The DOI matches its Crossref record.
2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents
Abstract
Based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety also contribute to antimalarial activity.
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Metadata
- Authors
- Klayman, D. L., Bartosevich, J. F., Griffin, T. S., Mason, C. J., & Scovill, J. P.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1979-07
- Volume
- 22
- Issue
- 7
- Pages
- 855-862
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W1978067320
- Cited by
- 427
- References
- 0
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: 2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents. https://app.cochat.ai/papers/10.1021/jm00193a020
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- Klayman, D. L., Bartosevich, J. F., Griffin, T. S., Mason, C. J., & Scovill, J. P. (1979). 2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm00193a020
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
