The DOI matches its Crossref record.
Antimicrobial and Cytotoxic Activities of Origanum Essential Oils
Abstract
Three Origanum essential oils, Origanum vulgare ssp . hirtum, Origanum dictamnus, and a commercially available Origanum oil, were analyzed by gas chromatography−mass spectrometry (GC−MS) and showed a high content of carvacrol, thymol, γ-terpinene, and p -cymene representing 73.7%, 92.8%, and 87.78% of the total oil, respectively. The three essential oils exhibited high levels of antimicrobial activity against eight strains of Gram-positive and Gram-negative bacteria. Among the major components of the three oils, carvacrol and thymol exhibited the highest levels of antimicrobial activity, while their biosynthetic precursors γ-terpinene and p -cymene were inactive . The essential oil of O. vulgare ssp. hirtum was extremely bactericidal at 1/4000 dilution and even at dilutions as high as 1/50000 caused considerable decrease in bacterial growth rates. The same essential oil also exhibited high levels of cytotoxicity against four permanent animal cell lines including two derived from human cancers. Keywords: Origanum vulgare; Origanum dictamus; essential oils; carvacrol; thymol; antimicrobial activity; cytotoxicity; terpenes; cancer
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Cited by
Essential oils: Their antibacterial properties and potential applications in foods—A review
Burt, S. (2004) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2004.03.022 · Cited by 10,488
Antimicrobial agents from plants: Antibacterial activity of plant volatile oils
Dorman, H. J. D., & Deans, S. G. (2000) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2000.00969.x · Cited by 4,334
Lambert, R. J. W., Skandamis, P. N., Coote, P. J., & Nychas, G.-J. E. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2001.01428.x · Cited by 2,449
Characterization of the action of selected essential oil components on Gram-negative bacteria
Helander, I. M., Alakomi, H.-L., Latva-Kala, K., Mattila-Sandholm, T., Pol, I., Smid, E. J., Gorris, L. G. M., & von Wright, A. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980154m · Cited by 1,664
Ultee, A., Bennik, M. H. J., & Moezelaar, R. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.4.1561-1568.2002 · Cited by 1,602
Metadata
- Authors
- Sivropoulou, A., Papanikolaou, E., Nikolaou, C., Kokkini, S., Lanaras, T., & Arsenakis, M.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1996-01-01
- Volume
- 44
- Issue
- 5
- Pages
- 1202-1205
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1974516740
- Cited by
- 666
- References
- 0
- FWCI
- 15.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sivropoulou, A., Papanikolaou, E., Nikolaou, C., Kokkini, S., Lanaras, T., & Arsenakis, M. (1996). Antimicrobial and Cytotoxic Activities of Origanum Essential Oils. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf950540t
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
