The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.
A Review of the Effects and Mechanisms of Polyphenolics in Cancer
Abstract
This paper is a comprehensive review of the effects of bioactive polyphenolic compounds commonly found in many fruits and vegetables on cancer. These include the pheniolic acids, anthocyanins, catechins, stilbenes and several other flavonoids. We have attempted to compile information from most of the major studies in this area into one source. The review encompasses the occurrence and bioavailability of the polyphenolics, the in vitro and in vivo evidence for their effects on cancer, both positive and negative, and the various mechanisms by which the chemicals may exert their effects. Although most of the work done to date indicates a chemopreventative activity of these compounds, there are some studies that show cancer-inducing or no effects. There are several common mechanisms by which these chemicals exert their effects that could be conducive to additive, synergistic, or antagonistic interactions. These include effects on cellular differentiation, proliferation, and apoptosis, effects on proteins and enzymes that are involved in these processes at a molecular level, and other various effects through altered immune function and chemical metabolism.
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Cites
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Cited by
Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties
Dai, J., & Mumper, R. J. (2010) · Molecules · doi:10.3390/molecules15107313 · Cited by 4,506
Flavan‐3‐ols: Nature, occurrence and biological activity
Aron, P. M., & Kennedy, J. A. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700137 · Cited by 770
Anthocyanin food colorant and its application in pH-responsive color change indicator films
Roy, S., & Rhim, J.-W. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1776211 · Cited by 592
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Recent advances in the extraction of bioactive compounds with subcritical water: A review
Zhang, J., Wen, C., Zhang, H., Duan, Y., & Ma, H. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.11.018 · Cited by 485
Metadata
- Authors
- Nichenametla, S. N., Taruscio, T. G., Barney, D. L., & Exon, J. H.
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2006-03
- Volume
- 46
- Issue
- 2
- Pages
- 161-183
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W2120730389
- Cited by
- 444
- References
- 230
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nichenametla, S. N., Taruscio, T. G., Barney, D. L., & Exon, J. H. (2006). A Review of the Effects and Mechanisms of Polyphenolics in Cancer. Critical Reviews in Food Science and Nutrition. https://doi.org/10.1080/10408390591000541
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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