The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hypoxic Response of Mycobacterium tuberculosis Studied by Metabolic Labeling and Proteome Analysis of Cellular and Extracellular Proteins
Open accessAbstract
The events involved in the establishment of a latent infection with Mycobacterium tuberculosis are not fully understood, but hypoxic conditions are generally believed to be the environment encountered by the pathogen in the central part of the granuloma. The present study was undertaken to provide insight into M. tuberculosis protein expression in in vitro latency models where oxygen is depleted. The response of M. tuberculosis to low-oxygen conditions was investigated in both cellular and extracellular proteins by metabolic labeling, two-dimensional electrophoresis, and protein signature peptide analysis by liquid chromatography-mass spectrometry. By peptide mass fingerprinting and immunodetection, five proteins more abundant under low-oxygen conditions were identified from several lysates of M. tuberculosis: Rv0569, Rv2031c (HspX), Rv2623, Rv2626c, and Rv3841 (BfrB). In M. tuberculosis culture filtrates, two additional proteins, Rv0363c (Fba) and Rv2780 (Ald), were found in increased amounts under oxygen limitation. These results extend our understanding of the hypoxic response in M. tuberculosis and potentially provide important insights into the physiology of the latent bacilli.
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Cites
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
Self-citationWayne, L. G., & Hayes, L. G. (1996) · Infection and Immunity · doi:10.1128/iai.64.6.2062-2069.1996 · Cited by 1,141
Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis
Mahairas, G. G., Sabo, P. J., Hickey, M. J., Singh, D. C., & Stover, C. K. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.5.1274-1282.1996 · Cited by 1,103
Cited by
Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence
Smith, I. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.3.463-496.2003 · Cited by 1,154
Synthesis and Antimycobacterial Activity of Pyrazine and Quinoxaline Derivatives
Seitz, L. E., Suling, W. J., & Reynolds, R. C. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020310n · Cited by 441
Puckett, S., Trujillo, C., Eoh, H., Marrero, J., Spencer, J., Jackson, M., Schnappinger, D., Rhee, K., & Ehrt, S. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004144 · Cited by 72
Metadata
- Authors
- Rosenkrands, I., Slayden, R. A., Crawford, J., Aagaard, C., Barry, C. E., & Andersen, P.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2002-07
- Volume
- 184
- Issue
- 13
- Pages
- 3485-3491
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2098732312
- Cited by
- 175
- References
- 3
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Rosenkrands, I., Slayden, R. A., Crawford, J., Aagaard, C., Barry, C. E., & Andersen, P. (2002). Hypoxic Response of Mycobacterium tuberculosis Studied by Metabolic Labeling and Proteome Analysis of Cellular and Extracellular Proteins. Journal of Bacteriology. https://doi.org/10.1128/jb.184.13.3485-3491.2002
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