The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of a Selective Inverse Agonist for the Orphan Nuclear Receptor Estrogen-Related Receptor α
Open accessAbstract
The estrogen-related receptor alpha (ERRalpha) is an orphan receptor belonging to the nuclear receptor superfamily. The physiological role of ERRalpha has yet to be established primarily because of lack of a natural ligand. Herein, we describe the discovery of the first potent and selective inverse agonist of ERRalpha. Through in vitro and in vivo studies, these ligands will elucidate the endocrine signaling pathways mediated by ERRalpha including association with human disease states.
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Cites
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Cited by
Nuclear receptors — a perspective from Drosophila
King-Jones, K., & Thummel, C. S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1581 · Cited by 586
Tennessen, J. M., Baker, K. D., Lam, G., Evans, J., & Thummel, C. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.005 · Cited by 289
De Luca, A., Fiorillo, M., Peiris-Pagès, M., Ozsvari, B., Smith, D. L., Sanchez-Alvarez, R., Martinez-Outschoorn, U. E., Cappello, A. R., Pezzi, V., Lisanti, M. P., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4401 · Cited by 259
ERRα: a metabolic function for the oldest orphan
Villena, J. A., & Kralli, A. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.07.005 · Cited by 252
Michalek, R. D., Gerriets, V. A., Nichols, A. G., Inoue, M., Kazmin, D., Chang, C.-Y., Dwyer, M. A., Nelson, E. R., Pollizzi, K. N., Ilkayeva, O., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108856108 · Cited by 216
Metadata
- Authors
- Busch, B. B., Stevens, Martin, R., Ordentlich, P., Zhou, S., Sapp, D. W., Horlick, R. A., & Mohan, R.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-10-01
- Volume
- 47
- Issue
- 23
- Pages
- 5593-5596
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W1991108075
- Cited by
- 173
- References
- 1
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Busch, B. B., Stevens, Martin, R., Ordentlich, P., Zhou, S., Sapp, D. W., Horlick, R. A., & Mohan, R. (2004). Identification of a Selective Inverse Agonist for the Orphan Nuclear Receptor Estrogen-Related Receptor α. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm049334f
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