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Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action

Adhikari, Hari Sharan, Yadav, Paras Nath·2018·International Journal of Biomaterials
DOI 10.1155/2018/2952085PMC PMC6332982
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Abstract

Tailoring of chitosan through the involvement of its amino, acetamido, and hydroxy groups can give derivatives of enhanced solubility and remarkable anticancer activity. The general mechanism of such activity is associated with the disturbances in normal functioning of cell cycle, interference to the central dogma of biological system from DNA to RNA to protein or enzymatic synthesis, and the disruption of hormonal path to biosynthesis to inhibit the growth of cancer cells. Both chitosan and its various derivatives have been reported to selectively permeate through the cancer cell membranes and show anticancer activity through the cellular enzymatic, antiangiogenic, immunoenhancing, antioxidant defense mechanism, and apoptotic pathways. They get sequestered from noncancer cells and provide their enhanced bioavailability in cancer cells in a sustained release manner. This review presents the putative mechanisms of anticancer activity of chitosan and mechanistic approaches of structure activity relation upon the modification of chitosan through functionalization, complex formation, and graft copolymerization to give different derivatives.

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Figures

Scheme 1 Steps involved in the preparation of chitosan.
Scheme 1 Steps involved in the preparation of chitosan.CC BY · PubMed Central
Figure 1 Structure of chitosan.
Figure 1 Structure of chitosan.CC BY · PubMed Central
Figure 2 Structure of chitin.
Figure 2 Structure of chitin.CC BY · PubMed Central
Figure 3 Deacetylation of chitin.
Figure 3 Deacetylation of chitin.CC BY · PubMed Central
Figure 4 Synthetic route to 2-phenylhydrazine (or hydrazine) thiosemicarbazone chitosan.
Figure 4 Synthetic route to 2-phenylhydrazine (or hydrazine) thiosemicarbazone chitosan.CC BY · PubMed Central
Figure 5 Structure of chitosan-metal complex.
Figure 5 Structure of chitosan-metal complex.CC BY · PubMed Central
Figure 6
Figure 6 CC BY · PubMed Central
Figure 7 Synthetic route of chitosan–thymine conjugate.
Figure 7 Synthetic route of chitosan–thymine conjugate.CC BY · PubMed Central
Figure 8 Synthetic route of sulfated chitosan (SCS) and sulfated benzaldehyde chitosan (SBCS).
Figure 8 Synthetic route of sulfated chitosan (SCS) and sulfated benzaldehyde chitosan (SBCS).CC BY · PubMed Central
Figure 9 Synthetic route of N-succinyl chitosan.
Figure 9 Synthetic route of N-succinyl chitosan.CC BY · PubMed Central
Figure 10 Synthetic route of glycol chitosan.
Figure 10 Synthetic route of glycol chitosan.CC BY · PubMed Central
Figure 11 Synthetic route to furanoallocolchicinoid chitosan.
Figure 11 Synthetic route to furanoallocolchicinoid chitosan.CC BY · PubMed Central
Figure 12 Graft copolymerization of polypyrrole-chitosan.
Figure 12 Graft copolymerization of polypyrrole-chitosan.CC BY · PubMed Central
Figure 13 (a) Heparan sulfate (HS). (b) Carboxymethyl benzylamide dextran (CMDB).
Figure 13 (a) Heparan sulfate (HS). (b) Carboxymethyl benzylamide dextran (CMDB).CC BY · PubMed Central

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Research works printed but not linked: 221

  1. 2012, International Journal of Scientific and Research Publications, 2, 1
  2. 10.3390/ma4081399 · DOI
  3. 2002, Journal of Dong Hua University (English Edition), 19, 36
  4. 2013, International journal of research in pharmaceutical and biomedical sciences, 4, 312
  5. 2011, Acta Poloniae Pharmaceutica, 68, 619
  6. 10.1016/j.ejpb.2008.03.004 · DOI
  7. 10.1016/j.biomaterials.2009.10.023 · DOI
  8. 10.1016/j.biomaterials.2006.03.028 · DOI
  9. 10.1016/j.addr.2009.10.003 · DOI
  10. 10.3390/ijms12010266 · DOI
  11. 10.1016/j.ejps.2010.08.011 · DOI
  12. 2012, International Journal of Oral Research, 3, e1
  13. 10.2334/josnusd.56.119 · DOI
  14. 10.1016/j.biortech.2008.01.011 · DOI
  15. 10.1021/bm060753z · DOI
  16. 10.1023/b:pham.0000016249.52831.a5 · DOI
  17. 2009, Anticancer Research, 29, 5103
  18. 10.1016/j.bbagen.2004.11.009 · DOI
  19. 10.1093/jn/134.4.945 · DOI
  20. 10.1016/s0141-8130(02)00064-8 · DOI
  21. 10.1016/j.biortech.2007.08.035 · DOI
  22. 10.1002/jbm.a.31234 · DOI
  23. 10.1016/j.ijbiomac.2009.08.002 · DOI
  24. 10.1016/j.matchemphys.2009.11.018 · DOI
  25. 2010, Carbohydrate Polymers, 80, 564
  26. 10.1080/10601325.2011.603623 · DOI
  27. 10.1016/j.ijbiomac.2008.09.007 · DOI
  28. 10.1016/j.carbpol.2009.08.026 · DOI
  29. 10.1016/j.ijbiomac.2006.06.021 · DOI
  30. 10.1016/j.biotechadv.2009.11.001 · DOI
  31. 10.1016/j.carbpol.2005.11.040 · DOI
  32. 10.1016/j.reactfunctpolym.2008.03.002 · DOI · Paper page
  33. 10.1021/bm9005535 · DOI
  34. 10.1016/j.carbpol.2005.07.017 · DOI
  35. 10.1016/j.ijbiomac.2007.12.011 · DOI
  36. 10.1016/j.ijbiomac.2007.09.003 · DOI
  37. 10.1016/j.biotechadv.2011.01.005 · DOI
  38. 10.1016/j.carbpol.2010.08.052 · DOI
  39. 10.1016/j.ijbiomac.2010.05.016 · DOI
  40. 10.1016/s0002-9343(00)00412-5 · DOI
  41. 2006, Advances in Pharmacology And Toxicology, 7, 29
  42. 10.1016/j.bmcl.2006.04.077 · DOI
  43. 10.1351/PAC-CON-08-11-15 · DOI
  44. 2004, Arkivoc, 2004, 66, 10.3998/ark.5550190.0005.910 · DOI
  45. 10.1016/j.carbpol.2015.04.040 · DOI
  46. 10.1016/j.ijbiomac.2012.01.015 · DOI
  47. 2011, Anticancer Research, 31, 1321
  48. 2005, In Vivo, 19, 301
  49. 10.4172/2161-0444.1000401 · DOI
  50. 2017, Nano, 12
  51. 10.1007/s00289-016-1804-2 · DOI
  52. 10.3390/molecules21030330 · DOI
  53. 10.1016/S0141-3910(02)00016-2 · DOI
  54. 10.1016/j.ijbiomac.2013.10.044 · DOI
  55. 10.1016/s0144-8617(03)00051-1 · DOI
  56. 10.1021/acs.bioconjchem.6b00251 · DOI
  57. 10.1080/10426500108055099 · DOI
  58. 10.1016/S0960-894X(98)00727-6 · DOI
  59. 10.1016/j.jorganchem.2015.07.012 · DOI
  60. 10.1211/0022357011776441 · DOI
  61. 10.1016/j.progpolymsci.2009.04.001 · DOI
  62. 10.1016/0142-9612(95)98126-Y · DOI
  63. 10.1016/S0378-5173(96)04847-8 · DOI
  64. 10.1248/cpb.40.2822 · DOI
  65. 10.1016/0378-5173(93)90048-K · DOI
  66. 1993, Yakuzaigaku, 53, 141
  67. 10.1248/bpb.22.179 · DOI
  68. 10.1016/s0142-9612(00)00044-2 · DOI
  69. 10.1248/bpb.18.1234 · DOI
  70. 10.1016/S0168-3659(01)00341-8 · DOI
  71. 10.1248/yakushi.126.789 · DOI
  72. 10.1248/bpb.16.48 · DOI
  73. 10.1016/S0144-8617(00)00331-3 · DOI
  74. 2011, International Journal of Nanomedicine, 6, 2697
  75. 10.1021/jm501678w · DOI
  76. 10.1016/j.carbpol.2014.05.098 · DOI
  77. 10.1016/s0169-409x(01)00180-6 · DOI
  78. 10.4014/jmb.0811.603 · DOI
  79. 10.3762/bjnano.7.178 · DOI
  80. 2013, Austrl-Asian Journal of Cancer, 12, 145
  81. 10.2147/IJN.S26365 · DOI
  82. 10.1016/j.fct.2009.04.044 · DOI
  83. 10.1016/s0308-8146(03)00181-x · DOI
  84. 10.1111/j.1348-0421.1988.tb01398.x · DOI
  85. 10.1016/S0304-3835(00)00551-6 · DOI
  86. 10.1016/S0008-6215(00)90359-8 · DOI
  87. 10.1111/j.1349-7006.1990.tb02559.x · DOI
  88. 10.1111/j.1348-0421.1989.tb01983.x · DOI
  89. 2001, Journal of Clinical Biochemistry Drug, 22, 21
  90. 10.3390/md10122661 · DOI
  91. 10.1093/ajcn/33.4.787 · DOI
  92. 10.2133/dmpk.19.76 · DOI
  93. 10.3390/md8071962 · DOI
  94. 10.1111/j.1349-7006.2001.tb01116.x · DOI
  95. 10.1016/j.ejca.2006.08.029 · DOI
  96. 10.1039/C6RA21648J · DOI
  97. 10.1016/j.actbio.2016.10.034 · DOI
  98. 10.1046/j.1365-2184.2003.00266.x · DOI
  99. 10.1002/hep.23769 · DOI
  100. 10.1016/S0955-0674(00)00280-5 · DOI
  101. 10.1101/gad.9.15.1831 · DOI · Paper page
  102. 10.1097/00006676-200405000-00009 · DOI
  103. 2007, Journal of Microbiology and Biotechnology, 17, 1546
  104. 2007, Journal of Microbiology and Biotechnology, 17, 2042
  105. 10.1016/j.mehy.2009.02.018 · DOI
  106. 10.1074/jbc.274.31.21491 · DOI
  107. 10.1136/gut.43.2.161 · DOI
  108. 2001, The American Surgeon, 67, 709, 10.1177/000313480106700726 · DOI · Paper page
  109. 10.1007/PL00008208 · DOI
  110. 1997, EXS, 79, 1
  111. 10.1038/aps.2011.10 · DOI
  112. 2008, Journal of Food and Drug Analysis, 16, 1
  113. 10.1016/j.carbpol.2011.03.008 · DOI
  114. 10.1006/bbrc.2000.2602 · DOI
  115. 10.1016/j.carbpol.2004.06.045 · DOI
  116. 10.1038/419790a · DOI
  117. 1956, Cancer Research, 16, 167
  118. 10.1021/jm00322a032 · DOI
  119. 10.1021/jm00305a011 · DOI
  120. 1971, Cancer Chemotherapy Reports Part 2, 2, 199
  121. 10.1021/jm00193a020 · DOI
  122. 10.1146/annurev.bi.48.070179.001025 · DOI
  123. 10.1007/BF00225258 · DOI
  124. 1989, The inhibition of ribonucleotide reductase by alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones, 203
  125. 10.1016/S0960-894X(01)00285-2 · DOI
  126. 10.3892/or.2013.2279 · DOI
  127. 10.1021/cr020010d · DOI
  128. 10.1016/j.mpmed.2007.10.007 · DOI
  129. 10.1351/pac200880122715 · DOI
  130. 10.1351/pac200779122243 · DOI
  131. 10.1021/cr9903050 · DOI
  132. 10.1016/j.ccr.2007.07.015 · DOI
  133. 10.1016/j.carbpol.2003.08.005 · DOI
  134. 10.1016/j.carbpol.2017.09.095 · DOI
  135. 10.1016/j.carres.2004.09.007 · DOI
  136. 10.1016/s0092-8674(00)81684-0 · DOI
  137. 10.1007/978-1-4020-9674-7 · DOI
  138. 10.1007/s00204-013-1079-4 · DOI
  139. 10.11113/mjfas.v10n4.277 · DOI
  140. 10.1002/app.36556 · DOI
  141. 10.1163/092050611X581534 · DOI
  142. 10.1016/j.colsurfb.2012.01.032 · DOI
  143. 10.1016/j.carbpol.2011.06.080 · DOI
  144. 10.1016/j.carbpol.2011.04.038 · DOI
  145. 10.1016/S0959-8049(96)00423-6 · DOI
  146. 10.1016/S0047-6374(02)00171-9 · DOI
  147. 10.1200/JCO.1989.7.12.1875 · DOI
  148. 10.1200/JCO.1996.14.10.2653 · DOI
  149. 10.4049/jimmunol.176.7.4331 · DOI
  150. 10.1101/gad.1062403 · DOI
  151. 10.1006/excr.1994.1309 · DOI
  152. 10.1002/ijc.10516 · DOI
  153. 10.1016/j.tet.2010.01.063 · DOI
  154. 10.1002/1521-3765(20020703)8:13<2891::AID-CHEM2891>3.0.CO;2-B · DOI
  155. 10.3762/bjoc.6.34 · DOI
  156. 10.1021/ja809023n · DOI
  157. 10.1007/s10904-004-2380-8 · DOI
  158. 10.1093/nar/gnf058 · DOI
  159. 10.1016/j.tet.2009.04.084 · DOI
  160. 2003, Nucleic Acids Research, 179
  161. 10.1007/s00726-010-0567-6 · DOI
  162. 2005, DNA Replication, in: Lehninger Principles of Biochemistry, 950
  163. 10.1016/j.cell.2011.02.013 · DOI · Paper page
  164. 10.1016/0955-2235(94)00007-8 · DOI
  165. 10.1074/jbc.M211259200 · DOI
  166. 10.1016/S0002-9440(10)64362-3 · DOI
  167. 10.1038/bjc.1996.204 · DOI
  168. 10.1016/j.amjsurg.2004.07.007 · DOI
  169. 1997, Clinical Cancer Research, 3, 2347
  170. 2001, Oncology Reports, 8, 161
  171. 2005, Anticancer Reseach, 25, 2129
  172. 10.1038/sj.bjc.6600985 · DOI
  173. 10.1006/bbrc.1997.7866 · DOI
  174. 10.1097/00001813-199212000-00011 · DOI
  175. 10.1016/S0008-6215(99)00200-1 · DOI
  176. 1997, Anticancer Reseach, 17, 253
  177. 10.1038/sj.bjp.0704645 · DOI
  178. 10.1097/00001813-200411000-00007 · DOI
  179. 10.1097/00001813-200201000-00004 · DOI
  180. 10.1054/bjoc.2001.1993 · DOI
  181. 10.1016/S0006-2952(99)00051-9 · DOI
  182. 10.1016/j.bbagen.2008.01.015 · DOI
  183. 10.1002/(SICI)1097-4636(1999)48:4<578::AID-JBM26>3.0.CO;2-8 · DOI
  184. 10.1016/0168-3659(96)01372-7 · DOI
  185. 1994, International Journal of Clinical Pharmacology and Therapeutics, 32, 429
  186. 10.1038/clpt.1993.161 · DOI
  187. 10.2174/156800912801784893 · DOI
  188. 10.4155/fmc.12.217 · DOI
  189. 10.1007/s10549-011-1875-6 · DOI
  190. 10.2174/138161212800626193 · DOI
  191. 1975, Journal of Polymer Science: Polymer Symposia, 51, 135
  192. 10.1002/poc.3702 · DOI
  193. 10.1016/j.nantod.2008.10.014 · DOI
  194. 10.1073/pnas.91.8.3201 · DOI
  195. 10.1002/jbm.a.30286 · DOI
  196. 2013, Journal of Chemical and Pharmaceutical Research, 5, 140
  197. 2014, Iranian Journal of Pharmaceutical Research, 13, 819
  198. 10.1016/S0378-5173(99)00447-0 · DOI
  199. 10.1021/jm800767c · DOI
  200. 10.1016/j.carbpol.2008.12.034 · DOI

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Metadata

Authors
Adhikari, H. S., & Yadav, P. N.
Venue
International Journal of Biomaterials
Publisher
Wiley
Published
2018-12-30
Volume
2018
Pages
1-29
ISSN
  • 1687-8787
  • 1687-8795
DOI
10.1155/2018/2952085
PMC
PMC6332982
Cited by
313
References
5
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)
Funders
Nepal Academy of Science and Technology

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CoChat. (2026). Citation check: Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action. https://app.cochat.ai/papers/10.1155/2018/2952085
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Adhikari, H. S., & Yadav, P. N. (2018). Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action. International Journal of Biomaterials. https://doi.org/10.1155/2018/2952085