Targeting Peroxisome Proliferator-Activated Receptors (PPARs): Development of Modulators

Pirat, Céline, Farce, Amaury, Lebègue, Nicolas, Renault, Nicolas, Furman, Christophe, Millet, Régis, Yous, Saı̈d, Speca, Silvia +3 more·2012·Journal of Medicinal Chemistry
DOI 10.1021/jm101360s

Cited by (235)

Items 201–235 of 235

  1. BindingDB Entry 50011423: Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ).
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  2. BindingDB Entry 50046063: Peroxisome Proliferator-Activated Receptor¿ (PPAR¿) and Ligand Choreography: Newcomers Take the Stage.
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  3. BindingDB Entry 50040328: Fibrate-derived N-(methylsulfonyl)amides with antagonistic properties on PPARa.
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  4. BindingDB Entry 50000230: Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptorα/δ (PPARα/δ) dual agonists.
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  5. BindingDB Entry 50018768: Geminal Diheteroatomic Motifs: Some Applications of Acetals, Ketals, and Their Sulfur and Nitrogen Homologues in Medicinal Chemistry and Drug Design.
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  6. BindingDB Entry 50015403: Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPARγ Phosphorylation.
    BindingDB · 2023 · UC San Diego
  7. BindingDB Entry 50042642: The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.
    BindingDB · 2013 · UC San Diego
  8. BindingDB Entry 50008886: Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.
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  9. BindingDB Entry 50019730: Discovery of the First Subnanomolar PPARα/δ Dual Agonist for the Treatment of Cholestatic Liver Diseases.
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  10. BindingDB Entry 50006328: Design, Synthesis, and Biological Evaluation of Indole Biphenylcarboxylic Acids as PPARγ Antagonists.
    BindingDB · 2020 · UC San Diego
  11. BindingDB Entry 50001915: Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification.
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  12. BindingDB Entry 50047232: Synthesis, in vitro evaluation, and molecular modeling investigation of benzenesulfonimide peroxisome proliferator-activated receptorsa antagonists.
    BindingDB · 2017 · UC San Diego
  13. BindingDB Entry 50009075: An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands.
    BindingDB · 2021 · UC San Diego
  14. BindingDB Entry 50020905: Design, synthesis, and biological evaluation of piperazine derivatives as pan-PPARs agonists for the treatment of liver fibrosis.
    BindingDB · 2025 · UC San Diego
  15. BindingDB Entry 50009978: Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists.
    BindingDB · 2021 · UC San Diego
  16. BindingDB Entry 50003080: PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development.
    BindingDB · 2020 · UC San Diego
  17. BindingDB Entry 50047951: Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptora/d (PPARa/d) dual agonistic activity.
    BindingDB · 2018 · UC San Diego
  18. BindingDB Entry 50002749: Structure-guided evolution of a 2-phenyl-4-carboxyquinoline chemotype into PPARα selective agonists: New leads for oculovascular conditions.
    BindingDB · 2020 · UC San Diego
  19. BindingDB Entry 50002779: Design, synthesis, and evaluation of novel l-phenylglycine derivatives as potential PPARγ lead compounds.
    BindingDB · 2020 · UC San Diego
  20. BindingDB Entry 50040770: Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors.
    BindingDB · 2013 · UC San Diego
  21. BindingDB Entry 50007649: Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders.
    BindingDB · 2021 · UC San Diego
  22. BindingDB Entry 50023661: Design, synthesis, and biological evaluation of imidazolidinone derivatives as potent PPARα/δ agonists for the treatment of cholestatic liver diseases.
    BindingDB · 2026 · UC San Diego
  23. BindingDB Entry 50007285: Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies.
    BindingDB · 2021 · UC San Diego
  24. BindingDB Entry 50046385: Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological Evaluation.
    BindingDB · 2016 · UC San Diego
  25. BindingDB Entry 50001912: Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization.
    BindingDB · 2020 · UC San Diego
  26. BindingDB Entry 50047323: Pharmacophore elucidation of phosphoiodyn A - Potent and selective peroxisome proliferator-activated receptorß/d agonists with neuroprotective activity.
    BindingDB · 2017 · UC San Diego
  27. BindingDB Entry 50047003: Design, synthesis, and biological evaluation of novel thiazolidinediones as PPAR¿/FFAR1 dual agonists.
    BindingDB · 2017 · UC San Diego
  28. BindingDB Entry 50023579: Structure-Based Design and Optimization Lead to the Identification of a Novel Potent sEH Inhibitor with PPARγ Partial Agonist Activity against Inflammatory and Metabolic-Related Diseases.
    BindingDB · 2026 · UC San Diego
  29. BindingDB Entry 50007011: New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation.
    BindingDB · 2021 · UC San Diego
  30. BindingDB Entry 50002013: Novel highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulators with pharmacokinetic properties suitable for once-daily oral dosing.
    BindingDB · 2020 · UC San Diego
  31. BindingDB Entry 50040686: Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor¿.
    BindingDB · 2013 · UC San Diego
  32. BindingDB Entry 50015249: Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis.
    BindingDB · 2023 · UC San Diego
  33. BindingDB Entry 50002269: A novel structural class of coumarin-chalcone fibrates as PPARα/γ agonists with potent antioxidant activities: Design, synthesis, biological evaluation and molecular docking studies.
    BindingDB · 2020 · UC San Diego
  34. BindingDB Entry 50023569: A new potent and selective peroxisome proliferator-activated receptor alpha partial agonist displays anti-steatotic effects In vitro and behaves as a safe hypolipidemic and hypoglycemic agent in a diabetic mouse model.
    BindingDB · 2026 · UC San Diego
  35. BindingDB Entry 50047776: Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist.
    BindingDB · 2017 · UC San Diego