Discovery, Synthesis, and Biological Evaluation of Orally Active Pyrrolidone Derivatives as Novel Inhibitors of p53–MDM2 Protein–Protein Interaction

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8. Copper‐Catalyzed Ring‐Opening (3+2) Annulation of Cyclopropenones with Ketoxime Acetates: Access to 1,2‐Dihydro‐pyrrol‐3‐ones Bearing a Quaternary Carbon Center
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10. Discovery of Novel Drug-Conjugate Molecule ZM484 with Dual p53-MDM2 and TOP1 Inhibition for the Treatment of Colorectal Cancer
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12. Natural compounds as a basis for the design of modulators of p53 activity
    Maxim Gureev, Pavel B. Davidovich, Vyacheslav G. Tribulovich, Alexander V. Garabadzhiu · 2014 · Russian Chemical Bulletin
13. Pyrrolidinodiones in Enol-Ugi, Enol-Passerini, and Anomalous Enol-Passerini Condensations
    Ana G. Neo, Carlos F. Marcos · 2018 · International Electronic Conference on Synthetic Organic Chemistry (ECSOC)
14. Synthesis and Biological Evaluation of Some Pyrrolidine-2-one Derivatives
    Nadia Betti, Redha Ib. Hussain, Sahar Ab. Kadhem · 2020 · Al-Mustansiriyah Journal of Sciences
15. High-Throughput Screening in the Discovery of Small-Molecule Inhibitors of Protein-Protein Interactions
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16. Other Nonbiological Approaches to Targeted Cancer Chemotherapy
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17. PROTAC-Mediated Targeted Degradation of MDM2 Induces Tumor-Suppressive Signaling in Osteosarcoma Cells
    Yeongji Kim, J E Kim, Junwon Choi, Jinhyeong Kim, Soyeon Park, Wonji Choi, Hyun‐Ju An, Jinman Kim, Minsup Kim, Sujin Choi et al. · 2026 · Cells
18. New N-substituted 2,4,5-triarylimidazolines: synthesis and antitumor activity
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19. Research Progress on Small Molecule Inhibitors of MDM2-p53 Protein-protein Interaction
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20. Chemical library screening approaches to aid the design of protein–protein inhibitors
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23. Synthesis and Mechanism of p53‐MDM2 Inhibitors with Heterocyclic Structures: A Focused Review
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24. Sequential Double Modification of the Buta-1,3-Diene-1,1-Dicarbonitrile Fragment to Access 1,5-Dihydro-2h-Pyrrol-2-One Scaffold
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25. Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma
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26. Novel approach to the synthesis of 1,5-dihydro-2H-pyrrol-2-ones via sequential nucleophilic-electrophilic modification of pyrroles bearing a ylidenemalononitrile moiety
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27. One‐Pot, Solvent‐Free Construction of Polysubstituted Pyrrol‐2‐ones via α‐Keto Acid‐Arylamine‐DMAD Cascade C─C Coupling and Insights into LSD1 Enzyme Binding
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28. Photo-catalyzed decarboxylative annulation of N-substituted glycines with cyclopropenones: Synthesis of pyrrol-2-ones bearing quaternary centers
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29. Synthesis of 7a,8-Dihydrobenzo[5,6]chromeno[2,3-b]pyrrol-9(11H)-ones
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30. Navigating the p53‐MDM2 Landscape: Molecular Insights and Therapeutic Strategies
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31. Photocatalyzed Decarboxylative Annulation of N- Arylglycines with Cyclopropenones: Synthesis of Highly Functionalized Pyrrol-2-Ones
    L Chen, Qin Luo, Cen Jian, Sheng‐Jiao Yan · 2026 · The Journal of Organic Chemistry
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