The DOI matches its Crossref record.
Coenzyme Q10 in health and disease
Abstract
The literature concerning the importance of coenzyme Q10 in health and disease has been reviewed. Usual dietary intake together with normal in vivo synthesis seems to fulfil the demands for Q10 in healthy individuals. The importance of Q10 supplementation for general health has not been investigated in controlled experiments. The literature allows no firm conclusions about the significance of Q10 in physical activity. In different cardiovascular diseases, including cardiomyopathy, relatively low levels of Q10 in myocardial tissue have been reported. Positive clinical and haemodynamic effects of oral Q10 supplementation have been observed in double-blind trials, especially in chronic heart failure. These effects should be further examined. No important adverse effects have been reported from experiments using daily supplements of up to 200 mg Q10 for 6-12 months and 100 mg daily for up to 6 y.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Consistent with previous reports ( 44,46,47 ), CoQ 10 was the more abundant of the two ubiquinones, making up 94% of the total plasma CoQ.”
From Lipidomics reveals a remarkable diversity of lipids in human plasma (2010) · cites this paper as [46]
In the citing paper
“Clinical evidence suggests that CoQ 9 and CoQ 10 also possess cardioprotective properties, preventing ischemic damage to heart tissue and reducing ventricular dysfunction and cardiac arrhythmias associated with heart failure and acute myocardial infarction (44)(45)(46).”
From Lipidomics reveals a remarkable diversity of lipids in human plasma (2010) · cites this paper as [46]
In the citing paper
“Because the biosynthesis of CoQ is dependent upon the availability of farnesyl pyrophosphate produced by the mevalonate pathway, inhibition of the rate-limiting enzyme in this pathway, HMG-CoA reductase, by the cholesterol lowering statin drugs may lead to reductions in serum CoQ levels ( 46,47 ).”
From Lipidomics reveals a remarkable diversity of lipids in human plasma (2010) · cites this paper as [46]
Citations
Cited by
Lipidomics reveals a remarkable diversity of lipids in human plasma
Quehenberger, O., Armando, A. M., Brown, A. H., Milne, S. B., Myers, D. S., Merrill, A. H., Bandyopadhyay, S., Jones, K. N., Kelly, S., Shaner, R. L., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m009449 · Cited by 1,341
Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations
Bhagavan, H. N., & Chopra, R. K. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.03.003 · Cited by 243
Vollmer, D. L., West, V. A., & Lephart, E. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103059 · Cited by 132
Coenzyme Q10: From bench to clinic in aging diseases, a translational review
Gutierrez-Mariscal, F. M., Yubero-Serrano, E. M., Villalba, J. M., & Lopez-Miranda, J. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1442316 · Cited by 92
Yang, Y.-K., Wang, L.-P., Chen, L., Yao, X.-P., Yang, K.-Q., Gao, L.-G., & Zhou, X.-L. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.08.002 · Cited by 78
Metadata
- Authors
- Overvad, K., Diamant, B., Holm, L., Hølmer, G., Mortensen, S., & Stender, S.
- Venue
- European Journal of Clinical Nutrition
- Published
- 1999-10-01
- Volume
- 53
- Issue
- 10
- Pages
- 764-770
- ISSN
- 0954-3007
- 1476-5640
- Cited by
- 192
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Coenzyme Q10 in health and disease. https://app.cochat.ai/papers/10.1038/sj.ejcn.1600880
- The paper
- Overvad, K., Diamant, B., Holm, L., Hølmer, G., Mortensen, S., & Stender, S. (1999). Coenzyme Q10 in health and disease. European Journal of Clinical Nutrition. https://doi.org/10.1038/sj.ejcn.1600880
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
