A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms
Abstract
A range of sulfur-containing natural products from plants, fungi, bacteria and animals have recently been investigated to determine their therapeutic potential. Preliminary in vitro and in vivo studies of compounds such as ergothioneine, ovothiols, allicin, leinamycin, varacin, lenthionine and diallyltetrasulfide have provided evidence for antioxidant, antibacterial, antimicrobial, antifungal and anticancer properties. The biological activity of these compounds is the result of specific chemical properties which converge in chemotypes such as thiols, disulfides, sulfenic and sulfinic acids,thiosulfinates, sulfoxides, sulfones and polysulfides. Redox-activity, catalysis, metal binding, enzyme inhibition and radical generation allow reactive sulfur species to interact with oxidative stressors, to affect the function of redox-sensitive cysteine proteins and to disrupt the integrity of DNA and cellular membranes. In some cases, the biological activity of sulfur-containing plant products depends on initial enzymatic activation, which allows thiosulfinates and isothiocyanates to be generated with high target selectivity. Not surprisingly, research into the biochemical and pharmacological properties of the lesser known sulfur chemotypes is rapidly gathering momentum.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ERG has an unusually high midpoint potential for a thiol, being +0·06 V.
“Its midpoint potential for a thiol is consequently unusually high, being +0·06 V v. −0·2 to −0·4 V for typical thiols including glutathione(4,39–41) and mycothiol(42,43), and −0·193 V for the also somewhat oxidising thiol cofactor coenzyme M, which is 2-mercaptoethanesulfonate(44).”
From The biology of ergothioneine, an antioxidant nutraceutical (2020) · cites this paper as [39]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587 · see citing works
The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
Fahey, J. W., Zalcmann, A. T., & Talalay, P. (2001) · Phytochemistry · doi:10.1016/s0031-9422(00)00316-2 · Cited by 2,968 · see citing works
BIOLOGY AND BIOCHEMISTRY OF GLUCOSINOLATES
Halkier, B. A., & Gershenzon, J. (2006) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105228 · Cited by 2,279 · see citing works
Antimicrobial properties of allicin from garlic
Ankri, S., & Mirelman, D. (1999) · Microbes and Infection · doi:10.1016/s1286-4579(99)80003-3 · Cited by 1,185 · see citing works
The Organosulfur Chemistry of the Genus Allium – Implications for the Organic Chemistry of Sulfur
Block, E. (1992) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199211351 · Cited by 997 · see citing works
ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin
Biteau, B., Labarre, J., & Tolédano, M. B. (2003) · Nature · doi:10.1038/nature02075 · Cited by 970 · see citing works
Sulfur and Selenium: The Role of Oxidation State in Protein Structure and Function
Jacob, C., Giles, G. I., Giles, N. M., & Sies, H. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200300573 · Cited by 757 · see citing works
Self-citationSynthetic organoselenium compounds as antioxidants: glutathione peroxidase activity
Mugesh, G., & Singh, H. B. (2000) · Chemical Society Reviews · doi:10.1039/a908114c · Cited by 666 · see citing works
Nuclear Factor κB Is a Molecular Target for Sulforaphane-mediated Anti-inflammatory Mechanisms
Heiß, E. H., Herhaus, C., Klimo, K., Bartsch, H., & Gerhäuser, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104794200 · Cited by 633 · see citing works
Redox modifications of protein-thiols: emerging roles in cell signaling.
Biswas, S., Chida, A., & Rahman, I. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.10.044 · Cited by 631 · see citing works
Discovery of the ergothioneine transporter
Gründemann, D., Harlfinger, S., Gölz, S., Geerts, A., Lazar, A., Berkels, R., Jung, N., RUBBERT, A., & Schömig, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408624102 · Cited by 613 · see citing works
Thiolate ligands in metallothionein confer redox activity on zinc clusters
Maret, W., & Vallée, B. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3478 · Cited by 576 · see citing works
Metal and Redox Modulation of Cysteine Protein Function
Giles, N. M., Watts, A. B., Giles, G. I., Fry, F. H., Littlechild, J. A., & Jacob, C. (2003) · Chemistry & Biology · doi:10.1016/s1074-5521(03)00174-1 · Cited by 487 · see citing works
Self-citationRhee, S. G., Yang, K.-S., Kang, S. W., Woo, H. A., & Chang, T.-S. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.619 · Cited by 376 · see citing works
Akerboom, T. P. M., Bilzer, M., & Sies, H. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34713-6 · Cited by 342 · see citing works
Activities of Garlic Oil, Garlic Powder, and Their Diallyl Constituents against Helicobacter pylori
O’Gara, E. A., Hill, D. J. T., & Maslin, D. J. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.5.2269-2273.2000 · Cited by 328 · see citing works
Reactive Sulfur Species: An Emerging Concept in Oxidative Stress
Giles, G. I., & Jacob, C. (2002) · Biological Chemistry · doi:10.1515/bc.2002.042 · Cited by 314 · see citing works
Self-citationHypothesis: the role of reactive sulfur species in oxidative stress
Giles, G. I., Tasker, K. M., & Jacob, C. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00710-9 · Cited by 291 · see citing works
Self-citationEbselen: prospective therapy for cerebral ischaemia
Parnham, M. J., & Sies, H. (2000) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.9.3.607 · Cited by 284 · see citing works
S‐Glutathionylation: from redox regulation of protein functions to human diseases
Giustarini, D., Rossi, R., Milzani, A., Colombo, R., & Dalle‐Donne, I. (2004) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2004.tb00275.x · Cited by 279 · see citing works
Chelators as Antidotes of Metal Toxicity: Therapeutic and Experimental Aspects
Blanuša, M., Varnai, V. M., Piasek, M., & Kostial, K. (2005) · Current Medicinal Chemistry · doi:10.2174/092986705774462987 · Cited by 272 · see citing works
Zinc and Sulfur: A Critical Biological Partnership
Maret, W. (2004) · Biochemistry · doi:10.1021/bi036340p · Cited by 270 · see citing works
The antioxidant action of ergothioneine
Akanmu, D., Cecchini, R., Aruoma, O. I., & Halliwell, B. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90158-f · Cited by 251 · see citing works
The Chemistry of Organic Polysulfanes R−Sn−R (n > 2)
Steudel, R. (2002) · Chemical Reviews · doi:10.1021/cr010127m · Cited by 233 · see citing works
Tsao, S., & Yin, M. (2001) · Journal of Medical Microbiology · doi:10.1099/0022-1317-50-7-646 · Cited by 219 · see citing works
Hydrogen sulphide — a novel mediator of inflammation?
Li, L., Bhatia, M. L., & Moore, P. A. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.10.007 · Cited by 219 · see citing works
Xiao, D., Herman-Antosiewicz, A., Antosiewicz, J., Xiao, H., Brisson, M., Lazo, J. S., & Singh, S. V. (2005) · Oncogene · doi:10.1038/sj.onc.1208759 · Cited by 199 · see citing works
[32] Ergothioneine as antioxidant
Hartman, P. E. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86124-e · Cited by 197 · see citing works
Ovothiol and trypanothione as antioxidants in trypanosomatids
Ariyanayagam, M. R. (2001) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(01)00285-7 · Cited by 192 · see citing works
Davidson, B. S., Molinski, T. F., Barrows, L. R., & Ireland, C. M. (1991) · Journal of the American Chemical Society · doi:10.1021/ja00012a065 · Cited by 192 · see citing works
N-Acetylcysteine In The Prevention Of Radiocontrast-Induced Nephropathy
Fishbane, S. N., Durham, J. H., Marzo, K. P., & Rudnick, M. R. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000107562.68920.92 · Cited by 188 · see citing works
Bertl, E., Bartsch, H., & Gerhäuser, C. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0324 · Cited by 169 · see citing works
Biological Chemistry of Naturally Occurring Thiols of Microbial and Marine Origin
Hand, C. E., & Honek, J. F. (2005) · Journal of Natural Products · doi:10.1021/np049685x · Cited by 158 · see citing works
Antosiewicz, J., Herman-Antosiewicz, A., Marynowski, S. W., & Singh, S. V. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0356 · Cited by 156 · see citing works
Isolation, Structure, and Synthesis of Lenthionine and Its Analogs.
Morita, K., & Kobayashi, S. (1967) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.15.988 · Cited by 149 · see citing works
The sulfinic acid switch in proteins
Jacob, C., Holme, A. L., & Fry, F. H. (2004) · Organic & Biomolecular Chemistry · doi:10.1039/b406180b · Cited by 141 · see citing works
Self-citationFive new alkaloids from the tropical ascidian, Lissoclinum sp. lissoclinotoxin A is chiral
Searle, P. A., & Molinski, T. F. (1994) · The Journal of Organic Chemistry · doi:10.1021/jo00101a018 · Cited by 136 · see citing works
KARA, M., Asano, K., Kawamoto, I., TAKIOUCHI, T., KATSUMATA, S., Takahashi, K., & Nakano, H. (1989) · The Journal of Antibiotics · doi:10.7164/antibiotics.42.1768 · Cited by 129 · see citing works
DC 107, a novel antitumor antibiotic produced by a Streptomyces sp.
Hara, M., TAKAHASHI, I., Yoshida, M., Asano, K., Kawamoto, I., Morimoto, M., & Nakano, H. (1989) · The Journal of Antibiotics · doi:10.7164/antibiotics.42.333 · Cited by 125 · see citing works
Davis, S. R. (2005) · Mycoses · doi:10.1111/j.1439-0507.2004.01076.x · Cited by 119 · see citing works
Oxidation of glutathione by hydrogen peroxide and other oxidizing agents
Finley, J. W., Wheeler, E. L., & Witt, S. C. (1981) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00104a045 · Cited by 114 · see citing works
Biologically active sulphur compounds from the green alga Chara globularis
Anthoni, U., Christophersen, C., Madsen, J. Ø., Wium‐Andersen, S., & Jacobsen, N. (1980) · Phytochemistry · doi:10.1016/0031-9422(80)83090-1 · Cited by 114 · see citing works
Tsao, S., & Yin, M. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/47.5.665 · Cited by 113 · see citing works
Barillari, J., Cervellati, R., Paolini, M., Tatibouët, A., Rollin, P., & Iori, R. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051465h · Cited by 113 · see citing works
Liu, K., Chen, H., Wang, R.-Y., Lei, Y., Sheen, L., & Lii, C. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060043k · Cited by 103 · see citing works
Cummings, J., Spanswick, V. J., Tomasz, M., & Smyth, J. F. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00073-2 · Cited by 97 · see citing works
Mitra, K., Kim, W., Daniels, J. S., & Gates, K. S. (1997) · Journal of the American Chemical Society · doi:10.1021/ja971359z · Cited by 96 · see citing works
Identification of sulfurous compounds of Shiitake mushroom (Lentinus edodes Sing.)
Chen, C. C., & Ho, C. T. (1986) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00071a016 · Cited by 90 · see citing works
Isolation and synthesis of lenthionine, an odorous substance of , an edible mushroom.
Morita, K., & Kobayashi, S. (1966) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)99667-4 · Cited by 87 · see citing works
Shadkchan, Y. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh174 · Cited by 80 · see citing works
Varacin and Three New Marine Antimicrobial Polysulfides from the Far-Eastern Ascidian Polycitorsp.
Makarieva, T. N., Stonik, V. A., Dmitrenok, A. S., Grebnev, B. B., Isakov, V. V., Rebachyk, N. M., & Rashkes, Y. W. (1995) · Journal of Natural Products · doi:10.1021/np50116a015 · Cited by 80 · see citing works
Mechanisms of DNA Damage by Leinamycin
Gates, K. S. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000089m · Cited by 77 · see citing works
Generation of reactive oxygen species by a persulfide (BnSSH)
Chatterji, T., Keerthi, K., & Gates, K. S. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.05.110 · Cited by 77 · see citing works
Miron, T., Mironchik, M., Mirelman, D., Wilchek, M., & Rabinkov, A. (2003) · PubMed · Cited by 76 · see citing works
Arditti, F. D., Rabinkov, A., Miron, T., Reisner, Y., Berrébi, A., Wilchek, M., & Mirelman, D. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.325.4.2 · Cited by 76 · see citing works
Giles, G. I., Tasker, K. M., Collins, C. A., Giles, N. M., O'ROURKE, E., & Jacob, C. (2002) · Biochemical Journal · doi:10.1042/bj20011882 · Cited by 75 · see citing works
Self-citationHoller, T. P., & Hopkins, P. B. (1988) · Journal of the American Chemical Society · doi:10.1021/ja00222a057 · Cited by 66 · see citing works
Detection of ferryl myoglobin in the isolated ischemic rat heart
Arduini, A., Eddy, L. J., & Hochstein, P. E. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90130-b · Cited by 66 · see citing works
Turner, E. E., Klevit, R. E., Hopkins, P. B., & Shapiro, B. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69270-1 · Cited by 63 · see citing works
Cyclic polysulphides from Parkia speciosa
Gmelin, R., Susilo, R., & Fenwick, G. R. (1981) · Phytochemistry · doi:10.1016/0031-9422(81)83085-3 · Cited by 62 · see citing works
Bailly, F., Zoete, V., Vamecq, J., Catteau, J., & Bernier, J. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02234-1 · Cited by 57 · see citing works
A biologically active 1,2,3-trithiane derivative from the New Zealand ascidain Aplidium sp. D.
Copp, B. R., Blunt, J. W., Munro, M. H. G., & Pannell, L. K. (1989) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)80488-3 · Cited by 54 · see citing works
Use of a Substrate/Alliinase Combination To Generate Antifungal Activity in Situ
Fry, F. H., Okarter, N., Baynton-Smith, C., Kershaw, M. J., Talbot, N. J., & Jacob, C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048481j · Cited by 53 · see citing works
Self-citationEnzyme-catalized Evolution of Lenthionine from Lentinic Acid
YASUMOTO, K., Iwami, K., & Mitsuda, H. (1971) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1971.10860188 · Cited by 51 · see citing works
The Sulfur Chemistry of Shiitake Mushroom
Sneeden, E. Y., Harris, H. H., Pickering, I. J., Prince, R. C., Johnson, S., Li, X., Block, E., & George, G. N. (2003) · Journal of the American Chemical Society · doi:10.1021/ja039239g · Cited by 47 · see citing works
Tucker, S. C., Ahl, M., Bush, A. I., Westaway, D. A., Huang, X., & Rogers, J. T. (2005) · Current Alzheimer Research · doi:10.2174/1567205053585855 · Cited by 44 · see citing works
Acid-Promoted DNA-Cleaving Activities and Total Synthesis of Varacin C
Lee, A. H. F., Chen, J., Liu, D., Leung, T. Y. C., Chan, A. S. C., & Li, T. (2002) · Journal of the American Chemical Society · doi:10.1021/ja020531i · Cited by 44 · see citing works
The Role of Amine in the Mechanism of Pentathiepin (Polysulfur) Antitumor Agents
Brzostowska, E. M., & Greer, A. (2002) · Journal of the American Chemical Society · doi:10.1021/ja027416s · Cited by 37 · see citing works
Turner, E. E., Somers, C. E., & Shapiro, B. M. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38852-x · Cited by 36 · see citing works
Kouokam, J. C., Jahns, T., & Becker, H. (2002) · Planta Medica · doi:10.1055/s-2002-36341 · Cited by 31 · see citing works
Ab initio studies of the properties of intracellular thiols ergothioneine and ovothiol
Hand, C. E., Taylor, N. J., & Honek, J. F. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.01.014 · Cited by 30 · see citing works
Wilson's Disease: Clinical, Genetic and Pharmacological Findings
Leggio, L., Addolorato, G., Abenavoli, L., & Gasbarrini, A. (2005) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200501800102 · Cited by 29 · see citing works
Zoete, V., Bailly, F., Vezin, H., Teissier, E., Duriez, P., Fruchart, J.-C., Catteau, J.-P., & Bernier, J.-L. (2000) · Free Radical Research · doi:10.1080/10715760000300521 · Cited by 27 · see citing works
Effects of allitridi on cell cycle arrest of human gastric cancer cells
Ha, M.-W. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i35.5433 · Cited by 26 · see citing works
Pearce, A. N., Babcock, R. C., Battershill, C. N., Lambert, G., & Copp, B. R. (2001) · The Journal of Organic Chemistry · doi:10.1021/jo010769+ · Cited by 24 · see citing works
Sulfur-containing compounds from Scorodocarpus borneensis and their antimicrobial activity
Lim, H., Kubota, K., Kobayashi, A., & Sugawara, F. (1998) · Phytochemistry · doi:10.1016/s0031-9422(97)00961-8 · Cited by 22 · see citing works
1,2,3-Trithiane-5-carboxylic acid, a first contact allergen from Asparagus officinalis (Liliaceae)
Hausen, B. M. (1996) · American Journal of Contact Dermatitis · doi:10.1016/s1046-199x(96)90032-9 · Cited by 20 · see citing works
Vamecq, J., Maurois, P., Bac, P., Bailly, F., Bernier, J., Stables, J. P., Husson, I., & Gressèns, P. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02846.x · Cited by 20 · see citing works
Cassipoureamide-A and -B: New Sulfur-Containing Amides from Stem Wood of Cassipourea guianensis
Ichimaru, M., Kato, A., & Hashimoto, Y. (2000) · Journal of Natural Products · doi:10.1021/np000195o · Cited by 18 · see citing works
Sulfur-Containing Alkaloids from Cassipourea guianensis
Kato, A., Okada, M., & Hashimoto, Y. (1985) · Journal of Natural Products · doi:10.1021/np50038a014 · Cited by 14 · see citing works
Kouokam, J. C., Zapp, J., & Becker, H. (2001) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2001-11-1217 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Free radicals, reactive oxygen species, oxidative stress and its classification
Lushchak, V. I. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.10.016 · Cited by 1,665 · see citing works
Enzymatic Carbon–Sulfur Bond Formation in Natural Product Biosynthesis
Dunbar, K. L., Scharf, D. H., Litomska, A., & Hertweck, C. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00697 · Cited by 619 · see citing works
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities
Wondrak, G. T. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2541 · Cited by 462 · see citing works
Rhee, S. G., Yang, K.-S., Kang, S. W., Woo, H. A., & Chang, T.-S. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.619 · Cited by 376 · see citing works
Dietary Sources and Antioxidant Effects of Ergothioneine
Ey, J., Schömig, E., & Taubert, D. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071328f · Cited by 314 · see citing works
The biology of ergothioneine, an antioxidant nutraceutical
Borodina, I., Kenny, L. C., McCarthy, C. M., Paramasivan, K., Pretorius, E., Roberts, T. J., van der Hoek, S. A., & Kell, D. B. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422419000301 · Cited by 296 · see citing works
“…midpoint potential for a thiol is consequently unusually high, being þ 0 · 06 V v. − 0 · 2 to − 0 · 4 V for typical thiols including glutathione (4,39 – 41) and mycothiol (42,43) , and − 0 · 193 V for the also somewhat oxidising thiol cofactor coenzyme M, which is 2-mercaptoethanesulfonate (44) .”
BackgroundTransition Metal Photoredox Catalysis of Radical Thiol-Ene Reactions
Tyson, E. L., Ament, M. S., & Yoon, T. P. (2012) · The Journal of Organic Chemistry · doi:10.1021/jo3020825 · Cited by 276 · see citing works
Wang, Y., Liu, D., Zheng, Q., Zhao, Q., Zhang, H., Ma, Y., Fallon, J. K., Fu, Q., Haynes, M. T., Lin, G., et al. (2014) · Nano Letters · doi:10.1021/nl502044x · Cited by 253 · see citing works
Selective Late‐Stage Oxygenation of Sulfides with Ground‐State Oxygen by Uranyl Photocatalysis
Li, Y., Rizvi, S. A., Hu, D., Sun, D., Gao, A., Zhou, Y., Li, J. X., & Jiang, X. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201906080 · Cited by 246 · see citing works
Heteroatom–Heteroatom Bond Formation in Natural Product Biosynthesis
Waldman, A. J., Ng, T. L., Wang, P., & Balskus, E. P. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00621 · Cited by 225 · see citing works
Polysulfides as biologically active ingredients of garlic
Münchberg, U., Anwar, A., Mecklenburg, S., & Jacob, C. (2007) · Organic & Biomolecular Chemistry · doi:10.1039/b703832a · Cited by 219 · see citing works
Self-citationThe reaction of H2S with oxidized thiols: generation of persulfides and implications to H2S biology
Francoleon, N. E., Carrington, S. J., & Fukuto, J. M. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.09.015 · Cited by 199 · see citing works
Antioxidant Anti-Inflammatory Treatment in Type 2 Diabetes
Ceriello, A., & Testa, R. (2009) · Diabetes Care · doi:10.2337/dc09-s316 · Cited by 199 · see citing works
Cheah, I. K., Tang, R. M. Y., Yew, T. S. Z., Lim, K. H. C., & Halliwell, B. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6778 · Cited by 196 · see citing works
Chiurchiù, V., & Maccarrone, M. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3547 · Cited by 171 · see citing works
Li, Y., Wang, M., & Jiang, X. (2017) · ACS Catalysis · doi:10.1021/acscatal.7b02735 · Cited by 169 · see citing works
Wei, W., Cui, H., Yang, D., Yue, H., He, C., Zhang, Y., & Wang, H. (2017) · Green Chemistry · doi:10.1039/c7gc02330h · Cited by 163 · see citing works
Anti-Inflammatory Activity of Sulfur-Containing Compounds from Garlic
Lee, D. Y., Li, H., Lim, H. J., Lee, H. J., Jeon, R., & Ryu, J. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2012.2275 · Cited by 155 · see citing works
Francioso, A., Conrado, A. B., Mosca, L., & Fontana, M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8294158 · Cited by 153 · see citing works
Selective oxidation of (hetero)sulfides with molecular oxygen under clean conditions
Liu, K.-J., Deng, J.-H., Yang, J., Gong, S., Lin, Y., He, J., Cao, Z. Y., & He, W. (2019) · Green Chemistry · doi:10.1039/c9gc03713f · Cited by 147 · see citing works
Hu, W. J., Song, H., Her, A. S., Bak, D. W., Naowarojna, N., Elliott, S. J., Li, Q., Chen, X., & Liu, P. (2014) · Organic Letters · doi:10.1021/ol502596z · Cited by 118 · see citing works
Identification and Characterization of the First Ovothiol Biosynthetic Enzyme
Braunshausen, A., & Seebeck, F. P. (2011) · Journal of the American Chemical Society · doi:10.1021/ja109378e · Cited by 114 · see citing works
The Reactive Sulfur Species Concept: 15 Years On
Giles, G. I., Nasim, M. J., Ali, W., & Jacob, C. (2017) · Antioxidants · doi:10.3390/antiox6020038 · Cited by 113 · see citing works
Self-citationNew insight into sulfur nanoparticles: Synthesis and applications
Shankar, S., Jaiswal, L., & Rhim, J. (2020) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2020.1780880 · Cited by 102 · see citing works
Hydrogen sulfide donors in research and drug development
Song, Z. J., Ng, M. Y., Lee, Z., Dai, W., Hagen, T., Moore, P. K., Huang, D., Deng, L., & Tan, C. (2014) · MedChemComm · doi:10.1039/c3md00362k · Cited by 101 · see citing works
Visible-Light-Mediated Thiol–Ene Reactions through Organic Photoredox Catalysis
Zhao, G., Kaur, S., & Wang, T. (2017) · Organic Letters · doi:10.1021/acs.orglett.7b01441 · Cited by 99 · see citing works
Synthetic exploration of sulfinyl radicals using sulfinyl sulfones
Wang, Z., Zhang, Z., Zhao, W., Sivaguru, P., Zanoni, G., Wang, Y., Anderson, E. A., & Bi, X. (2021) · Nature Communications · doi:10.1038/s41467-021-25593-5 · Cited by 97 · see citing works
Visible-Light-Driven Photocatalytic Initiation of Radical Thiol–Ene Reactions Using Bismuth Oxide
Fadeyi, O., Mousseau, J. J., Feng, Y., Allais, C., Nuhant, P., Chen, M. Z., Pierce, B. S., & Robinson, R. P. (2015) · Organic Letters · doi:10.1021/acs.orglett.5b03184 · Cited by 96 · see citing works
Jacob, C., Battaglia, E., Burkholz, T., Peng, D., Bagrel, D., & Montenarh, M. (2011) · Chemical Research in Toxicology · doi:10.1021/tx200342b · Cited by 94 · see citing works
Self-citationPhotoinitiated Thiol‐Ene “Click” Reaction: An Organocatalytic Alternative
Limnios, D., & Kokotos, C. G. (2017) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201600977 · Cited by 94 · see citing works
Bhat, A. A., Shakeel, A., Waqar, S., Handoo, Z. A., & Khan, A. A. (2023) · Plants · doi:10.3390/plants12030451 · Cited by 91 · see citing works
Selective Antimicrobial Activity Associated with Sulfur Nanoparticles
Schneider, T. L., Baldauf, A., Ba, L. A., Jamier, V., Khairan, K., Sarakbi, M.-B., Reum, N., Schneider, M., Röseler, A., Becker, K., et al. (2011) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2011.1293 · Cited by 90 · see citing works
Self-citationCerella, C., Dicato, M. A., Jacob, C., & Diederich, M. F. (2011) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152011795347522 · Cited by 88 · see citing works
Self-citationMetal-Free Iodine-Catalyzed Synthesis of Fully Substituted Pyrazoles and Its Sulphenylation
Sun, J., Qiu, J., Zhu, Y., Guo, C., Hao, W.-J., Jiang, B., & Tu, S. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b01280 · Cited by 87 · see citing works
Yang, X., Qiu, Y., Zhao, Y., Chi, C., & Wang, B. (2019) · Marine Drugs · doi:10.3390/md17050251 · Cited by 86 · see citing works
On ovothiol biosynthesis and biological roles: from life in the ocean to therapeutic potential
Castellano, I., & Seebeck, F. P. (2018) · Natural Product Reports · doi:10.1039/c8np00045j · Cited by 84 · see citing works
Antifungal activity of redox-active benzaldehydes that target cellular antioxidation
Jong Heon, K. I. M., Chan, K. L., Mahoney, N. E., & Campbell, B. C. (2011) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/1476-0711-10-23 · Cited by 83 · see citing works
Chemical reactivity drives spatiotemporal organisation of bacterial metabolism
de Lorenzo, V., Sekowska, A., & Danchin, A. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12089 · Cited by 82 · see citing works
Visible-Light Induced Thiol–Ene Reaction on Natural Lignin
Liu, H., & Chung, H. (2017) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.7b02065 · Cited by 82 · see citing works
Allicin disrupts the cell's electrochemical potential and induces apoptosis in yeast
Gruhlke, M. C. H., Portz, D., Stitz, M., Anwar, A., Schneider, T. L., Jacob, C., Schlaich, N. L., & Slusarenko, A. J. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.019 · Cited by 79 · see citing works
Self-citationThe chemistry behind redox regulation with a focus on sulphur redox systems
Jacob, C., & Anwar, A. (2008) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2008.01080.x · Cited by 78 · see citing works
Self-citationRecent advances in pyrazole synthesis employing diazo compounds and synthetic analogues
Chandrasekharan, S. P., Dhami, A., Kumar, S., & Mohanan, K. (2022) · Organic & Biomolecular Chemistry · doi:10.1039/d2ob01918c · Cited by 77 · see citing works
Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis
Chen, L., Zhang, L., Ye, X., Deng, Z., & Zhao, C. (2023) · Protein & Cell · doi:10.1093/procel/pwad048 · Cited by 77 · see citing works
Structural analogues of diosgenyl saponins: Synthesis and anticancer activity
Kaskiw, M. J., Tassotto, M. L., Mok, M., Tokar, S. L., Pycko, R., Th'ng, J. P. H., & Jiang, Z. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.09.046 · Cited by 76 · see citing works
Naowarojna, N., Cheng, R., Chen, L., Quill, M., Xu, M., Zhao, C., & Liu, P. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00239 · Cited by 76 · see citing works
Rose, P., Moore, P. K., & Zhu, Y. Z. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.03.009 · Cited by 76 · see citing works
Wei, W., Cui, H., Yang, D., Liu, X., He, C., Dai, S., & Wang, H. (2016) · Organic Chemistry Frontiers · doi:10.1039/c6qo00403b · Cited by 75 · see citing works
Kumar, R., & Namboothiri, I. N. N. (2011) · Organic Letters · doi:10.1021/ol201534f · Cited by 75 · see citing works
Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells
Saidu, N. E. B., Valente, S., Bana, É., Kirsch, G., Bagrel, D., & Montenarh, M. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.12.032 · Cited by 74 · see citing works
Mechanistic Study of a Photocatalyzed CS Bond Formation Involving Alkyl/Aryl Thiosulfate
Li, Y., Xie, W., & Jiang, X. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201502951 · Cited by 74 · see citing works
A bioinspired and biocompatible ortho-sulfiliminyl phenol synthesis
Xiong, F., Lu, L., Sun, T., Wu, Q., Yan, D., Chen, Y., Zhang, X., Wei, W., Lu, Y., Sun, W., et al. (2017) · Nature Communications · doi:10.1038/ncomms15912 · Cited by 71 · see citing works
Recent Advances in Iodine‐Promoted C−S/N−S Bonds Formation
Zhang, H., Wang, H., Jiang, Y., Cao, F., Gao, W., Zhu, L., Yang, Y., Wang, X., Wang, Y., Chen, J., et al. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202001414 · Cited by 69 · see citing works
Cheng, B., Li, Y., Wang, T., Zhang, X., Li, H., Li, Y., & Zhai, H. (2019) · Chemical Communications · doi:10.1039/c9cc08326j · Cited by 67 · see citing works
Natural Products Impacting DNA Methyltransferases and Histone Deacetylases
Akoné, S. H., Ntie‐Kang, F., Stuhldreier, F., Ewonkem, M. B., Noah, A. M., Mouelle, S. E. M., & Müller, R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00992 · Cited by 67 · see citing works
Recent Advances in Visible-Light Photoredox Catalysis for the Thiol-Ene/Yne Reactions
Xiao, Q., Tong, Q., & Zhong, J. (2022) · Molecules · doi:10.3390/molecules27030619 · Cited by 67 · see citing works
Endogenous and Exogenous Antioxidants in Skeletal Muscle Fatigue Development during Exercise
Supruniuk, E., Górski, J., & Chabowski, A. (2023) · Antioxidants · doi:10.3390/antiox12020501 · Cited by 70 · see citing works
Wang, C., Wesener, S. R., Zhang, H., & Cheng, Y. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.05.005 · Cited by 64 · see citing works
Nielsen, R. W., Tachibana, C., Hansen, N. E., & Winther, J. R. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3677 · Cited by 63 · see citing works
Structural biology of plant sulfur metabolism: From assimilation to biosynthesis
Ravilious, G. E., & Jez, J. M. (2012) · Natural Product Reports · doi:10.1039/c2np20009k · Cited by 63 · see citing works
Natural Sulfur-Containing Compounds: An Alternative Therapeutic Strategy against Liver Fibrosis
Milito, A., Brancaccio, M., D’Argenio, G., & Castellano, I. (2019) · Cells · doi:10.3390/cells8111356 · Cited by 62 · see citing works
Ruiz, R., Garcia, M., Lara, A., & Rubio, L. A. (2009) · Veterinary Microbiology · doi:10.1016/j.vetmic.2009.12.025 · Cited by 61 · see citing works
Cheng, F., Kalita, S. J., Zhao, Z., Yang, X., Zhao, Y., Schneider, U., Shibata, N., & Huang, Y. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201908227 · Cited by 61 · see citing works
Metal-free photocatalytic thiol–ene/thiol–yne reactions
Kaur, S., Zhao, G., Busch, E., & Wang, T. (2018) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob02313a · Cited by 60 · see citing works
Antibacterial Activity of Phenyl Isothiocyanate on Escherichia coli and Staphylococcus aureus
Abreu, A. C., Borges, A. D. S., Simões, L. C., Saavedra, M. J., & Simões, M. V. (2013) · Medicinal Chemistry · doi:10.2174/1573406411309050016 · Cited by 60 · see citing works
Jönsson, T. J., Tsang, A. W., Lowther, W. T., & Furdui, C. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800124200 · Cited by 59 · see citing works
Cerella, C., Scherer, C., Cristofanon, S., Henry, E., Anwar, A., Busch, C., Montenarh, M., Dicato, M. A., Jacob, C., & Diederich, M. F. (2009) · APOPTOSIS · doi:10.1007/s10495-009-0328-8 · Cited by 57 · see citing works
Self-citationBaiju, T. V., & Namboothiri, I. N. N. (2017) · The Chemical Record · doi:10.1002/tcr.201600141 · Cited by 57 · see citing works
Essential Oils as Nematicides in Plant Protection—A Review
Catani, L., Manachini, B. R. I., Grassi, E., Guidi, L., & Semprucci, F. (2023) · Plants · doi:10.3390/plants12061418 · Cited by 55 · see citing works
Laurenza, I., Prato, S. D., Benzi, L., Colognato, R., & Migliore, L. (2008) · BioFactors · doi:10.1002/biof.5520330401 · Cited by 55 · see citing works
Perspectives on natural product epigenetic modulators in chemical biology and medicine
Cherblanc, F., Davidson, R. W. M., Fruscia, P. D., Srimongkolpithak, N., & Fuchter, M. J. (2013) · Natural Product Reports · doi:10.1039/c3np20097c · Cited by 55 · see citing works
Song, H., Hu, W. J., Naowarojna, N., Her, A. S., Wang, S., Desai, R. N., Li, Q., Chen, X., & Liu, P. (2015) · Scientific Reports · doi:10.1038/srep11870 · Cited by 55 · see citing works
Kimani, M. M., Wang, H. C., & Brumaghim, J. L. (2012) · Dalton Transactions · doi:10.1039/c2dt11731b · Cited by 54 · see citing works
Propargylic Sulfides: Synthesis, Properties, and Application
Ахметшакуровна, В. С., Sergeyevna, S. Y., Quntar, A. A. A. A., Kurmankulov, N. B., Yerzhanov, K. B., & Dembitsky, V. M. (2014) · Chemical Reviews · doi:10.1021/cr4001435 · Cited by 52 · see citing works
Ajith, T. A. (2020) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13373 · Cited by 50 · see citing works
Song, H., Her, A. S., Raso, F., Zhen, Z.-B., Huo, Y., & Liu, P. (2014) · Organic Letters · doi:10.1021/ol5005438 · Cited by 50 · see citing works
Xiao, Q., Zhang, H., Li, J., Jian, J., Tong, Q., & Zhong, J. (2021) · Organic Letters · doi:10.1021/acs.orglett.1c00999 · Cited by 50 · see citing works
Zhang, H., Yu, W., Lin, Y., & Jin, G. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202103264 · Cited by 49 · see citing works
Youn, H., Lim, H. J., Lee, H. J., Hwang, D. H., Yang, M., Jeon, R., & Ryu, J. (2008) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70434 · Cited by 49 · see citing works
Targeting the Oxidative Stress Response System of Fungi with Redox-Potent Chemosensitizing Agents
Jong Heon, K. I. M., Chan, K. L., Faria, N., Martins, M. D. L., & Campbell, B. C. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00088 · Cited by 49 · see citing works
Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism
Irani, S., Naowarojna, N., Tang, Y., Kathuria, K. R., Wang, S., Dhembi, A., Lee, N., Yan, W., Lyu, H., Costello, C. E., et al. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2018.02.002 · Cited by 48 · see citing works
Brancaccio, M., Russo, M., Masullo, M., Palumbo, A., Russo, G. L., & Castellano, I. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009304 · Cited by 48 · see citing works
Liu, S., Zhang, B., Xiao, W., Li, Y., & Deng, J. (2022) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.202200611 · Cited by 47 · see citing works
Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO3)3·9H2O
Liu, K., Meng, J., & Jiang, X. (2023) · Organic Process Research & Development · doi:10.1021/acs.oprd.2c00390 · Cited by 47 · see citing works
Use of Saliva Biomarkers to Monitor Efficacy of Vitamin C in Exercise-Induced Oxidative Stress
Evans, L., & Omaye, S. T. (2017) · Antioxidants · doi:10.3390/antiox6010005 · Cited by 47 · see citing works
Cheng, B., Zhang, X., Li, Y., Li, H., He, Y., Li, Y., Wang, T., & Zhai, H. (2020) · Chemical Communications · doi:10.1039/d0cc03446k · Cited by 47 · see citing works
Natural compounds in epigenetics: A current view
Miceli, M., Bontempo, P., Nebbioso, A., & Altucci, L. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.08.005 · Cited by 46 · see citing works
Castellano, I., Tomo, P. D., Pietro, N. D., Mandatori, D., Pipino, C., Formoso, G., Napolitano, A., Palumbo, A., & Pandolfi, A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2087373 · Cited by 46 · see citing works
Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis
Mashabela, G. T., & Seebeck, F. P. (2013) · Chemical Communications · doi:10.1039/c3cc42594k · Cited by 44 · see citing works
Visible light photocatalysis with benzophenone for radical thiol-ene reactions
Singh, M., Yadav, A. K., Yadav, L. D. S., & Singh, R. K. P. (2017) · Tetrahedron Letters · doi:10.1016/j.tetlet.2017.04.060 · Cited by 44 · see citing works
Model Iron–Oxo Species and the Oxidation of Imidazole: Insights into the Mechanism of OvoA and EgtB?
Bushnell, E. A. C., Fortowsky, G. B., & Gauld, J. W. (2012) · Inorganic Chemistry · doi:10.1021/ic3021172 · Cited by 44 · see citing works
Wu, X., Chen, M., He, F., & Wu, J. (2023) · Green Chemistry · doi:10.1039/d3gc03528j · Cited by 43 · see citing works
Oxidation induced by the antioxidant glutathione (GSH)
Petzold, H., & Sadler, P. J. (2008) · Chemical Communications · doi:10.1039/b805358h · Cited by 43 · see citing works
Asymmetric Organocatalytic Sulfa-Michael Addition to Enone Diesters
Fulton, J. L., Horwitz, M. A., Bruske, E. L., & Johnson, J. S. (2018) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.8b00007 · Cited by 43 · see citing works
Ni-Catalyzed cross-coupling of aryl thioethers with alkyl Grignard reagents via C–S bond cleavage
Zhu, D. Y., & Shi, L. (2018) · Chemical Communications · doi:10.1039/c8cc03665a · Cited by 43 · see citing works
Disulfide and multisulfide antitumor agents and their modes of action
Lee, S. H. (2009) · Archives of Pharmacal Research · doi:10.1007/s12272-009-1300-4 · Cited by 42 · see citing works
Chemosensitization of fungal pathogens to antimicrobial agents using benzo analogs
Jong Heon, K. I. M., Mahoney, N. E., Chan, K. L., Molyneux, R. J., May, G. S., & Campbell, B. C. (2008) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2008.01072.x · Cited by 41 · see citing works
Behnisch‐Cornwell, S., Bandaru, S. S. M., Napierkowski, M., Wolff, L., Zubair, M., Urbainsky, C., Lillig, C. H., Schulzke, C., & Bednarski, P. J. (2020) · ChemMedChem · doi:10.1002/cmdc.202000160 · Cited by 41 · see citing works
Yadan, J. (2021) · FEBS Letters · doi:10.1002/1873-3468.14264 · Cited by 40 · see citing works
Naowarojna, N., Huang, P., Cai, Y., Song, H., Wu, L., Cheng, R., Li, Y., Wang, S., Lyu, H., Zhang, L., et al. (2018) · Organic Letters · doi:10.1021/acs.orglett.8b02332 · Cited by 40 · see citing works
- Authors
- Jacob, C.
- Affiliations
- Saarland University (DE)
- Corresponding author
- Jacob, Claus
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2006
- Volume
- 23
- Issue
- 6
- Pages
- 851
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2145938995
- Cited by
- 373
- References
- 82
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 24 · 2023: 27 · 2022: 22 · 2021: 34 · 2020: 25 · 2019: 22 · 2018: 21 · 2017: 19 · 2016: 12 · 2015: 16 · 2014: 21 · 2013: 13 · 2012: 15
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Natural Product Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- sulfur-containing natural products, redox-active molecules, reactive sulfur species, ergothioneine, allicin, leinamycin, thiosulfinates, isothiocyanates, sulfenic acid, sulfinic acids, disulfides, antioxidant activity, antibacterial activity, antifungal activity, anticancer activity, oxidative stress, enzyme inhibition, radical formation, enzyme activation
- MeSH terms
- Bacteria, Biological Products, Fungi, Oxidation-Reduction, Plants, Sulfur, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review