Role of Iron and Hydroperoxides in the Degradation of Lycopene in Oil-in-Water Emulsions
Abstract
Lycopene has recently received interest as an antioxidant in human tissues. These antioxidant properties, however, present challenges to preventing oxidative degradation of lycopene within food products. In this research, oxidation of lycopene in a model emulsion system was examined. Lycopene loss was monitored using a spectrophotometer with an integrating sphere. Light was found to have little influence on the degradation of lycopene at pH 3, 5, or 7. The pH of the emulsion had a significant impact on the stability of lycopene, with most rapid degradation occurring in emulsions at pH 4 and below. Addition of EDTA significantly increased the stability of lycopene. Addition of TBHQ showed little impact on lycopene stability at pH 3, but exhibited a greater effect at pH 7. These results suggest that transition metal induced oxidation of lycopene may be the predominant mechanism of degradation at low pHs. At higher pHs, attack by free radicals was found to be a contributing mechanism to lycopene oxidation.
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HaCaT cells medium (DMEM) contains ferric nitrate and Fe(III) can react with excess neutral carotenoids such as lycopene.
“In fact, the HaCaT cells medium (DMEM) contains ferric nitrate (Fe(NO3)3·9 H2O) and Fe(III) can react with excess neutral carotenoids, such as lycopene.”
From The Effect of Lycopene Preexposure on UV‐B‐Irradiated Human Keratinocytes (2016) · cites this paper as [58]
EDTA used for HaCaT trypsinization can induce Fenton-chemistry mediated radical damage.
“The chelating agent used for HaCaT trypsinization was ethylenediaminetetraacetic acid (EDTA) which can induce Fenton-chemistry mediated radical damage.”
From The Effect of Lycopene Preexposure on UV‐B‐Irradiated Human Keratinocytes (2016) · cites this paper as [58]
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The Effect of Lycopene Preexposure on UV‐B‐Irradiated Human Keratinocytes
Ascenso, A., Pedrosa, T., Pinho, S., Pinho, F., Oliveira, J. M. P. F. D., Cabral Marques, H., Oliveira, H., Simões, S., & Santos, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8214631 · Cited by 57 · see citing works
- Authors
- Boon, C. S., McClements, D. J., Weiss, J., & Decker, E. A.
- Affiliations
- University of Massachusetts Amherst (US)
- Corresponding author
- Decker, Eric A.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-03-06
- Volume
- 57
- Issue
- 7
- Pages
- 2993-2998
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2084121825
- Cited by
- 122
- References
- 27
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 5 · 2020: 13 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 5 · 2013: 9 · 2012: 6
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Keywords
- lycopene, oxidative degradation, oil-in-water emulsions, iron, hydroperoxides, transition metal catalysis, pH effect, EDTA, tert-butylhydroquinone, free radicals, antioxidant stability, food colorants
- MeSH terms
- Lycopene, Antioxidants, Carotenoids, Drug Stability, Edetic Acid, Emulsions, Hydrogen Peroxide, Hydrogen-Ion Concentration, Hydroquinones, Iron, Light, Oxidation-Reduction
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