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Designing Non-Peptide Peptidomimetics in the 21st Century: Inhibitors Targeting Conformational Ensembles
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ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTDesigning Non-Peptide Peptidomimetics in the 21st Century: Inhibitors Targeting Conformational EnsemblesMatthew G. Bursavich and Daniel H. RichView Author Information Department of Chemistry and School of Pharmacy, University of WisconsinMadison, Madison, Wisconsin 53706 Cite this: J. Med. Chem. 2002, 45, 3, 541–558Publication Date (Web):January 24, 2002Publication History Received10 September 2001Published online24 January 2002Published inissue 1 January 2002https://pubs.acs.org/doi/10.1021/jm010425bhttps://doi.org/10.1021/jm010425breview-articleACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views1966Altmetric-Citations180LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Conformation,Inhibitors,Peptides and proteins,Peptidomimetics,Receptors Get e-Alerts
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Cites
Folding funnels and conformational transitions via hinge-bending motions
Kumar, S., Ma, B., Tsai, C.-J., Wolfson, H., & Nussinov, R. (1999) · Cell Biochemistry and Biophysics · doi:10.1007/bf02738169 · Cited by 94
Cited by
The role of dynamic conformational ensembles in biomolecular recognition
Boehr, D. D., Nussinov, R., & Wright, P. E. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.232 · Cited by 2,008
Implications of protein flexibility for drug discovery
Teague, S. J. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1129 · Cited by 755
Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
Norman, A. W., Mizwicki, M. T., & Norman, D. P. G. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1283 · Cited by 569
Moitessier, N., Englebienne, P., Lee, D., Lawandi, J., & Corbeil, C. R. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707515 · Cited by 514
Binding of small molecules to an adaptive protein–protein interface
Arkin, M. R., Randal, M., DeLano, W. L., Hyde, J., Luong, T. N., Oslob, J. D., Raphael, D. R., Taylor, L., Wang, J., McDowell, R. S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252756299 · Cited by 375
Metadata
- Authors
- Bursavich, M. G., & Rich, D. H.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-01-01
- Volume
- 45
- Issue
- 3
- Pages
- 541-558
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W1989003785
- Cited by
- 208
- References
- 1
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- green
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