Targeting Peroxisome Proliferator-Activated Receptors (PPARs): Development of Modulators

Cited by (235)

Items 101–200 of 235

1. Small-Molecule Modulation of PPARs for the Treatment of Prevalent Vascular Retinal Diseases
   Xiaozheng Dou, Adam S. Duerfeldt · 2020 · International Journal of Molecular Sciences
2. PPARα/δ dual agonist H11 alleviates diabetic kidney injury by improving the metabolic disorders of tubular epithelial cells
   Qingqing Ke, Yu Xiao, Dandan Liu, Caifeng Shi, Rui Shen, Songyan Qin, Lei Jiang, Junwei Yang, Yang Zhou · 2024 · Biochemical Pharmacology
3. Design and Synthesis of Highly Active Peroxisome Proliferator‐Activated Receptor (PPAR) β/δ Inverse Agonists with Prolonged Cellular Activity
   Philipp M. Toth, Sonja Lieber, Frithjof M. Scheer, Tim Schumann, Yvonne Schober, Wolfgang Andreas Nockher, Till Adhikary, Sabine Müller‐Brüsselbach, Rolf Müller, Wibke E. Diederich · 2016 · ChemMedChem
4. PPARs at the crossroads of T cell differentiation and type 1 diabetes
   Farooq Riaz, Ping Yen Wei, Fan Pan · 2023 · Frontiers in Immunology
5. Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification
   Tsuyoshi Shinozuka, Tomoharu Tsukada, Kunihiko Fujii, Eri Tokumaru, Kousei Shimada, Yoshiyuki Onishi, Yumi Matsui, Satoko Wakimoto, Masanori Kuroha, Tsuneaki Ogata et al. · 2018 · Bioorganic & Medicinal Chemistry
6. Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological Evaluation
   Nieves Fresno, Manuel Macías‐González, A. Torres-Zaguirre, Miguel Romero Cuevas, Paula Sanz Camacho, José Elguero, Francisco Javier Pavón, Fernando Rodrı́guez de Fonseca, Pilar Goya, Ruth Pérez‐Fernández · 2015 · Journal of Medicinal Chemistry
7. Peroxisome proliferator‐activated receptor α ligands and modulators from dietary compounds: T ypes, screening methods and functions
   Haixia Yang, Lei Xiao, Nanping Wang · 2016 · Journal of Diabetes
8. GED-0507 attenuates lung fibrosis by counteracting myofibroblast transdifferentiation in vivo and in vitro
   Silvia Speca, Caroline Dubuquoy, Christel Rousseaux, Philippe Chavatte, Pierre Desreumaux, Paolo Spagnolo · 2021 · PLoS ONE
9. Effect of Oxime Ether Incorporation in Acyl Indole Derivatives on PPAR Subtype Selectivity
   Morgan Le Naour, Véronique Leclerc, Amaury Farce, Daniel‐Henri Caignard, Nathalie Hennuyer, Bart Staels, Valérie Audinot, Jean Albert Boutin, Michel Lonchampt, Catherine Dacquet et al. · 2012 · ChemMedChem
10. Biocatalyzed synthesis of antidiabetic drugs: A review
    Cristina Alcántara, Andrés R. Alcántara · 2017 · Biocatalysis and Biotransformation
11. Peroxisome Proliferator-activated Receptor-γ As A Novel and Promising Target For Treating Cancer Via Regulation of Inflammation: A Brief Review
    S. Yuvaraj, B. R. Prashantha Kumar · 2021 · Mini-Reviews in Medicinal Chemistry
12. Cross-Talk between Obesity and Diabetes: Introducing Polyphenols as an Effective Phytomedicine to Combat the Dual Sword Diabesity
    Muhammad Ajmal Shah, Muhammad Naoval Haris, Hafiza Ishmal Faheem, Ayesha Hamid, Rimsha Yousaf, Azhar Rasul, Ghulam Mujtaba Shah, Atif Ali Khan Khalil, Abdul Wahab, Haroon Zaman Khan et al. · 2022 · Current Pharmaceutical Design
13. Novel highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulators with pharmacokinetic properties suitable for once-daily oral dosing
    Bharat R. Lagu, Arthur F. Kluge, Ross A. Fredenburg, Effie Tozzo, Ramesh S. Senaiar, Mahaboobi Jaleel, Sunil K. Panigrahi, Nirbhay Kumar Tiwari, Narasimha Rao Krishnamurthy, Taisuke Takahashi et al. · 2017 · Bioorganic & Medicinal Chemistry Letters
14. In vivo imaging reveals selective PPAR activity in the skin of peroxisome proliferator‐activated receptor responsive element‐luciferase reporter mice
    Noura El‐Jamal, Laurent Dubuquoy, Johan H. Auwerx, Benjamin Bertin, Pierre Desreumaux · 2012 · Experimental Dermatology
15. The Literature of Heterocyclic Chemistry, Part XIII, 2012–2013
    Leonid I. Belen’kii, Yu. B. Evdokimenkova · 2015 · Advances in heterocyclic chemistry
16. A new enantioselective synthesis of (S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid esters (EEHP and IEHP), useful pharmaceutical intermediates of PPAR agonists
    M. Mujahid, Sunita S. Kunte, Murugan Muthukrishnan · 2014 · Tetrahedron Letters
17. In Silico Design, Synthesis and Evaluation of Novel Series of Benzothiazole- Based Pyrazolidinediones as Potent Hypoglycemic Agents
    Michelyne Haroun · 2019 · Medicinal Chemistry
18. Design, synthesis, and biological evaluation of piperazine derivatives as pan-PPARs agonists for the treatment of liver fibrosis
    Gang Sun, Zhiqi Feng, Yufan Kuang, Zhuoxin Fu, Yanyan Wang, Xing Zhao, Fengqin Wang, Hongbin Sun, Haoliang Yuan, Liang Xiang Dai · 2024 · European Journal of Medicinal Chemistry
19. Structure-Based Design and Optimization Lead to the Identification of a Novel Potent sEH Inhibitor with PPARγ Partial Agonist Activity against Inflammatory and Metabolic-Related Diseases
    Ruolin Cao, Maoying Zhang, Minggang Qi, Zhen Zhang, Christophe H.P. Morisseau, Chunwei Zhou, Tianqi Sun, Junning Zhuang, Lu Chen, Cheng Xu et al. · 2025 · Journal of Medicinal Chemistry
20. Identification of novel farnesoid X receptor modulators using a combined ligand- and structure-based virtual screening
    Janosch Achenbach, Matthias Gabler, Ramona Steri, Manfred Schubert‐Zsilavecz, Ewgenij Proschak · 2013 · MedChemComm
21. Novel indole-2-carboxylic acid linked 3-phenyl-2-alkoxy propanoic acids: Synthesis, molecular docking and in vivo antidiabetic studies
    Amanjot Singh, Raman K. Verma, Anurag Kuhad, Rajiv Mall · 2017 · Medicinal Chemistry Research
22. Structure-based screening and biological validation of the anti-thrombotic drug-dicoumarol as a novel and potent PPARγ-modulating ligand
    Lei Ma, Junyuan Tang, Guihui Cai, Fangyuan Chen, Qingmei Liu, Zhi Zhou, Silin Zhang, Xiawen Liu, Ning Hou, Wei Yi · 2022 · Bioorganic Chemistry
23. Citrus nutraceutical eriocitrin and its metabolites are partial agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a molecular docking and molecular dynamics study
    Mahesha H. Gangadhariah, Triveni R. Pardhi, Jahnavi Ravilla, Subhash Chandra, Sridevi Annapurna Singh · 2022 · Journal of Biomolecular Structure and Dynamics
24. Structure–activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists
    Shogo Okazaki, Ryuta Shioi, Tomomi Noguchi‐Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi · 2016 · Bioorganic & Medicinal Chemistry
25. PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development
    Steven P. Tanis, Jerry R. Colca, Timothy T. Parker, Gerald D. Artman, Scott D. Larsen, William G. McDonald, Robert C. Gadwood, Rolf F. Kletzien, James B. Zeller, Pil H. Lee et al. · 2018 · Bioorganic & Medicinal Chemistry
26. A promising in silico protocol to develop novel PPARγ antagonists as potential anticancer agents: Design, synthesis and experimental validation via PPARγ protein activity and competitive binding assay
    Yuvaraj Sivamani, Dhivya Shanmugarajan, Thirumoorthy Durai Ananda Kumar, Syed Faizan, Bhavya Channappa, Namburu Lalitha Naishima, B. R. Prashantha Kumar · 2021 · Computational Biology and Chemistry
27. Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity
    Shogo Okazaki, Tomomi Noguchi‐Yachide, Taki Sakai, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi · 2016 · Bioorganic & Medicinal Chemistry
28. Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
    Mai S. El-Shoukrofy, Azza E. Ismail, Reem H. Elhamammy, Sherien A. Abdelhady, Rasha A. Nassra, Meenu Makkar, Mahmoud A. Agami, Ahmed M. Wahid, Hisham A. Nematalla, Minh Sai et al. · 2025 · European Journal of Medicinal Chemistry
29. The Effects of Omega-3 Supplementation Combined with Strength Training on Neuro-Biomarkers, Inflammatory and Antioxidant Responses, and the Lipid Profile in Physically Healthy Adults
    Sedat Okut, Murat Ozan, Yusuf Buzdağlı, Halil Uçar, Muhammet Raşit İnaç, Muhammet Talha Han, Esra Bayram, Nurcan Kılıç Baygutalp · 2025 · Nutrients
30. High-density lipoprotein-based drug discovery for treatment of atherosclerosis
    Yu Du, Li Wang, B. Hong · 2015 · Expert Opinion on Drug Discovery
31. Syntheses, biological evaluation of some novel substituted benzoic acid derivatives bearing hydrazone as linker
    Ganesh Prasad Mishra, Rajesh Sharma, Mukul Rameshchandra Jain, Debdutta Bandyopadhyay · 2021 · Research on Chemical Intermediates
32. Design, Synthesis, and Structure–Activity Relationships of Biaryl Anilines as Subtype-Selective PPAR-alpha Agonists
    Julia J. Lee, Ziwei Hu, Yuhong Anna Wang, Dinesh Nath, Wentao Liang, Yi Cui, Jian‐xing Ma, Adam S. Duerfeldt · 2023 · ACS Medicinal Chemistry Letters
33. Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists
    Aurélie Hurtevent, Morgan Le Naour, Véronique Leclerc, Pascal Carato, Patricia Melnyk, Nathalie Hennuyer, Bart Staels, Monique Beucher-Gaudin, Daniel‐Henri Caignard, Catherine Dacquet et al. · 2020 · Journal of Enzyme Inhibition and Medicinal Chemistry
34. The Loss of PPARγ Expression and Signaling Is a Key Feature of Cutaneous Actinic Disease and Squamous Cell Carcinoma: Association with Tumor Stromal Inflammation
    Raymond Lloyd Konger, Xiaoling Xuei, Ethel C Derr-Yellin, Fang Fang, Hongyu Gao, Yunlong Liu · 2024 · Cells
35. A New Selective PPARγ Modulator Inhibits Triglycerides Accumulation during Murine Adipocytes’ and Human Adipose-Derived Mesenchymal Stem Cells Differentiation
    Ghina Al Haj, Federica Rey, Toniella Giallongo, Mattia Colli, Barbara Marzani, Giammaria Giuliani, Alfredo Gorio, Gianvincenzo Zuccotti, Anna Maria Di Giulio, Stephana Carelli · 2020 · International Journal of Molecular Sciences
36. Structure-guided evolution of a 2-phenyl-4-carboxyquinoline chemotype into PPARα selective agonists: New leads for oculovascular conditions
    Xiao-Zheng Dou, Dinesh Nath, Younghwa Shin, Jian‐xing Ma, Adam S. Duerfeldt · 2018 · Bioorganic & Medicinal Chemistry Letters
37. Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies
    Jason D. Jacintho, Christopher S. Baccei, Yalda Bravo, Alex R. Broadhead, Austin C. Chen, Lucia D. Correa, Kim Fischer, Bryan A. Laffitte, Catherine A. A. Lee, Daniel S. Lorrain et al. · 2018 · Bioorganic & Medicinal Chemistry Letters
38. Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization
    Tsuyoshi Shinozuka, Tomoharu Tsukada, Kunihiko Fujii, Eri Tokumaru, Kousei Shimada, Yoshiyuki Onishi, Yumi Matsui, Satoko Wakimoto, Masanori Kuroha, Tsuneaki Ogata et al. · 2018 · Bioorganic & Medicinal Chemistry
39. GED-0507 is a novel potential antifibrotic treatment option for pulmonary fibrosis
    Silvia Speca, Caroline Dubuquoy, Christel Rousseaux, Philippe Chavatte, Pierre Desreumaux, Paolo Spagnolo · 2020 · Cellular and Molecular Immunology
40. Selective PPARγ Modulators for Type 2 Diabetes Treatment: How Far have We Come and What does the Future Hold?
    Antonio Lavecchia, Carmen Cerchia · 2018 · Future Medicinal Chemistry
41. Logistic role of carnitine shuttle system on radiation-induced L-carnitine and acylcarnitines alteration
    Hai-Xiang Liu, Qing-Jie Liu · 2022 · International Journal of Radiation Biology
42. Beyond PPARs and Metformin
    Philip A. Carpino, David Hepworth · 2012 · Annual reports in medicinal chemistry
43. A highly efficient and enantioselective synthesis of EEHP and EMHP: intermediates of PPAR agonists
    Mukesh Gangar, M. Harikrishnan, Sandeep Goyal, Maulik N. Mungalpara, Vipin A. Nair · 2016 · Tetrahedron Letters
44. Biotinylation enhances the anticancer effects of 15d‑PGJ2 against breast cancer cells
    Christelle Colin, Maxime Meyer, Claudia Cerella, Alexandra Kleinclauss, Gérald Monard, Michel Boisbrun, Marc F. Diederich, Stï¿ ⁄ phane Flament, Isabelle Grillier‐Vuissoz, Sandra Kuntz · 2018 · International Journal of Oncology
45. A new potent and selective peroxisome proliferator-activated receptor alpha partial agonist displays anti-steatotic effects In vitro and behaves as a safe hypolipidemic and hypoglycemic agent in a diabetic mouse model
    Antonio Laghezza, Emanuele Falbo, Federica Gilardi, Aurélien Thomas, Leonardo Brunetti, Rosalba Leuci, Luca Piemontese, Paolo Tortorella, Abanish Biswas, Ravi Pratap Singh et al. · 2025 · European Journal of Medicinal Chemistry
46. Multi-Target Glitazones for Modulating Peroxisome Proliferator-Activated Receptor-γ, Cyclooxygenase-2, and Carbonic Anhydrases for the Management of Metabolic Dysfunction.
    Perihan A. Elzahhar, Hisham A. Nematalla, Malak A. Abouayana, E. S. E. El Ashry, Mahmoud Balbaa, A. Petreni, Rasha A. Nassra, Hend A. Yassin, Yasmine N. Kamel, Mohamed A. Elrewiny et al. · 2025 · ACS Pharmacology & Translational Science
47. Synthesis and cytotoxicity studies of 1-propenyl-1,3-dihydro-benzimidazol-2-one
    Biswadip Banerji, Sumit Kumar Pramanik · 2015 · Journal of Chemical Biology
48. Design and synthesis of novel pyranone-based insulin sensitizers exhibiting in vivo hepatoprotective activity
    Atul Goel, Amrita Parihar, Pratibha Mishra, Salil Varshney, Pankaj Nag, Muheeb Beg, Anil Nilkanth Gaikwad, Srikanta Kumar Rath · 2013 · MedChemComm
49. Design and microwave facilitated green synthesis of 2-[4-(3-carboxymethyl, methoxy carbonylmethyl-2,4-dioxo and 4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-2 and 3-methyl propionic acid ethyl ester derivatives: a novel structural class of antidyslipidemic agents
    Ashok Kumar Singh, Avinash C. Tripathi, Aseem Tewari, Viney Chawla, Shailendra K. Saraf · 2017 · Medicinal Chemistry Research
50. Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists
    Ryuta Shioi, Shogo Okazaki, Tomomi Noguchi‐Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi · 2017 · Bioorganic & Medicinal Chemistry Letters
51. Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist
    Yan Shi, Jun Li, Lawrence J. Kennedy, Shiwei Tao, Andrés S. Hernández, Zhi Lai, Sean Chen, Henry Wong, Juliang Zhu, Ashok K. Trehan et al. · 2016 · ACS Medicinal Chemistry Letters
52. Design, synthesis, and biological evaluation of imidazolidinone derivatives as potent PPARα/δ agonists for the treatment of cholestatic liver diseases
    Zhuoxin Fu, Xin Liu, Wenhui Yu, Yufan Kuang, Fengqin Wang, Zhiqiang Qian, Qing‐Long Xu, Liang Xiang Dai, Zhiqi Feng · 2025 · European Journal of Medicinal Chemistry
53. Flavokawain B is an effective natural peroxisome proliferator-activated receptor γ-selective agonist with a strong glucose-lowering effect
    Qixin Wu, Yue Jiao, Jingzhe Li, Yanyan Ma, Jingyi Wang, Mingzhu Luo, Yiting Wang, Xinrong Fan, Changzhen Liu · 2024 · Biochemical Pharmacology
54. Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists
    Ayato Sato, Kosuke Dodo, Makoto Makishima, Yuichi Hashimoto, Mikiko Sodeoka · 2013 · Bioorganic & Medicinal Chemistry Letters
55. Design, synthesis, and evaluation of novel l-phenylglycine derivatives as potential PPARγ lead compounds
    Jinyu Liu, Xiaoyan Su, Huachong Li, Li Fan, Yuanyuan Li, Xuemei Tang, Ju-fang Yan, Xin Chen, Feifei Chen, Jie Liu et al. · 2018 · Bioorganic & Medicinal Chemistry
56. An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands
    Antonio Laghezza, Luca Piemontese, Paolo Tortorella, Fulvio Loiodice · 2019 · European Journal of Medicinal Chemistry
57. Multi-Strain Probiotic Lysate Attenuates TGF-β1-Induced Intestinal Fibrosis and EMT Modulating Smad, Akt, and WNT/β-Catenin Pathways
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58. Carbene insertion reactions for the construction of C C and C − heteroatom bonds using surface modified Silica microspheres as catalysts
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59. Pharmacological and Toxicological Advances in PPAR-Related Medicines
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60. Titanium-Promoted Acylation of Sulfonamides toN-Acylsulfonamide PPAR α Antagonists
    Alessandra Ammazzalorso, Maria Luisa Tricca, Isabella Bruno, Barbara De Filippis, Mauro Di Matteo, Marialuigia Fantacuzzi, Letizia Giampietro, Cristina Maccallini, Adriano Mollica, Rosa Amoroso · 2015 · Synthetic Communications
61. Crosstalk Between Signaling Stroke Cascade and Therapeutic Receptors PPAR-γ, ROCK, CB1R, and CB2R: From Mechanism to Therapies
    Mrugendra Bhojraj Potdar, Rohit P Bhamare, Yogeeta O. Agrawal, Aarti V. Belgamwar · 2025 · Translational Stroke Research
62. K 2 S 2 O 8 ‐Mediated Radical Cascade Alkylation/Cyclization of Ynones: Access to Oxoalkyl‐Substituted Indenones
    Si‐Wei Tian, Fang‐Ting Xiong, Biquan Xiong, Long‐Jin Zhong, Kewen Tang, Yu Liu · 2023 · ChemistrySelect
63. The PPAR System in Diabetes
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64. Recent advances in small molecule design strategies against hepatic fibrosis
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65. Natural products as ligands of peroxisome proliferator-activated receptor alpha for the inhibition of obesity and non-alcoholic fatty liver disease
    Jihang Hou, Pan Chen, Fang Chen, Jing Li, Zeyuan Deng, Ting F Luo · 2025 · Food Bioscience
66. Discovery of Potent Glucokinase and PPARγ Dual-Target Agonists through an Innovative Scheme for Regioselective Modification of Silybin
    Zhipeng Zhang, Yanqiu Meng, Zhan Wang, Yu Mei, Shite Gao, Yue-Jiao Wu, Shuxian Du · 2022 · ACS Omega
67. 4,5-diazafenylfluorene-rhodanine conjugates promote anoikis in A375 cells via inhibiting PPAR-γ expression
    Qiang Yin, Annoor Awadasseid, Yongnan Zhou, Ming Wang, Xuqiong Xiong, Yanling Wu, Wen Zhang · 2022 · Medicinal Chemistry Research
68. Design, synthesis and biological evaluation of cajanonic acid A analogues as potent PPAR γ antagonists
    Xiaoting Xu, Liying Shi, Yujuan Ban, Bi-Lan Luo, Gaofeng Zhu, Bing Guo, Lei Tang, Zhipei Sang, Jianta Wang · 2022 · Bioorganic & Medicinal Chemistry Letters
69. Design, synthesis and biological evaluation of truncated 1′-homologated 4′-selenonucleosides as PPARγ/δ dual modulators
    Hongseok Choi, Seungchan An, Young Eum Hyun, Minsoo Noh, Lak Shin Jeong · 2024 · Bioorganic Chemistry
70. Impact of ibuprofen on histomorphological indications of kidney in male albino rats
    Wurood Hasan Hadi, Ali Hassan Abood · 2023 · AIP conference proceedings
71. Flavonoids as Ligands for Peroxisome Proliferator-Activated Receptor γ
    Ayman Moawad Mahmoud · 2015 · International Journal of Food and Nutritional Science
72. Decades old glitazones still find niche in drug discoveries as PPAR-γ agonists: medicinal chemistry perspective, structure-activity relationships and therapeutic implications
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73. Design, Synthesis, and Biological Evaluation of Arylimidazole Derivatives as Potent PPARδ Agonists for the Treatment of Renal Fibrosis
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74. DESIGN, IN-SILICO DOCKING AND PREDICTIVE ADME PROPERTIES OF SOME THIAZOLIDINE-2, 4-DIONES DERIVATIVES AS PPARγ MODULATORS
    Sabina Yasmin, Venkatesan Jayaprakash · 2016 · International Journal of Pharmacy and Pharmaceutical Sciences
75. The PPAR System in Diabetes
    Jean-Claude Ansquer · 2023 · Contemporary diabetes
76. Synthesis and biological evaluation of cajanonic acid A derivatives as potential PPARγ antagonists
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77. Commentary on ‘Sebocyte differentiation as a new target for acne therapy: an in vivo experience’
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78. Estudos estruturais de novos ligantes sintéticos do receptor PPARY
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79. Cellular functional roles of celastrol on mitochondrial dysfunction-induced insulin resistance
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80. Drug Targets
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81. Measurement of Fatty Acid Oxidation in Mammalian Cells
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82. PPARγ regulates PNPLA3 in adipocytes in vitro and in vivo in healthy obese patients and mice with metabolic dysfunction-associated steatohepatitis
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83. Bi-functional cross-linking agent mediated label-free PPARγ immobilization and its application in bioactive compound screening from Huangqi Gegen decoction
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84. Chiglitazar/Carfloglitazar, a drug for the treatment of type 2 diabetes mellitus and more
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85. Discovery of Tetrazolone derivatives as potent PPARα/δ dual agonists for metabolic dysfunction-associated steatohepatitis
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86. Rôle du récepteur nucléaire PPARgamma dans les fonctions immuno-modulatrices de la cellule épithéliale intestinale au cours de la rectocolite hémorragique : contrôle de l’expression de l’isoforme courte de la TSLP
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87. Distinctive Behavior and Selective Modulation of PPARγ by Pentacyclic Triterpenoid Pomolic Acid and Hederagenin from Rosa canina
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88. Epidermal PPARγ Signaling as a Suppressor of Toll-like Receptor-Mediated Inflammation and Fibrosis: Relevance to Cutaneous Squamous Cell Carcinoma
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89. DTMB attenuates hepatic inflammation and lipid dysregulation via PPAR-γ modulation in diet-induced steatohepatitis
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90. Integrated bulk and single-cell transcriptomic analyses identify altered NK cell activation states and an ANXA1-associated wound-healing gene network in diabetic foot ulcer
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91. Structure–activity relationship (SAR) of polyphenols on molecular targets in diabetes
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92. Trends in Developing PPAR‐Gamma and FFAR1/GPCR40 Modulators for Managing Type‐II Diabetes Mellitus
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93. From pathophysiology to therapy: dual and triple agonists as a new frontier in metabolic dysfunction-associated steatotic liver disease
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94. BindingDB Entry 50007518: Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPARα/PPARγ Agonist Activity and Anti-inflammatory Effect.
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95. BindingDB Entry 50006895: Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects.
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96. BindingDB Entry 50018865: Design, Synthesis, and Structure-Activity Relationships of Biaryl Anilines as Subtype-Selective PPAR-alpha Agonists.
    BindingDB · 2024 · UC San Diego
97. BindingDB Entry 50042654: Discovery of INT131: a selective PPAR¿ modulator that enhances insulin sensitivity.
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98. BindingDB Entry 50044971: Structural development studies of PPARs ligands based on tyrosine scaffold.
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99. BindingDB Entry 50040910: Synthesis and structure-activity relationships of fibrate-based analogues inside PPARs.
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100. BindingDB Entry 50018564: Design, synthesis and biological evaluation of cajanonic acid A analogues as potent PPAR γ antagonists.
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