The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs
Open accessAbstract
Structures of human monoamine oxidase B (MAO B) in complex with safinamide and two coumarin derivatives, all sharing a common benzyloxy substituent, were determined by X-ray crystallography. These compounds competitively inhibit MAO B with Ki values in the 0.1-0.5 microM range that are 30-700-fold lower than those observed with MAO A. The inhibitors bind noncovalently to MAO B, occupying both the entrance and the substrate cavities and showing a similarly oriented benzyloxy substituent.
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Cites
The therapeutic potential of monoamine oxidase inhibitors
Youdim, M. B. H., Edmondson, D., & Tipton, K. F. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1883 · Cited by 1,363
Self-citationStructure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
Binda, C., Newton-Vinson, P., Hubálek, F., Edmondson, D. E., & Mattevi, A. (2002) · Nature Structural Biology · doi:10.1038/nsb732 · Cited by 644
Self-citationRascol, O., Brooks, D., Melamed, E., Oertel, W., Poewe, W., Stocchi, F., & Tolosa, E. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71083-7 · Cited by 641
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Self-citationBinda, C., Li, M., Hubálek, F., Restelli, N., Edmondson, D. E., & Mattevi, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1633804100 · Cited by 397
Self-citationClinical Pharmacology of MAO Inhibitors: Safety and Future
Yamada, M. (2004) · NeuroToxicology · doi:10.1016/s0161-813x(03)00097-4 · Cited by 324
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase
Brühlmann, C., Ooms, F., Carrupt, P.-A., Testa, B., Catto, M., Leonetti, F., Altomare, C., & Carotti, A. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm010894d · Cited by 290
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Self-citationBinda, C., Hubálek, F., Li, M., Herzig, Y., Sterling, J., Edmondson, D. E., & Mattevi, A. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm031087c · Cited by 214
Self-citationSafinamide: From molecular targets to a new anti-Parkinson drug
Caccia, C., Maj, R., Calabresi, M., Maestroni, S., Faravelli, L., Curatolo, L., Salvati, P., & Fariello, R. G. (2006) · Neurology · doi:10.1212/wnl.67.7_suppl_2.s18 · Cited by 195
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Ramírez, D., & Caballero, J. (2018) · Molecules · doi:10.3390/molecules23051038 · Cited by 624
Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology
Finberg, J. P. M., & Rabey, J. M. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00340 · Cited by 432
Behl, T., Kaur, D., Sehgal, A., Singh, S., Sharma, N., Zengin, G., Andronie-Cioara, F. L., Toma, M. M., Bungau, S., & Bumbu, A. G. (2021) · Molecules · doi:10.3390/molecules26123724 · Cited by 317
Ramsay, R., & Tipton, K. (2017) · Molecules · doi:10.3390/molecules22071192 · Cited by 258
In silico repurposing of antipsychotic drugs for Alzheimer’s disease
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Metadata
- Authors
- Binda, C., Wang, J., Pisani, L., Caccia, C., Carotti, A., Salvati, P., Edmondson, D. E., & Mattevi, A.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-10-04
- Volume
- 50
- Issue
- 23
- Pages
- 5848-5852
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2042386533
- Cited by
- 607
- References
- 14
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Binda, C., Wang, J., Pisani, L., Caccia, C., Carotti, A., Salvati, P., Edmondson, D. E., & Mattevi, A. (2007). Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm070677y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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