Cited by 373Garlic and Onion StudiesSulfur Compounds in BiologyGenomics, phytochemicals, and oxidative stress

A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms

Jacob, Claus·2006·Natural Product Reports

Abstract

A range of sulfur-containing natural products from plants, fungi, bacteria and animals have recently been investigated to determine their therapeutic potential. Preliminary in vitro and in vivo studies of compounds such as ergothioneine, ovothiols, allicin, leinamycin, varacin, lenthionine and diallyltetrasulfide have provided evidence for antioxidant, antibacterial, antimicrobial, antifungal and anticancer properties. The biological activity of these compounds is the result of specific chemical properties which converge in chemotypes such as thiols, disulfides, sulfenic and sulfinic acids,thiosulfinates, sulfoxides, sulfones and polysulfides. Redox-activity, catalysis, metal binding, enzyme inhibition and radical generation allow reactive sulfur species to interact with oxidative stressors, to affect the function of redox-sensitive cysteine proteins and to disrupt the integrity of DNA and cellular membranes. In some cases, the biological activity of sulfur-containing plant products depends on initial enzymatic activation, which allows thiosulfinates and isothiocyanates to be generated with high target selectivity. Not surprisingly, research into the biochemical and pharmacological properties of the lesser known sulfur chemotypes is rapidly gathering momentum.

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  • ERG has an unusually high midpoint potential for a thiol, being +0·06 V.

    “Its midpoint potential for a thiol is consequently unusually high, being +0·06 V v. −0·2 to −0·4 V for typical thiols including glutathione(4,39–41) and mycothiol(42,43), and −0·193 V for the also somewhat oxidising thiol cofactor coenzyme M, which is 2-mercaptoethanesulfonate(44).”

    From The biology of ergothioneine, an antioxidant nutraceutical (2020) · cites this paper as [39]

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Authors
Jacob, C.
Affiliations
Saarland University (DE)
Corresponding author
Jacob, Claus
Venue
Natural Product Reports
Published
2006
Volume
23
Issue
6
Pages
851
ISSN
  • 0265-0568 (ISSN-L)
  • 1460-4752
OpenAlex
W2145938995
Cited by
373
References
82
Citations by year
2026: 18 · 2025: 21 · 2024: 24 · 2023: 27 · 2022: 22 · 2021: 34 · 2020: 25 · 2019: 22 · 2018: 21 · 2017: 19 · 2016: 12 · 2015: 16 · 2014: 21 · 2013: 13 · 2012: 15
FWCI
0.91
Type
journal article
Language
en
Open access
closed
Locations
  • Natural Product Reports (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords
sulfur-containing natural products, redox-active molecules, reactive sulfur species, ergothioneine, allicin, leinamycin, thiosulfinates, isothiocyanates, sulfenic acid, sulfinic acids, disulfides, antioxidant activity, antibacterial activity, antifungal activity, anticancer activity, oxidative stress, enzyme inhibition, radical formation, enzyme activation
MeSH terms
Bacteria, Biological Products, Fungi, Oxidation-Reduction, Plants, Sulfur, Oxidative Stress

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