The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
The Drosophila Estrogen-Related Receptor Directs a Metabolic Switch that Supports Developmental Growth
Open accessAbstract
Summary Metabolism must be coordinated with development to provide the appropriate energetic needs for each stage in the life cycle. Little is know, however, about how this temporal control is achieved. Here we show that the Drosophila ortholog of the Estrogen-Related Receptor (ERR) family of nuclear receptors directs a critical metabolic transition during development. dERR mutants die as larvae with low ATP levels and elevated levels of circulating sugars. The expression of active dERR protein in mid-embryogenesis triggers a coordinate switch in gene expression that drives a metabolic program normally associated with proliferating cells, supporting the dramatic growth that occurs during larval development. This study shows that dERR plays a central role in carbohydrate metabolism, demonstrates that a proliferative metabolic program is used in normal developmental growth, and provides a molecular context to understand the close association between mammalian ERR family members and cancer.
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Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F., Ben Miled, S., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,803
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,266
Summaries of Affymetrix GeneChip probe level data
Irizarry, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng015 · Cited by 4,887
Insect Fat Body: Energy, Metabolism, and Regulation
Arrese, E. L., & Soulages, J. L. (2010) · Annual Review of Entomology · doi:10.1146/annurev-ento-112408-085356 · Cited by 2,514
Nuclear Receptors and Lipid Physiology: Opening the X-Files
Chawla, A., Repa, J. J., Evans, R. M., & Mangelsdorf, D. J. (2001) · Science · doi:10.1126/science.294.5548.1866 · Cited by 2,085
Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor α.
Luo, J., Sladek, R., Carrier, J., Bader, J.-A., Richard, D., & Giguère, V. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.7947-7956.2003 · Cited by 370
Nutritional programming of the metabolic syndrome
Symonds, M. E., Sebert, S. P., Hyatt, M. A., & Budge, H. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.195 · Cited by 368
Cited by
Metabolic Regulation of T Lymphocytes
MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244
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Methods for studying metabolism in Drosophila
Tennessen, J. M., Barry, W. E., Cox, J., & Thummel, C. S. (2014) · Methods · doi:10.1016/j.ymeth.2014.02.034 · Cited by 445
Self-citationMichalek, R. D., Gerriets, V. A., Nichols, A. G., Inoue, M., Kazmin, D., Chang, C.-Y., Dwyer, M. A., Nelson, E. R., Pollizzi, K. N., Ilkayeva, O., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108856108 · Cited by 216
Saul, M. C., Seward, C. H., Troy, J. M., Zhang, H., Sloofman, L. G., Lu, X., Weisner, P. A., Caetano-Anolles, D., Sun, H., Zhao, S. D., et al. (2017) · Genome Research · doi:10.1101/gr.214221.116 · Cited by 46
Metadata
- Authors
- Tennessen, J. M., Baker, K. D., Lam, G., Evans, J., & Thummel, C. S.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 13
- Issue
- 2
- Pages
- 139-148
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2012355682
- Cited by
- 289
- References
- 38
- FWCI
- 8.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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