC culture on Matrigel. CAPE (6 microg/mL)-treated CT26 cells showed not only inhibited cell invasion by 47.8% but also decreased expression of matrix metalloproteinase (MMP)-2 and -9. Vascular endothelial growth factor (VEGF) production from CT26 cells was also inhibited by treatment with CAPE (6 microg/mL). Intraperitoneal injection of CAPE (10 mg/kg/day) in BALB/c mice reduced the pulmonary metastatic capacity of CT26 cells accompanied with a decreased plasma VEGF level. CAPE treatment also prolonged the survival of mice implanted with CT26 cells. These results indicate that CAPE has potential as an antimetastatic agent.
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Cited by
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Weis, S. M., & Cheresh, D. A. (2005) · Nature · doi:10.1038/nature03987 · Cited by 909
Weng, C.-J., & Yen, G.-C. (2012) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2011.03.001 · Cited by 485
A Review of the Effects and Mechanisms of Polyphenolics in Cancer
Nichenametla, S. N., Taruscio, T. G., Barney, D. L., & Exon, J. H. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390591000541 · Cited by 444
Chemosensitization and Radiosensitization of Tumors by Plant Polyphenols
Garg, A. K., Buchholz, T. A., & Aggarwal, B. B. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1630 · Cited by 278
International registries of families at high risk of pancreatic cancer
Greenhalf, W., Malats, N., Nilsson, M., Bartsch, D., & Neoptolemos, J. (2008) · Pancreatology · doi:10.1159/000159843 · Cited by 85
Strategies for elevating hematopoietic stem cells expansion and engraftment capacity
Derakhshani, M., Abbaszadeh, H., Movassaghpour, A. A., Mehdizadeh, A., Ebrahimi-Warkiani, M., & Yousefi, M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116598 · Cited by 28
Metadata
- Authors
- Liao, H.-F., Chen, Y.-Y., Liu, J.-J., Hsu, M.-L., Shieh, H.-J., Liao, H.-J., Shieh, C.-J., Shiao, M.-S., & Chen, Y.-J.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-11-26
- Volume
- 51
- Issue
- 27
- Pages
- 7907-7912
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1984642803
- Cited by
- 202
- References
- 0
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- closed
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