The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Dietary Sources and Antioxidant Effects of Ergothioneine
Abstract
Ergothioneine is a native membrane-impermeable thiol compound that is specifically accumulated in cells via the organic cation transporter OCTN1. In humans, OCTN1 and ergothioneine have been implicated in the etiopathogenesis of autoimmune disorders. However, available evidence about dietary sources and the functional role of ergothioneine in human physiology is scarce. Here, we analyzed the ergothioneine content in common foods using liquid chromatography tandem-mass spectrometry. Additionally, we assessed the protective potency of ergothioneine against various oxidative stressors in OCTN1-expressing cells in comparison with the main intracellular thiol antioxidant glutathione by evaluating cell viability with the MTT reduction assay. Only some food contained ergothioneine with highest concentrations detected in specialty mushrooms, kidney, liver, black and red beans, and oat bran. Ergothioneine exhibited cell protection only against copper(II)-induced toxicity but was far less potent than glutathione, indicting that ergothioneine is not involved in the intracellular antioxidant thiol defense system.
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Cites
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Functional variants of OCTN cation transporter genes are associated with Crohn disease
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Discovery of the ergothioneine transporter
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Self-citationThe Role of Glutathione in Copper Metabolism and Toxicity
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Cited by
Ergothioneine; antioxidant potential, physiological function and role in disease
Cheah, I. K., & Halliwell, B. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.09.017 · Cited by 514
Fennema, D., Phillips, I. R., & Shephard, E. A. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.070615 · Cited by 355
The unusual amino acid L-ergothioneine is a physiologic cytoprotectant
Paul, B. D., & Snyder, S. H. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.163 · Cited by 304
The biology of ergothioneine, an antioxidant nutraceutical
Borodina, I., Kenny, L. C., McCarthy, C. M., Paramasivan, K., Pretorius, E., Roberts, T. J., van der Hoek, S. A., & Kell, D. B. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422419000301 · Cited by 296
“DM), while of those more common outside Asia, porcini or ceps (Boletus edulis, > 7 mg/g DM), stand out(6,294,300).”
BackgroundCheah, I. K., Tang, R. M. Y., Yew, T. S. Z., Lim, K. H. C., & Halliwell, B. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6778 · Cited by 196
Metadata
- Authors
- Ey, J., Schömig, E., & Taubert, D.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-07-06
- Volume
- 55
- Issue
- 16
- Pages
- 6466-6474
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2058888887
- Cited by
- 313
- References
- 35
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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