The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Synthesis and Antimycobacterial Activity of Pyrazine and Quinoxaline Derivatives
Abstract
A series of pyrazine and quinoxaline derivatives have been synthesized, and their activity against M. tuberculosis (Mtb) and Mycobacterium avium (MAC) are reported. The 4-acetoxybenzyl ester of pyrazinoic acid and 4'-acetoxybenzyl 2-quinoxalinecarboxylate showed excellent activity against Mtb (MIC ranges of less than 1-6.25 microg/mL) but only modest activity against MAC (MICs of 4-32 microg/mL).
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Cites
Scorpio, A., & Zhang, Y. (1996) · Nature Medicine · doi:10.1038/nm0696-662 · Cited by 726
Tuberculosis: Latency and Reactivation
Flynn, J. L., & Chan, J. (2001) · Infection and Immunity · doi:10.1128/iai.69.7.4195-4201.2001 · Cited by 500
Comparison of Reliability of log P Values for Drugs Calculated by Several Methods.
MORIGUCHI, I., HIRONO, S., NAKAGOME, I., & HIRANO, H. (1994) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.42.976 · Cited by 278
Zimhony, O., Cox, J. S., Welch, J. T., Vilchèze, C., & Jacobs, W. R. (2000) · Nature Medicine · doi:10.1038/79558 · Cited by 270
Rosenkrands, I., Slayden, R. A., Crawford, J., Aagaard, C., Barry, C. E., & Andersen, P. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.13.3485-3491.2002 · Cited by 175
The role of hypoxia-activated prodrugs in cancer therapy
Denny, W. A. (2000) · The Lancet Oncology · doi:10.1016/s1470-2045(00)00006-1 · Cited by 167
Use of genomics and combinatorial chemistry in the development of new antimycobacterial drugs
Barry, C. E., Slayden, R. A., Sampson, A. E., & Lee, R. E., Jr. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00253-1 · Cited by 136
Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG
Murugasu-Oei, B. (2000) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/46.6.917 · Cited by 87
Maccari, R., Ottanà, R., Monforte, F., & Vigorita, M. G. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.2.294-299.2002 · Cited by 70
Ethambutol–sugar hybrids as potential inhibitors of mycobacterial cell-wall biosynthesis
Reynolds, R. C., Bansal, N., Rose, J. D., Friedrich, J. D., Suling, W. J., & Maddry, J. A. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00069-5 · Cited by 45
Self-citation
Metadata
- Authors
- Seitz, L. E., Suling, W. J., & Reynolds, R. C.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-11-07
- Volume
- 45
- Issue
- 25
- Pages
- 5604-5606
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W1977750472
- Cited by
- 441
- References
- 11
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Seitz, L. E., Suling, W. J., & Reynolds, R. C. (2002). Synthesis and Antimycobacterial Activity of Pyrazine and Quinoxaline Derivatives. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm020310n
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
