The gut microbiota: a key factor in the therapeutic effects of (poly)phenols

Metagenomic Analysis of the Human Distal Gut Microbiome

Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699 · see citing works

Cross-talk between <i>Akkermansia muciniphila</i> and intestinal epithelium controls diet-induced obesity

Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219 · see citing works

The Human Intestinal Microbiome in Health and Disease

Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637 · see citing works

The gut microbiota, bacterial metabolites and colorectal cancer

Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,836 · see citing works

The gut microbiota and host health: a new clinical frontier

Marchesi, J. R., Adams, D. H., Fava, F., Hermes, G. D. A., Hirschfield, G. M., Hold, G., Quraishi, M. N., Kinross, J., Smidt, H., Tuohy, K. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309990 · Cited by 2,302 · see citing works

Diet–microbiota interactions as moderators of human metabolism

Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257 · see citing works

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204 · see citing works

The Mass Production of Redundant, Misleading, and Conflicted Systematic Reviews and Meta‐analyses

IOANNIDIS, J. P. A. (2016) · The Milbank Quarterly · doi:10.1111/1468-0009.12210 · Cited by 1,483 · see citing works

Interaction between Phenolics and Gut Microbiota: Role in Human Health

Selma, M. V., Espín, J. C., & Tomás-Barberán, F. A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902107d · Cited by 1,324 · see citing works

Phenolic compounds and related enzymes as determinants of quality in fruits and vegetables

Tomás-Barberán, F. A., & Espı́n, J. C. (2001) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.885 · Cited by 1,289 · see citing works

Faecalibacterium prausnitzii and human intestinal health

Miquel, S., Martín, R., Rossi, O., Bermúdez‐Humarán, L. G., Chatel, J., Sokol, H., Thomas, M., Wells, J. M., & Langella, P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.003 · Cited by 1,239 · see citing works

A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased <i>Akkermansia</i> spp. population in the gut microbiota of mice

Anhê, F. F., Roy, D., Pilon, G., Dudonné, S., Matamoros, S., Varin, T. V., Garofalo, C., Moine, Q., Desjardins, Y., Levy, E., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307142 · Cited by 1,137 · see citing works

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

Parhiz, H., Roohbakhsh, A., Soltani, F., Rezaee, R., & Iranshahi, M. (2014) · Phytotherapy Research · doi:10.1002/ptr.5256 · Cited by 916 · see citing works

Towards a more comprehensive concept for prebiotics

Bindels, L. B., Delzenne, N. M., Cani, P. D., & Walter, J. (2015) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2015.47 · Cited by 914 · see citing works

Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties

Marín, L., Miguélez, E. M., Villar, C. J., & Lombó, F. (2015) · BioMed Research International · doi:10.1155/2015/905215 · Cited by 778 · see citing works

Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity

Barbieri, R., Coppo, E., Marchese, A. E., Daglia, M., Sobarzo‐Sánchez, E., Nabavi, S. F., & Nabavi, S. M. (2016) · Microbiological Research · doi:10.1016/j.micres.2016.12.003 · Cited by 686 · see citing works

Dietary Polyphenols Promote Growth of the Gut Bacterium <i>Akkermansia muciniphila</i> and Attenuate High-Fat Diet–Induced Metabolic Syndrome

Roopchand, D. E., Carmody, R. N., Kuhn, P., Moskal, K., Rojas-Silva, P., Turnbaugh, P. J., & Raskin, I. (2015) · Diabetes · doi:10.2337/db14-1916 · Cited by 678 · see citing works

Biological significance of urolithins, the gut microbial ellagic Acid-derived metabolites: the evidence so far

Espín, J. C., Larrosa, M., García-Conesa, M. T., & Tomás-Barberán, F. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/270418 · Cited by 576 · see citing works

Pomegranate Juice, Total Pomegranate Ellagitannins, and Punicalagin Suppress Inflammatory Cell Signaling in Colon Cancer Cells

Adams, L. S., Seeram, N. P., Aggarwal, B. B., Takada, Y., Sand, D., & Heber, D. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf052005r · Cited by 530 · see citing works

Bacterial species involved in the conversion of dietary flavonoids in the human gut

Braune, A., & Blaut, M. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1158395 · Cited by 514 · see citing works

Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism

Larrosa, M., González‐Sarrías, A., Yáñez-Gascón, M. J., Selma, M. V., Azorín‐Ortuño, M., Toti, S., Tomás-Barberán, F. A., Dolara, P., & Espı́n, J. C. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.04.012 · Cited by 505 · see citing works

Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins

Turnbaugh, P. J., Quince, C., Faith, J. J., McHardy, A. C., Yatsunenko, T., Niazi, F., Affourtit, J., Egholm, M., Henrissat, B., Knight, R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002355107 · Cited by 478 · see citing works

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

Tomás‐Barberán, F. A., González‐Sarrías, A., García‐Villalba, R., Núñez‐Sánchez, M. A., Selma, M. V., García‐Conesa, M. T., & Espín, J. C. (2017) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.201500901 · Cited by 465 · see citing works

Gut microbiota: A player in aging and a target for anti-aging intervention

Vaiserman, A. M., Koliada, A. K., & Marotta, F. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.01.001 · Cited by 465 · see citing works

Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence

Tomé‐Carneiro, J., Larrosa, M., González‐Sarrías, A., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990407 · Cited by 451 · see citing works

Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats

Etxeberria, U., Arias, N., Boqué, N., Macarulla, M. T., Portillo, M. P., Martínez, J. A., & Milagro, F. I. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.01.002 · Cited by 446 · see citing works

Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health Status

Tomás-Barberán, F. A., García-Villalba, R., González-Sarrías, A., Selma, M. V., & Espín, J. C. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5024615 · Cited by 419 · see citing works

A survey of modulation of gut microbiota by dietary polyphenols

Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., Moreno-Arribas, M. V., & Bartolomé, B. (2015) · BioMed Research International · doi:10.1155/2015/850902 · Cited by 396 · see citing works

Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases

Roohbakhsh, A., Parhiz, H., Soltani, F., Rezaee, R., & Iranshahi, M. (2015) · Life Sciences · doi:10.1016/j.lfs.2014.12.030 · Cited by 395 · see citing works

Ellagitannins, ellagic acid and vascular health

Larrosa, M., García‐Conesa, M., Espı́n, J. C., & Tomás-Barberán, F. A. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.005 · Cited by 378 · see citing works

Red wine polyphenols modulate fecal microbiota and reduce markers of the metabolic syndrome in obese patients

Moreno‐Indias, I., Sánchez‐Alcoholado, L., Pérez‐Martínez, P., Andrés‐Lacueva, C., Cardona, F., Tinahones, F. J., & Queipo‐Ortuño, M. I. (2015) · Food & Function · doi:10.1039/c5fo00886g · Cited by 374 · see citing works

Interactions of gut microbiota with dietary polyphenols and consequences to human health

Tomás-Barberán, F. A., Selma, M. V., & Espı́n, J. C. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000314 · Cited by 359 · see citing works

Gastrointestinal microflora, food components and colon cancer prevention

Davis, C. D., & Milner, J. A. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.06.001 · Cited by 335 · see citing works

Antibiofilm Activity of Plant Polyphenols

Slobodníková, L., Fialová, S. B., Rendeková, K., et al. (2016) · Molecules · doi:10.3390/molecules21121717 · Cited by 326 · see citing works

Health Effects with Consumption of the Flax Lignan Secoisolariciresinol Diglucoside

Adolphe, J. L., Whiting, S. J., Juurlink, B. H. J., Thorpe, L. U., & Alcorn, J. (2010) · British Journal of Nutrition · doi:10.1017/s0007114509992753 · Cited by 314 · see citing works

Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species

Selma, M. V., Beltrán, D., García-Villalba, R., Espín, J. C., & Tomás-Barberán, F. A. (2014) · Food Funct. · doi:10.1039/c4fo00092g · Cited by 304 · see citing works

Isoflavones: Anti-Inflammatory Benefit and Possible Caveats

Yu, J., Bi, X., Yu, B., & Chen, D. (2016) · Nutrients · doi:10.3390/nu8060361 · Cited by 294 · see citing works

Soy isoflavones and prostate cancer: A review of molecular mechanisms

Mahmoud, A. M., Yang, W., & Bosland, M. C. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.12.010 · Cited by 283 · see citing works

Anthocyanins and Flavanones Are More Bioavailable than Previously Perceived: A Review of Recent Evidence

Kay, C. D., Pereira‐Caro, G., Ludwig, I. A., et al. (2017) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030216-025636 · Cited by 282 · see citing works

Bioactivity of genistein: A review of in vitro and in vivo studies

Ganai, A. A., & Farooqi, H. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.10.026 · Cited by 274 · see citing works

Mind the gap—deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites—a position paper focusing on carotenoids and polyphenols

Bohn, T., McDougall, G. J., Alegrı́a, A., Alminger, M., Arrigoni, E., Aura, A., Brito, C., Cilla, A., El, S. N., Karakaya, S., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400745 · Cited by 266 · see citing works

Pomegranate Fruit as a Rich Source of Biologically Active Compounds

Sreekumar, S., Sithul, H., Muraleedharan, P., Azeez, J. M., & Sreeharshan, S. (2014) · BioMed Research International · doi:10.1155/2014/686921 · Cited by 258 · see citing works

Preclinical Evidence for the Pharmacological Actions of Naringin: A Review

Bharti, S., Rani, N., Krishnamurthy, B., & Arya, D. S. (2014) · Planta Medica · doi:10.1055/s-0034-1368351 · Cited by 246 · see citing works

Polyphenols: Well Beyond The Antioxidant Capacity: Gallic Acid and Related Compounds as Neuroprotective Agents: You are What You Eat!

Daglia, M., Lorenzo, A. D., Nabavi, S. F., Talas, Z., & Nabavi, S. F. (2014) · Current Pharmaceutical Biotechnology · doi:10.2174/138920101504140825120737 · Cited by 244 · see citing works

Pomegranate and type 2 diabetes

Banihani, S. A., Swedan, S. F., & Alguraan, Z. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.03.003 · Cited by 237 · see citing works

Addressing the inter‐individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction

Manach, C., Milenković, D., de Wiele, T. V., Rodriguez‐Mateos, A., de Roos, B., García‐Conesa, M., Landberg, R., Gibney, E. R., Heinonen, M., Tomás-Barberán, F. A., et al. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600557 · Cited by 236 · see citing works

Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight‐obese individuals consuming pomegranate: A randomized clinical trial

González‐Sarrías, A., Garcı́a-Villalba, R., Romo‐Vaquero, M., Alasalvar, C., Örem, A., Zafrilla, P., Tomás-Barberán, F. A., Selma, M. V., & Espı́n, J. C. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600830 · Cited by 231 · see citing works

Phlebotonics for venous insufficiency

Martínez‐Zapata, M. J., Vernooij, R. W. M., Uriona, S., Stein, A. T., Moreno, R., Vargas, E., Capellà, D., & Bonfill, X. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003229.pub3 · Cited by 227 · see citing works

Pomegranate’s neuroprotective effects against Alzheimer’s disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites

Yuan, T., Ma, H., Liu, W., Niesen, D. B., Shah, N., Crews, R., Rose, K. N., Vattem, D. A., & Seeram, N. P. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00260 · Cited by 219 · see citing works

Mediterranean diet, dietary polyphenols and low grade inflammation: results from the MOLI‐SANI study

Bonaccio, M., Pounis, G., Cerletti, C., Donati, M. B., Iacoviello, L., de Gaetano, G., & on behalf of the MOLI‐SANI Study Investigators (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12924 · Cited by 216 · see citing works

Phylogeny of human intestinal bacteria that activate the dietary lignan secoisolariciresinol diglucoside

Clavel, T., Henderson, G., Engst, W., Dore, J. M., & Blaut, M. (2006) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2005.00057.x · Cited by 209 · see citing works

NF-κB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts

González‐Sarrías, A., Larrosa, M., Tomás-Barberán, F. A., Dolara, P., & Espı́n, J. C. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510000826 · Cited by 207 · see citing works

Bioactivation of Phytoestrogens: Intestinal Bacteria and Health

Landete, J. M., Arqués, J. L., Médina, M., Gaya, P., Rivas, B. D. L., & Múñoz, R. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.789823 · Cited by 204 · see citing works

In vitro transformation of chlorogenic acid by human gut microbiota

Tomás-Barberán, F. A., Garcı́a-Villalba, R., Quartieri, A., Raimondi, S., Amaretti, A., Leonardi, A., & Rossi, M. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300441 · Cited by 202 · see citing works

Gut metabotypes govern health effects of dietary polyphenols

Bolca, S., de Wiele, T. V., & Possemiers, S. (2012) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2012.09.009 · Cited by 201 · see citing works

Non-extractable polyphenols produce gut microbiota metabolites that persist in circulation and show anti-inflammatory and free radical-scavenging effects

González‐Sarrías, A., Espı́n, J. C., & Tomás-Barberán, F. A. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.07.010 · Cited by 190 · see citing works

Identifying the limits for ellagic acid bioavailability: A crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts

González‐Sarrías, A., Garcı́a-Villalba, R., Núñez‐Sánchez, M. Á., Tomé‐Carneiro, J., Zafrilla, P., Mulero, J., Tomás-Barberán, F. A., & Espı́n, J. C. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.09.019 · Cited by 184 · see citing works

Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota

Neyrinck, A. M., Etxeberría, U., Taminiau, B., Daube, G., Hul, M. V., Everard, A., Cani, P. D., Bindels, L. B., & Delzenne, N. M. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500899 · Cited by 181 · see citing works

Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts

Anhê, F. F., Varin, T. V., Barz, M. L., Desjardins, Y., Levy, E. H., Roy, D., & Marette, A. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0172-9 · Cited by 178 · see citing works

In Vitro Fermentation of a Red Wine Extract by Human Gut Microbiota: Changes in Microbial Groups and Formation of Phenolic Metabolites

Sánchez‐Patán, F., Cueva, C., Monagas, M., Walton, G., M., G. R. G., Quintanilla-López, J. E., Lebrón‐Aguilar, R., Martín-Álvarez, P. J., Moreno-Arribas, M. V., & Bartolomé, B. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2040115 · Cited by 177 · see citing works

Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus—systematic review and meta‐analysis

Hausenblas, H. A., Schoulda, J. A., & Smoliga, J. M. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400173 · Cited by 175 · see citing works

Nonextractable polyphenols, usually ignored, are the major part of dietary polyphenols: A study on the Spanish diet

Arranz, S., Silván, J. M., & Saura-Calixto, F. D. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900580 · Cited by 175 · see citing works

Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors — Results from a systematic review and meta-analysis of randomized controlled trials

Sahebkar, A., Șerban, M.-C., Ursoniu, S., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.04.008 · Cited by 175 · see citing works

Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells

González-Sarrías, A., Núñez-Sánchez, M. A., Tomás-Barberán, F. A., & Espín, J. C. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04538 · Cited by 174 · see citing works

The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome

Selma, M. V., González‐Sarrías, A., Salas‐Salvadó, J., Andrés‐Lacueva, C., Alasalvar, C., Örem, A., Tomás-Barberán, F. A., & Espı́n, J. C. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.03.012 · Cited by 168 · see citing works

A Systematic Review of the Efficacy of Bioactive Compounds in Cardiovascular Disease: Phenolic Compounds

Rangel-Huerta, Ó. D., Pastor‐Villaescusa, B., Aguilera, C. M., & Gil, Á. (2015) · Nutrients · doi:10.3390/nu7075177 · Cited by 167 · see citing works

Gut microbiota composition correlates with changes in body fat content due to weight loss

Remely, M., Tesar, I., Hippe, B., Gnauer, S., Rust, P., & Haslberger, A. G. (2015) · Beneficial Microbes · doi:10.3920/bm2014.0104 · Cited by 162 · see citing works

Red pitaya betacyanins protects from diet‐induced obesity, liver steatosis and insulin resistance in association with modulation of gut microbiota in mice

Song, H., Chu, Q., Yan, F., Yang, Y., Han, W., & Zheng, X. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13278 · Cited by 156 · see citing works

Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers

Li, Z., Henning, S. M., Lee, R., Lu, Q., Summanen, P. H., Thames, G., Corbett, K. M., Downes, J., Tseng, C., Finegold, S. M., et al. (2015) · Food & Function · doi:10.1039/c5fo00669d · Cited by 153 · see citing works

Inhibition of Quorum Sensing (QS) in Yersinia enterocolitica by an Orange Extract Rich in Glycosylated Flavanones

Truchado, P., Giménez‐Bastida, J. A., Larrosa, M., Castro-Ibáñez, I., Espı́n, J. C., Tomás-Barberán, F. A., García‐Conesa, M., & Allende, A. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301365a · Cited by 153 · see citing works

Genistein as antioxidant and antibrowning agents in in vivo and in vitro: A review

Mazumder, M. A. R., & Hongsprabhas, P. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.05.023 · Cited by 152 · see citing works

Potential protective properties of flax lignan secoisolariciresinol diglucoside

Imran, M., Ahmad, N., Anjum, F. M., et al. (2015) · Nutrition Journal · doi:10.1186/s12937-015-0059-3 · Cited by 151 · see citing works

A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels

Sahebkar, A. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.09.012 · Cited by 149 · see citing works

Caffeic acid ameliorates colitis in association with increasedAkkermansiapopulation in the gut microbiota of mice

Zhang, Z., Wu, X., Cao, S., Wang, L., Wang, D., Yang, H., Feng, Y., Wang, S., & Li, L. (2016) · Oncotarget · doi:10.18632/oncotarget.9306 · Cited by 149 · see citing works

Clostridium saccharogumia sp. nov. and Lactonifactor longoviformis gen. nov., sp. nov., two novel human faecal bacteria involved in the conversion of the dietary phytoestrogen secoisolariciresinol diglucoside

Clavel, T., Lippman, R., Gavini, F., Dore, J. M., & Blaut, M. (2006) · Systematic and Applied Microbiology · doi:10.1016/j.syapm.2006.02.003 · Cited by 145 · see citing works

Metabolic Fate of Ellagitannins: Implications for Health, and Research Perspectives for Innovative Functional Foods

Garcia-Muñoz, C., & Vaillant, F. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.644643 · Cited by 133 · see citing works

Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells

González‐Sarrías, A., Giménez‐Bastida, J. A., Núñez‐Sánchez, M. Á., Larrosa, M., García‐Conesa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0589-4 · Cited by 132 · see citing works

Healthy Subjects Differentially Respond to Dietary Capsaicin Correlating with Specific Gut Enterotypes

Kang, C., Zhang, Y., Zhu, X., Liu, K., Wang, X., Chen, M., Wang, J., Chen, H., Hui, S., Huang, L., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2786 · Cited by 132 · see citing works

Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial

Hazim, S., Curtis, P. J., Schär, M. Y., Ostertag, L. M., Kay, C. D., Minihane, A. M., & Cassidy, A. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.125690 · Cited by 130 · see citing works

Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials

Sahebkar, A., Ferri, C., Giorgini, P., Bo, S., Nachtigal, P., & Grassi, D. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.018 · Cited by 130 · see citing works

Interactions of Phytoestrogens with Estrogen Receptors .ALPHA. and .BETA. (III). Estrogenic Activities of Soy Isoflavone Aglycones and Their Metabolites Isolated from Human Urine

Kinjo, J., Tsuchihashi, R., Morito, K., Hirose, T., Aomori, T., Nagao, T., Okabe, H., Nohara, T., & Masamune, Y. (2004) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.27.185 · Cited by 129 · see citing works

Among Plant Lignans, Pinoresinol Has the Strongest Antiinflammatory Properties in Human Intestinal Caco-2 Cells3

During, A., Debouche, C., Raas, T., & Larondelle, Y. (2012) · Journal of Nutrition · doi:10.3945/jn.112.162453 · Cited by 128 · see citing works

Hesperidin metabolite hesperetin-7-O-glucuronide, but not hesperetin-3′-O-glucuronide, exerts hypotensive, vasodilatory, and anti-inflammatory activities

Yamamoto, M., Jokura, H., Hashizume, K., Ominami, H., Shibuya, Y., Suzuki, A., Hase, T., & Shimotoyodome, A. (2013) · Food & Function · doi:10.1039/c3fo60030k · Cited by 127 · see citing works

The effects of polyphenols on oxidative stress and the arachidonic acid cascade. Implications for the prevention/treatment of high prevalence diseases

Mitjavila, M. T., & Moreno, J. J. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.07.017 · Cited by 126 · see citing works

Gut metabolites and bacterial community networks during a pilot intervention study with flaxseeds in healthy adult men

Lagkouvardos, I., Kläring, K., Heinzmann, S. S., Platz, S., Scholz, B., Engel, K., Schmitt‐Kopplin, P., Haller, D., Rohn, S., Skurk, T., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500125 · Cited by 122 · see citing works

Microbial production of ellagic acid and biodegradation of ellagitannins

Aguilera-Carbo, A., Augur, C., Prado-Barragan, L. A., Favela-Torres, E., & Aguilar, C. N. (2008) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-1276-2 · Cited by 121 · see citing works

Phenols, lignans and antioxidant properties of legume and sweet chestnut flours

Durazzo, A., Turfani, V., Azzini, E., Maiani, G., & Carcea, M. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.09.062 · Cited by 109 · see citing works

Dietary phenolics against colorectal cancer—From promising preclinical results to poor translation into clinical trials: Pitfalls and future needs

Núñez‐Sánchez, M. Á., González‐Sarrías, A., Romo‐Vaquero, M., Garcı́a-Villalba, R., Selma, M. V., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400866 · Cited by 106 · see citing works

Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial

Núñez‐Sánchez, M. Á., González‐Sarrías, A., Garcı́a-Villalba, R., Monedero‐Saiz, T., Espin, N. V. G.-T., Gómez‐Sánchez, M. B., Sánchez‐Álvarez, C., García‐Albert, A. M., Rodríguez‐Gil, F. J., Ruiz‐Marín, M., et al. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.01.014 · Cited by 103 · see citing works

Gut Microbiota Metabolites of Dietary Lignans and Risk of Type 2 Diabetes: A Prospective Investigation in Two Cohorts of U.S. Women

Sun, Q., Wedick, N. M., Pan, A., Townsend, M. K., Cassidy, A., Franke, A. A., Rimm, E. B., Hu, F. B., & van Dam, R. M. (2014) · Diabetes Care · doi:10.2337/dc13-2513 · Cited by 102 · see citing works

The antioxidant activity of daidzein metabolites, O-desmethylangolensin and equol, in HepG2 cells

Choi, E. J., & Kim, G. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1752 · Cited by 100 · see citing works

O-Desmethylangolensin: The Importance of Equol's Lesser Known Cousin to Human Health

Frankenfeld, C. L. (2011) · Advances in Nutrition · doi:10.3945/an.111.000539 · Cited by 95 · see citing works

Dietary total flavonoids intake and risk of mortality from all causes and cardiovascular disease in the general population: A systematic review and meta‐analysis of cohort studies

Liu, X., Liu, Y., Huang, Y. H., Yu, H., Yuan, S., Tang, B., Wang, P., & He, Q. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201601003 · Cited by 89 · see citing works

Pomegranate ellagitannins stimulate the growth of Akkermansia muciniphila in vivo

Henning, S. M., Summanen, P. H., Lee, R., Yang, J., Finegold, S. M., Heber, D., & Li, Z. (2016) · Anaerobe · doi:10.1016/j.anaerobe.2016.12.003 · Cited by 85 · see citing works

Lingonberries alter the gut microbiota and prevent low-grade inflammation in high-fat diet fed mice

Heyman‐Lindén, L., Kotowska, D., Sand, E., Bjursell, M., Plaza, M., Turner, C., Holm, C., Fåk, F., & Berger, K. (2016) · Food & Nutrition Research · doi:10.3402/fnr.v60.29993 · Cited by 83 · see citing works

Association between consumption of soy and risk of cardiovascular disease: A meta-analysis of observational studies

Yan, Z., Zhang, X., Li, C., Jiao, S., & Dong, W. (2017) · European Journal of Preventive Cardiology · doi:10.1177/2047487316686441 · Cited by 82 · see citing works

Flavanone metabolites decrease monocyte adhesion to TNF-α-activated endothelial cells by modulating expression of atherosclerosis-related genes

Chanet, A., Milenković, D., Claude, S., Maier, J. A. M., Khan, M. K., Rakotomanomana, N., Shinkaruk, S., Bérard, A. M., Bennetau‐Pelissero, C., Mazur, A., et al. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114512005454 · Cited by 80 · see citing works

Anti-inflammatory effects of pomegranate (Punica granatum L.) husk ellagitannins in Caco-2 cells, an in vitro model of human intestine

Hollebeeck, S., Winand, J., Hérent, M., During, A., Quetin‐Leclercq, J., Larondelle, Y., & Schneider, Y. (2012) · Food & Function · doi:10.1039/c2fo10258g · Cited by 80 · see citing works

Orange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease

Schär, M. Y., Curtis, P. J., Hazim, S., Ostertag, L. M., Kay, C. D., Potter, J. F., & Cassidy, A. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.104364 · Cited by 79 · see citing works

Role of bifidobacteria in the hydrolysis of chlorogenic acid

Raimondi, S., Anighoro, A., Quartieri, A., Amaretti, A., Tomás-Barberán, F. A., Rastelli, G., & Rossi, M. (2014) · MicrobiologyOpen · doi:10.1002/mbo3.219 · Cited by 78 · see citing works

Cardiometabolic risk and gut microbial phytoestrogen metabolite phenotypes

Frankenfeld, C. L. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500900 · Cited by 76 · see citing works

An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer

Koosha, S., Alshawsh, M. A., Looi, C. Y., Seyedan, A., & Mohamed, Z. (2016) · International Journal of Medical Sciences · doi:10.7150/ijms.14485 · Cited by 75 · see citing works

MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: Critical issues to discern between modulatory effects and potential artefacts

Núñez‐Sánchez, M. Á., Dávalos, A., González‐Sarrías, A., Casas‐Agustench, P., Visioli, F., Monedero‐Saiz, T., Espin, N. V. G.-T., Gómez‐Sánchez, M. B., Sánchez‐Álvarez, C., García‐Albert, A. M., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500357 · Cited by 71 · see citing works

Bioconversion of (−)-Epicatechin, (+)-Epicatechin, (−)-Catechin, and (+)-Catechin by (−)-Epigallocatechin-Metabolizing Bacteria

Takagaki, A., & Nanjo, F. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b14-00813 · Cited by 70 · see citing works

Clinical phenotype clustering in cardiovascular risk patients for the identification of responsive metabotypes after red wine polyphenol intake

Vázquez‐Fresno, R., Llorach, R., Perera-Lluna, A., Mandal, R., Feliz, M., Tinahones, F. J., Wishart, D. S., & Andrés‐Lacueva, C. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.10.002 · Cited by 69 · see citing works

Dietary flaxseed modulates the colonic microenvironment in healthy C57Bl/6 male mice which may alter susceptibility to gut-associated diseases

Power, K. A., Lepp, D., Zarepoor, L., Monk, J. M., Wu, W., Tsao, R., & Liu, R. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.09.028 · Cited by 69 · see citing works

Detection of novel metabolites of flaxseed lignans in vitro and in vivo

Quartieri, A., Garcı́a-Villalba, R., Amaretti, A., Raimondi, S., Leonardi, A., Rossi, M., & Tomás-Barberán, F. A. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500773 · Cited by 64 · see citing works

Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice

Cho, S., Kim, J., Lee, J. H., Sim, J. H., Cho, D.-H., Bae, I., Lee, H., Seol, M. A., Shin, H. M., Kim, T.-J., et al. (2016) · Scientific Reports · doi:10.1038/srep39026 · Cited by 63 · see citing works

Hesperetin and its sulfate and glucuronide metabolites inhibit TNF-α induced human aortic endothelial cell migration and decrease plasminogen activator inhibitor-1 (PAI-1) levels

Giménez‐Bastida, J. A., González‐Sarrías, A., Vallejo, F., et al. (2015) · Food & Function · doi:10.1039/c5fo00771b · Cited by 62 · see citing works

Effects of Cocoa Husk Feeding on the Composition of Swine Intestinal Microbiota

Magistrelli, D., Zanchi, R., Malagutti, L., Galassi, G., Canzi, E., & Rosi, F. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b05732 · Cited by 62 · see citing works

Lipid profile changes after pomegranate consumption: A systematic review and meta-analysis of randomized controlled trials

Sahebkar, A., Simental‐Mendía, L. E., Giorgini, P., Ferri, C., & Grassi, D. (2016) · Phytomedicine · doi:10.1016/j.phymed.2015.12.014 · Cited by 59 · see citing works

Microbiome sequencing: challenges and opportunities for molecular medicine

Clavel, T., Lagkouvardos, I., & Hiergeist, A. (2016) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2016.1184574 · Cited by 42 · see citing works

Tiny molecule, big power: Multi-target approach for curcumin in diabetic cardiomyopathy

Karuppagounder, V., Arumugam, S., Giridharan, V. V., et al. (2016) · Nutrition · doi:10.1016/j.nut.2016.09.005 · Cited by 42 · see citing works

Effects of supplementation with pomegranate juice on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials

Sahebkar, A., Gurban, C., Serban, A., Andrica, F., & Șerban, M.-C. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.12.008 · Cited by 40 · see citing works

Effect of whole soy and purified daidzein on ambulatory blood pressure and endothelial function—a 6-month double-blind, randomized controlled trial among Chinese postmenopausal women with prehypertension

Zm, L., Ho, S. C., Chen, Y.-M., Tomlinson, B., To, K., To, K., & Woo, J. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.24 · Cited by 39 · see citing works

Effect of Black Tea Consumption on Blood Cholesterol: A Meta-Analysis of 15 Randomized Controlled Trials

Wang, D., Chen, C., Wang, Y., Liu, J., & Lin, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107711 · Cited by 35 · see citing works

Metabolic syndrome: Evidences for a personalized nutrition

Pérez‐Martínez, P., Garcia‐Rios, A., Delgado‐Lista, J., Pérez‐Jiménez, F., & López‐Miranda, J. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100531 · Cited by 33 · see citing works

Metabolomics reveals differences between three daidzein metabolizing phenotypes in adults with cardiometabolic risk factors

Reverri, E. J., Slupsky, C. M., Mishchuk, D. O., & Steinberg, F. M. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600132 · Cited by 33 · see citing works

Effects of naringenin and its phase II metabolites onin vitrohuman macrophage gene expression

Dall’Asta, M., Derlindati, E., Curella, V., Mena, P. R., Calani, L., Ray, S., Zavaroni, I., Brighenti, F., & Rio, D. D. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.804039 · Cited by 31 · see citing works

A Critical Evaluation of the Clinical Evidence for Pomegranate Preparations in the Prevention and Treatment of Cardiovascular Diseases

Vlachojannis, C., Erné, P., Schoenenberger, A. W., & Chrubasik‐Hausmann, S. (2015) · Phytotherapy Research · doi:10.1002/ptr.5280 · Cited by 27 · see citing works

Effect of Soy Isoflavone Supplementation on Endothelial Dysfunction and Oxidative Stress in Equol-Producing Postmenopausal Women

Pusparini, P., Yenny, Y., & Hidayat, A. (2015) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530314666141202123309 · Cited by 14 · see citing works

The Role of Polyphenols in Human Health and Food Systems: A Mini-Review

Cory, H., Passarelli, S., Szeto, J., Tamez, M., & Mattei, J. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00087 · Cited by 1,297 · see citing works

Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health

Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works

Alzheimer’s disease and gut microbiota modifications: The long way between preclinical studies and clinical evidence

Mancuso, C., & Santangelo, R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.009 · Cited by 232 · see citing works

The role of the gut microbiota in the metabolism of polyphenols as characterized by gnotobiotic mice

Pasinetti, G. M., Singh, R., Westfall, S., Herman, F., Faith, J., & Ho, L. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171151 · Cited by 112 · see citing works

Effects of probiotics on the content and bioaccessibility of phenolic compounds in red pitaya pulp

Morais, S. G. G., da Silva Campelo Borges, G., dos Santos Lima, M., Martín-Belloso, O., & Magnani, M. (2019) · Food Research International · doi:10.1016/j.foodres.2019.108681 · Cited by 109 · see citing works

Gut Microbiota: A Pivotal Hub for Polyphenols as Antidepressants

Zhou, N., Gu, X., Zhuang, T., Xu, Y., Yang, L., & Zhou, M. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01461 · Cited by 54 · see citing works

Dietary bioactive compounds as modulators of mitochondrial function

Vásquez-Reyes, S., Velázquez-Villegas, L. A., Vargas-Castillo, A., Noriega, L. G., Torres, N., & Tovar, A. R. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108768 · Cited by 35 · see citing works

Resilience by design: How nature, nurture, environment, and microbiome mitigate stress and allostatic load

Chbeir, S., & Carrión, V. (2023) · World Journal of Psychiatry · doi:10.5498/wjp.v13.i5.144 · Cited by 25 · see citing works

DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

Effect of retinol on iron bioavailability from Iranian bread in a Caco-2 cell culture model

Gargari, B. P., Razavieh, S.-V., Mahboob, S., et al. (2006) · Nutrition · doi:10.1016/j.nut.2006.02.005 · Cited by 20 · see citing works

Prediction of Bioavailability

Mandagere, A. K., & Jones, B. (2003) · Methods and principles in medicinal chemistry · doi:10.1002/3527601473.ch19 · Cited by 2 · see citing works

Study of the bioavailability of different formulations of 8‐methoxypsoralen in the dog

Monbaliu, J. G., Belpaire, F. M., & Bogaert, M. (1988) · Biopharmaceutics & Drug Disposition · doi:10.1002/bod.2510090102 · Cited by 4 · see citing works

Dissolution Systems for Chloramphenicol Tablet Bioavailability

Ogata, H., SHIBAZAKI, T., Inoue, T., et al. (1979) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600680615 · Cited by 15 · see citing works