The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase
Open accessAbstract
A set of 17 coumarin and 2 chromone derivatives with known inhibitory activity toward monoamine oxidase (MAO) A and B were tested as acetylcholinesterase (AChE) inhibitors. All compounds inhibited AChE with values in the micromolar range (3-100 microM). A kinetic study showed that most compounds acted as noncompetitive AChE inhibitors. This finding may be of interest in the context of Alzheimer's disease because recent observations suggest that MAO and AChE inhibition might decrease beta-amyloid deposition.
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Cites
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,126
The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545
Amyloid, the presenilins and Alzheimer’s disease
Hardy, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01030-2 · Cited by 1,370
Inestrosa, N. C., Alvarez, A., Pérez, C. A., Moreno, R. D., Vicente, M., Linker, C., Casanueva, O. I., Soto, C., & Garrido, J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80108-7 · Cited by 1,101
Amyloid β-Protein and the Genetics of Alzheimer's Disease
Selkoe, D. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18295 · Cited by 799
Saura, J., Luque, J. M., Cesura, A. M., Prada, M. D., Chan-Palay, V., Huber, G., Löffler, J., & Richards, J. G. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90311-5 · Cited by 382
Gnerre, C., Catto, M., Leonetti, F., Weber, P., Carrupt, P.-A., Altomare, C., Carotti, A., & Testa, B. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm001028o · Cited by 262
Self-citationThe role of neurotrophic factors in regulating the development of inner ear innervation
Fritzsch, B. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01007-7 · Cited by 208
Cholinergic activity and amyloid precursor protein metabolism
Roberson, M. R. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00016-7 · Cited by 127
KA-672 inhibits rat brain acetylcholinesterase in vitro but not in vivo
Hilgert, M., Nöldner, M., Chatterjee, S. S., et al. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00149-4 · Cited by 35
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Self-citationA review on coumarins as acetylcholinesterase inhibitors for Alzheimer’s disease
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Metadata
- Authors
- Brühlmann, C., Ooms, F., Carrupt, P.-A., Testa, B., Catto, M., Leonetti, F., Altomare, C., & Carotti, A.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2001-08-21
- Volume
- 44
- Issue
- 19
- Pages
- 3195-3198
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W1998253336
- Cited by
- 290
- References
- 10
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Brühlmann, C., Ooms, F., Carrupt, P.-A., Testa, B., Catto, M., Leonetti, F., Altomare, C., & Carotti, A. (2001). Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm010894d
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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