The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Pomegranate Juice, Total Pomegranate Ellagitannins, and Punicalagin Suppress Inflammatory Cell Signaling in Colon Cancer Cells
Abstract
Phytochemicals from fruits such as the pomegranate (Punica granatum L) may inhibit cancer cell proliferation and apoptosis through the modulation of cellular transcription factors and signaling proteins. In previous studies, pomegranate juice (PJ) and its ellagitannins inhibited proliferation and induced apoptosis in HT-29 colon cancer cells. The present study examined the effects of PJ on inflammatory cell signaling proteins in the HT-29 human colon cancer cell line. At a concentration of 50 mg/L PJ significantly suppressed TNFalpha-induced COX-2 protein expression by 79% (SE = 0.042), total pomegranate tannin extract (TPT) 55% (SE = 0.049), and punicalagin 48% (SE = 0.022). Additionally, PJ reduced phosphorylation of the p65 subunit and binding to the NFkappaB response element 6.4-fold. TPT suppressed NFkappaB binding 10-fold, punicalagin 3.6-fold, whereas ellagic acid (EA) (another pomegranate polyphenol) was ineffective. PJ also abolished TNFalpha-induced AKT activation, needed for NFkappaB activity. Therefore, the polyphenolic phytochemicals in the pomegranate can play an important role in the modulation of inflammatory cell signaling in colon cancer cells.
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Cites
Afaq, F., Saleem, M., Krueger, C. G., Reed, J. D., & Mukhtar, H. (2005) · International Journal of Cancer · doi:10.1002/ijc.20587 · Cited by 439
Cited by
Lansky, E. P., & Newman, R. A. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.09.006 · Cited by 1,290
Pomegranate and its many functional components as related to human health: a review
Viuda‐Martos, M., Fernández‐López, J., & Pérez‐Álvarez, J. A. (2010) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2010.00131.x · Cited by 768
Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways
Ramos, S. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700326 · Cited by 696
The gut microbiota: a key factor in the therapeutic effects of (poly)phenols
Espín, J. C., González-Sarrías, A., & Tomás-Barberán, F. A. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.04.033 · Cited by 603
Pomegranate: Botany, Horticulture, Breeding
Holland, D., Hatib, K., & Bar‐Ya'akov, I. (2009) · Horticultural Reviews · doi:10.1002/9780470593776.ch2 · Cited by 498
Metadata
- Authors
- Adams, L. S., Seeram, N. P., Aggarwal, B. B., Takada, Y., Sand, D., & Heber, D.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-01-13
- Volume
- 54
- Issue
- 3
- Pages
- 980-985
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2001633855
- Cited by
- 529
- References
- 1
- FWCI
- 15.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Adams, L. S., Seeram, N. P., Aggarwal, B. B., Takada, Y., Sand, D., & Heber, D. (2006). Pomegranate Juice, Total Pomegranate Ellagitannins, and Punicalagin Suppress Inflammatory Cell Signaling in Colon Cancer Cells. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf052005r
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
