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Cited by 15

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Coenzyme Q9 Provides Cardioprotection after Converting into Coenzyme Q10

Lekli, Istvan, Das, Somak, Das, Samarjit, Mukherjee, Subhendu, Bak, Istvan, Juhasz, Bela, Bagchi, Debasis, Trimurtulu, Golakoti, Krishnaraju, A. V., Sengupta, Krishanu, Tosaki, Arpad, Das, Dipak K.·2008·Journal of Agricultural and Food Chemistry
DOI 10.1021/jf800035f
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Abstract

Coenzyme Q10 (CoQ10) has been extensively studied as adjunctive therapy for ischemic heart disease, and its cardioprotective ability is well-established. The mitochondrial respiratory chain contains several coenzymes, including CoQ1, CoQ2, CoQ4, CoQ6, CoQ7, CoQ8, CoQ9, and CoQ10. It is not known whether other CoQs, especially CoQ9, is equally cardioprotective as CoQ10. The present study was designed to determine if CoQ 9 could protect guinea pig hearts from ischemia reperfusion injury. Guinea pigs were randomly divided into three groups: groups I and II were fed CoQ 9 and CoQ10, respectively, for 30 days while group III served as control. After 30 days, the guinea pigs were sacrificed and isolated hearts were perfused via working mode were subjected to 30 min ischemia followed by 2 h of reperfusion. Cardioprotection was assessed by evaluating left ventricular function, ventricular arrhythmias, myocardial infarct size, and cardiomyocyte apoptosis. Samples of hearts were examined for the presence of CoQ9 and CoQ10. The results demonstrated that both CoQ9 and CoQ10 were equally cardioprotective, as evidenced by their abilities to improve left ventricular performance and to reduce myocardial infarct size and cardiomyocyte apoptosis. High performance liquid chromatographic (HPLC) analysis revealed that a substantial portion of CoQ9 had been converted into CoQ10. The results indicate that CoQ9 by itself, or after being converted into CoQ10, reduced myocardial ischemia/reperfusion-i…

Overview

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Registry

Crossref · 10.1021/jf800035f

Cites

26 of 26 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 26 references

Research works printed but not linked: 7

  1. Engelman D. T., 1995, Cardiovasc. Res., 29, 133
  2. Sato M., 2000, Am. J. Physiol., 279, H901−H907
  3. Maulik N., 2000, Am. J. Physiol., 278, H1084−H1090
  4. Kitamura N., Biochemical and Clinical Aspects of Coenzyme Q, 4, 243
  5. Matsura T., 1992, Biochim. Biophys. Acta, 1123, 309, 10.1016/0005-2760(92)90012-K · DOI
  6. Simonsen R., 1991, Biochemical and Clinical Aspects of Coenzyme Q, 6, 363
  7. Walter L., 1998, J. Biol. Chem., 40, 25734

Cited by

Metadata

Authors
Lekli, I., Das, S., Das, S., Mukherjee, S., Bak, I., Juhasz, B., Bagchi, D., Trimurtulu, G., Krishnaraju, A. V., Sengupta, K., Tosaki, A., & Das, D. K.
Affiliations
Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, Connecticut, Department of Pharmacy, University of Debrecen, Debrecen, Hungary, InterHealth Nutraceuticals, Benicia, California, and Laila Impex R & D Center, Vijayawada, Andhra Pradesh, India
Venue
Journal of Agricultural and Food Chemistry
Publisher
American Chemical Society (ACS)
Published
2008-06-11
Volume
56
Issue
13
Pages
5331-5337
ISSN
  • 0021-8561
  • 1520-5118
DOI
10.1021/jf800035f
Cited by
15
References
26
Language
en

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.