On Dihydroorotate Dehydrogenases and Their Inhibitors and Uses
Munier-Lehmann, Hélène, Vidalain, Pierre-Olivier, Tangy, Frédéric, Janin, Yves L.·2013·Journal of Medicinal Chemistry
Cited by (236)
Items 101–200 of 236
- High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA VirusesMarianne Lucas‐Hourani, Hélène Munier‐Lehmann, Olivier Helynck, Anastassia V. Komarova, Philippe Desprès, Frédéric Tangy, Pierre‐Olivier Vidalain · 2014 · Journal of Visualized Experiments
- The mechanistic study of Leishmania major dihydro-orotate dehydrogenase based on steady- and pre-steady-state kinetic analysisRenata A.G. Reis, Patrícia Ferreira, Milagros Medina, Maria Cristina Nonato · 2015 · Biochemical Journal
- Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumanniiThomas A. Russo, Timothy C. Umland, Xiaoyi Deng, Farah El Mazouni, Sreekanth Kokkonda, Ruth Olson, Ulrike MacDonald, Janet M. Beanan, Cassandra L. Alvarado, Diana R. Tomchick et al. · 2022 · Proceedings of the National Academy of Sciences
- Evaluation of solvent and ion effects upon leflunomide adsorption characteristics on (6,0) zigzag single-walled carbon nanotube and immobilized dihydroorotate dehydrogenase activity: A computational DFT and experimental studyFariba Mollania, Heidar Raissi · 2017 · Journal of Molecular Liquids
- Global Metabolomics in Allogeneic Hematopoietic Cell Transplantation Recipients Discordant for Chronic Graft-versus-Host DiseaseDebra Lynch Kelly, Nosha Farhadfar, Angela Renee Starkweather, Timothy J. Garrett, Yingwei Yao, John R. Wingard, Iqbal Mahmud, Victoria S. Menzies, Param Patel, Karima M. Alabasi et al. · 2020 · Transplantation and Cellular Therapy
- Leflunomide: Traditional immunosuppressant with concurrent antiviral effectsKunyu Zheng, Yiran Chen, Suying Liu, Chengmei He, Yunjiao Yang, Di Wu, Li Wang, Mengtao Li, Xiaofeng Zeng, Fengchun Zhang · 2022 · International Journal of Rheumatic Diseases
- Compartmentalized cell envelope biosynthesis in Mycobacterium tuberculosisJúlia Puffal, Ian L. Sparks, James R. Brenner, Xuni Li, John Leszyk, Jennifer M. Hayashi, Scott A. Shaffer, Yasu S. Morita · 2025 · mBio
- Assessing risks of multiple sclerosis therapiesValeriy Parfenov, Myriam Schluep, Renaud Du Pasquier · 2013 · Journal of the Neurological Sciences
- An expert overview of emerging therapies for acute myeloid leukemia: novel small molecules targeting apoptosis, p53, transcriptional regulation and metabolismKapil Saxena, Marina Y Konopleva · 2020 · Expert Opinion on Investigational Drugs
- Structure-based design of potent human dihydroorotate dehydrogenase inhibitors as anticancer agentsWenlin Song, Shiliang Li, Yi Tong, Jiawei Wang, Lina Quan, Zhuo Chen, Zhenjiang Zhao, Yufang F. Xu, Lili Zhu, Xuhong H. Qian et al. · 2016 · MedChemComm
- Concise synthesis and antibacterial evaluation of novel 3‐(1,4‐disubstituted‐1,2,3‐triazolyl)uridine nucleosidesHamza Tachallait, Abdelhakim Bouyahya, Aicha Talha, Youssef Bakri, Nadia Dakka, Luc Demange, Rachid Benhida, Khalid Bougrin · 2018 · Archiv der Pharmazie
- A QM/MM Free Energy Study of the Oxidation Mechanism of Dihydroorotate Dehydrogenase (Class 1A) fromLactococcus lactisJosé Rogério A. Silva, Adrián E. Roitberg, Cláudio Nahum Alves · 2015 · The Journal of Physical Chemistry B
- Enabling desaturation of lactones by reversible catalytic activity of ‘ene’-reductasesFengxi Li, Yihang Dai, Shenhan Xie, Xiaoye Yu, Xinyan Shi, Zhengqiang Li, Chuang Du, Zhi Wang, Lei Wang · 2025 · Green Chemistry
- A carboxylic acid isostere screen of the DHODH inhibitor BrequinarLindsey G. DeRatt, E. Christine Pietsch, Alexandra Tanner, Paul L. Shaffer, Edgar Jacoby, Weixue Wang, Faraz Kazmi, Xiaochun Zhang, Ricardo M. Attar, James P. Edwards et al. · 2020 · Bioorganic & Medicinal Chemistry Letters
- Molecular Targets of Ascochlorin and Its Derivatives for Cancer TherapyJason Chua Min‐Wen, Benjamin Yan-Jiang Chua, Srishti Mishra, Xiaoyun Dai, Junji Magae, Ng Shyh‐Chang, Alan Prem Kumar, Gautam Sethi · 2017 · Advances in protein chemistry and structural biology
- Dihydroorotate Dehydrogenase as a Target for the Development of Novel Helicobacter pylori-Specific AntimicrobialsTomokazu Ohishi, D.K. Inaoka, Kiyoshi Kita, Manabu Kawada · 2018 · Chemical and Pharmaceutical Bulletin
- A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding modeTing Zeng, Zeping Zuo, Youfu Luo, Yinglan Zhao, Yamei Yu, Qiang Chen · 2019 · FEBS Open Bio
- Synthetic Retinoids as Potential Therapeutics in Prostate Cancer—An Update of the Last Decade of Research: A ReviewPrzemysław Hałubiec, Agnieszka Łazarczyk, Oskar Szafrański, Torsten Bohn, Joanna Dulińska-Litewka · 2021 · International Journal of Molecular Sciences
- Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell GrowthMakoto Kawatani, Harumi Aono, Takeshi Shimizu, Shouta Ohkura, Sayoko Hiranuma, Makoto Muroi, Naoko Ogawa, Tomokazu Ohishi, Shun‐ichi Ohba, Manabu Kawada et al. · 2021 · ACS Chemical Biology
- The Literature of Heterocyclic Chemistry, Part XIII, 2012–2013Leonid I. Belen’kii, Yu. B. Evdokimenkova · 2015 · Advances in heterocyclic chemistry
- Synthesis, structure–activity relationship and binding mode analysis of 4-thiazolidinone derivatives as novel inhibitors of human dihydroorotate dehydrogenaseFanxun Zeng, Tiantian Qi, Chunyan Li, Tingfang Li, Honglin Li, Shiliang Li, Lili Zhu, Xiaoyong Xu · 2017 · MedChemComm
- Design, synthesis, crystal structure andin vitrocytotoxic properties of a novel Schiff base derived from indole and biphenylFan-Zhi Bu, Xue-Jie Tan, Dian-Xiang Xing, Chao Wang · 2017 · Acta Crystallographica Section C Structural Chemistry
- Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy TreatmentChungen Li, Xiaowei Yang, Yuan Luo, Huan Liu, Xi Zoë Zhong, Xia Zhou, Ting Zeng, Lei Tao, Yue Zhou, Kun Gou et al. · 2021 · Journal of Medicinal Chemistry
- Novel fungicide quinofumelin shows selectivity for fungal dihydroorotate dehydrogenase over the corresponding human enzymeNorikazu Higashimura, Akira Hamada, Shinichi Banba · 2023 · Journal of Pesticide Science
- A novel series of teriflunomide derivatives as orally active inhibitors of human dihydroorotate dehydrogenase for the treatment of colorectal carcinomaChungen Li, Yue Zhou, Jing Xu, Xia Zhou, Zongkai Huang, Ting Zeng, Xiaowei Yang, Lei Tao, Kun Gou, Xi Zoë Zhong et al. · 2022 · European Journal of Medicinal Chemistry
- ML390 inhibits enterovirus 71 replication by targeting de novo pyrimidine biosynthesis pathwayQingyu Yang, Chengyuan Wu, Guangyan Zhu, Fuli Ren, Binbin Lin, Rui Huang, Xujuan Hu, Dingran Zhao, Ke Peng, Ying Wu et al. · 2022 · Antiviral Research
- Synthesis and Characterization of DHODH Inhibitors Based on the Vidofludimus Scaffold with Pronounced Anti‐SARS‐CoV‐2 ActivityChristian Gege, Friedrich Hahn, Christina Wangen, Sigrun Häge, Alexandra Herrmann, Nadja Uhlig, Valentina Eberlein, Leila Issmail, Robert Klopfleisch, Thomas Grünwald et al. · 2024 · ChemMedChem
- Low cytotoxic quinoline-4-carboxylic acids derived from vanillin precursors as potential human dihydroorotate dehydrogenase inhibitorsMilena M. Petrović, Cornelia Roschger, Sidrah Chaudary, Andreas F. Zierer, Milan P. Mladenović, Violeta R. Marković, Snežana S. Trifunović, Milan D. Joksović · 2021 · Bioorganic & Medicinal Chemistry Letters
- New Insights into the Interaction of Class II Dihydroorotate Dehydrogenases with Ubiquinone in Lipid Bilayers as a Function of Lipid CompositionJuan Manuel Orozco Rodriguez, Hanna Pauliina Wacklin, Luke A. Clifton, Oliver Bogojevic, Anna E. Leung, Giovanna Fragneto, Wolfgang Knecht · 2022 · International Journal of Molecular Sciences
- A Patent Review of Human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors as Anticancer Agents and their Other Therapeutic Applications (1999-2022)Pinky Gehlot, Vivek Kumar Vyas · 2023 · Recent Patents on Anti-Cancer Drug Discovery
- A high-throughput fluorescence-based assay for Plasmodium dihydroorotate dehydrogenase inhibitor screeningIván Caballero, María José Lafuente, Francisco‐Javier Gamo, Concepción Cid · 2016 · Analytical Biochemistry
- Classical swine fever virus non-structural protein 4A recruits dihydroorotate dehydrogenase to facilitate viral replicationBing-qian Zhao, Jing Chen, Jinxia Chen, Yan Fen Cheng, Jiang-fei Zhou, Ji-shan Bai, Ding-yi Mao, Bin Zhou · 2024 · Journal of Virology
- Activation de la réponse innée antivirale par des inhibiteurs de la biosynthèse des pyrimidinesPierre‐Olivier Vidalain, Marianne Lucas‐Hourani, Olivier Helynck, Frédéric Tangy, Hélène Munier‐Lehmann · 2015 · médecine/sciences
- Leflunomide triggers synthetic lethality in PTEN-deficient prostate cancerSait Ozturk, Deepti Mathur, Royce W. Zhou, David J. Mulholland, Ramon E. Parsons · 2020 · Prostate Cancer and Prostatic Diseases
- A novel and potent dihydroorotate dehydrogenase inhibitor suppresses the proliferation of colorectal cancer by inducing mitochondrial dysfunction and DNA damageXiaowei Yang, Chungen Li, Kun Gou, Xiaocong Liu, Yue Zhou, Jiao Zou, Qiang Chen, Youfu Luo, Yinglan Zhao · 2022 · MedComm – Oncology
- Crystal structures of FMN ‐bound and FMN ‐free forms of dihydroorotate dehydrogenase from Trypanosoma bruceiTomomi Kubota, Osamu Tani, Tomohiko Yamaguchi, Ichiji Namatame, Hitoshi Sakashita, Koji Furukawa, Kazuhiko Yamasaki · 2018 · FEBS Open Bio
- Discovery of potent human dihydroorotate dehydrogenase inhibitors based on a benzophenone scaffoldChungen Li, Yue Zhou, Jing Xu, Xia Zhou, Song Liu, Zongkai Huang, Zhiqiang Qiu, Ting Zeng, Kun Gou, Lei Tao et al. · 2022 · European Journal of Medicinal Chemistry
- Anti-Trypanosoma cruzi activity of Coptis rhizome extract and its constituentsYuki Tayama, Shusaku Mizukami, Kazufumi Toume, Katsuko Komatsu, Tetsuo Yanagi, Takeshi Nara, Thuan Minh Tieu, Nguyen Tien Huy, Shinjiro Hamano, Kenji Hirayama · 2023 · Tropical Medicine and Health
- Medicinal Chemistry Approaches for the Discovery of Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors as Antimalarial AgentsVivek Kumar Vyas, Tanvi Shukla, Manmohan Sharma · 2023 · Future Medicinal Chemistry
- Discovery and Optimization of Novel hDHODH Inhibitors for the Treatment of Inflammatory Bowel DiseaseXia Zhou, Kun Gou, Jing Xu, Lunan Jian, Yuan Luo, Chungen Li, Xinqi Guan, Jiahao Qiu, Jiao Zou, Yu Zhang et al. · 2023 · Journal of Medicinal Chemistry
- NK-A 17E-233I: a novel competitive inhibitor of human dihydroorotate dehydrogenase (DHODH) for cancer therapyMohammed Moustapha Anwar, Salvador Meseguer, Néstor García‐Rodríguez, Ewa Krupinska, Céleste Sèle, Aida Rodríguez-Jiménez, Suraj Verma, Samna Sagadevan, Javier Ramón, Ramón Martí et al. · 2025 · Journal of Experimental & Clinical Cancer Research
- On drug discovery against infectious diseases and academic medicinal chemistry contributionsYves Louis Janin · 2022 · Beilstein Journal of Organic Chemistry
- Dihydroorotate dehydrogenase as a herbicide targetStephen Oscar Duke · 2023 · Proceedings of the National Academy of Sciences
- Screening for DAX1 / EWS‐FLI1 functional inhibitors identified dihydroorotate dehydrogenase as a therapeutic target for Ewing's sarcomaMiwa Watanabe, Hiromichi Kosaka, Masamori Sugawara, Michihiro Maemoto, Yoko Ono, Takeshi Uemori, Ryota Shizu, Kouichi Yoshinari · 2023 · Cancer Medicine
- Evaluation of WO2013076170: the use of a dihydroorotate dehydrogenase inhibitor for the treatment of psoriasisPeter Norman · 2013 · Expert Opinion on Therapeutic Patents
- Synthesis, structure and antiproliferative and optical activities of two new biphenyl-derived Schiff basesXue-Jie Tan, Ling-Yao Zhang, Yuan-Kai Sun, Xue-Min Zhou · 2019 · Acta Crystallographica Section C Structural Chemistry
- Pivotal role of dihydroorotate dehydrogenase as a therapeutic target in adult T‐cell leukemiaChie Ishikawa, Naoki Mori · 2024 · European Journal Of Haematology
- Drug Design Strategies, Modes of Action, Synthesis and Industrial Challenges Behind Trifluoromethylated New Chemical EntitiesLeitao EPT, Sobral LMS · 2024 · Journal of Biomedical Research & Environmental Sciences
- Ene‐Reductase‐Catalyzed Aromatization of Simple Cyclohexanones to PhenolsJie Chen, Shaofang Qi, Zhiguo Wang, Liran Hu, Jialing Liu, Guixiang Huang, Yongzhen Peng, Zheng Dong Fang, Qi Wu, Yujing Hu et al. · 2024 · Angewandte Chemie
- Intrinsic Natural Resistance of Various Plant Pathogens to Ipflufenoquin, a New DHODH (Dihydroorotate Dehydrogenase)-Inhibiting Fungicide, in Relation to an Unaltered Amino Acid Sequence of the Target SiteHideo Ishii, Izumi Okane, Yuichi Yamaoka · 2024 · Plant Disease
- Accelerating drug discovery targeting dihydroorotate dehydrogenase using machine learning and generative AI approachesGayathri Krishnamurthy Ganga · 2025 · Computational Biology and Chemistry
- In silico Molecular Docking Analysis of Three Molecules Isolated from Litsea guatemalensis Mez on Anti-inflammatory ReceptorsLucrecia Peralta, Allan Vásquez, Nereida Marroquín, Lesbia Guerra, Sully Margot Cruz, Armando Cáceres · 2023 · Combinatorial Chemistry & High Throughput Screening
- Medicinal Chemistry Case History: Discovery of the Dihydroorate Dehydrogenase Inhibitor DSM265 as an Antimalarial Drug CandidateMargaret A. Phillips, Pradipsinh K. Rathod, Thomas Rueckle, D. Matthews, Jeremy Nicholas Burrows, Susan A. Charman · 2016 · Elsevier eBooks
- Sequence Similarity Network Guided Discovery of a Dehydrogenase for Asymmetric Carbonyl DehydrogenationYujing Hu, Jie Chen, Shaofang Qi, Hui Wang, Zhaoxuan Zhu, Yongzhen Peng, Wenjing Wang, Guixiang Huang, Zheng Dong Fang, Yuxuan Ye et al. · 2025 · Angewandte Chemie
- Phenotypical Screening of an MMV Open Box Library and Identification of Compounds with Antiviral Activity against St. Louis Encephalitis VirusGiuliana Eboli Sotorilli, Humberto Doriguêtto Gravina, Ana Carolina de Carvalho, Jacqueline Farinha Shimizu, Marina Alves Fontoura, Talita Diniz Melo‐Hanchuk, Artur T. Cordeiro, Rafael Elias Marques · 2023 · Viruses
- Crystal structure of dihydroorotate dehydrogenase from Helicobacter pylori with bound flavin mononucleotideAshna A. Agarwal, John D. Georgiades, David M. Dranow, Donald D. Lorimer, Thomas E. Edwards, Kayleigh F. Barrett, Justin K. Craig, Wesley C. Van Voorhis A, Peter John Myler, Craig L. Smith · 2025 · Acta Crystallographica Section F Structural Biology Communications
- Management of disease-modifying therapies in multiple sclerosis and comorbid rheumatoid arthritisFranz Felix Konen, Torsten Witte, Diana Ernst, David Hagin, Konstantin Fritz Jendretzky, Nora Möhn, Sandra Nay, Lea Martha Grote-Levi, Kurt‐Wolfram Sühs, Luisa Klotz et al. · 2025 · Neurological Research and Practice
- N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitorsChahrazed Bouzriba, Lauriane Larcher, Mathieu Gagné‐Boulet, Sébastien Fortin · 2020 · Bioorganic & Medicinal Chemistry
- Lifting the Differentiation EmbargoAnne‐Louise Latif, Tessa L. Holyoake · 2016 · Cell
- Antimalarial drugsBenjamin J. Sawyer, Md Imdadul H. Khan, Hoang V. Le · 2023 · Elsevier eBooks
- Tiratricol, a thyroid hormone metabolite, has potent inhibitory activity against human dihydroorotate dehydrogenaseShuying Cao, Hui Ma, Zhaomin Xu, Wenqing Fang, Jin Yan Huang, Ying Huang · 2023 · Chemical Biology & Drug Design
- QSAR and molecular docking studies on 4-quinoline carboxylic acid derivatives as inhibition of vesicular stomatitis virus replicationTawassl Tajelsir Hassan Hajalsiddig, A. E. M. Saeed · 2019 · European Journal of Chemistry
- Structural Optimization and Structure–Activity Relationship of 4-Thiazolidinone Derivatives as Novel Inhibitors of Human Dihydroorotate DehydrogenaseFanxun Zeng, Lina Quan, Guantian Yang, Tiantian Qi, Letian Zhang, Shiliang Li, Honglin Li, Lili Zhu, Xiaoyong Xu · 2019 · Molecules
- Chemical Constituents from Chloranthus elatior and Their Inhibitory Effect on Human Dihydroorotate DehydrogenaseQian Yang, An Jia, Xizi Liu, Shiyi Han, Siyang Fan · 2021 · Planta Medica
- Synthesis of Potential Inhibitors Targeting Dihydroorotate Dehydrogenase as Herbicide CandidatesWenfei Wang, Lijia Di, Luyang Tian, Jingqian Huo, Zexiu An, Jinlin Zhang, Lai Chen · 2025 · Journal of Agricultural and Food Chemistry
- Exploring quinone‐binding sites as targets for pesticidesShinichi Banba · 2025 · Pest Management Science
- Development of a machine learning‐based target‐specific scoring function for structure‐based binding affinity prediction for human dihydroorotate dehydrogenase inhibitorsJinhui Meng, Li Zhang, Zhe He, Mengfeng Hu, Jinhan Liu, Wenzhuo Bao, Qifeng Tian, Huawei Feng, Hongsheng Liu · 2024 · Journal of Computational Chemistry
- Development of a biomarker to monitor target engagement after treatment with dihydroorotate dehydrogenase inhibitorsMichael A. Pontikos, Christopher Leija, Zhiyu Zhao, Xiaoyu Wang, Jessica A. Kilgore, Belen M. Tornesi, Nicole Adenmatten, Margaret A. Phillips, Noelle Sevilir Williams · 2022 · Biochemical Pharmacology
- Small-Molecule Strategies against Human Adenoviruses: Progress, Challenges, and Future PerspectivesJingwen Huo, Haiying Chen, Xinhui Qiu, Ge Wang, Javier Sánchez‐Céspedes, Kuancheng Liu, Jia Zhou, Jimin Xu · 2025 · Journal of Medicinal Chemistry
- Inhibitors of pyrimidine synthesis synergize with N4-hydroxycytidine to diminish influenza virus replicationLeon Schrell, David Scheibner, Antje Dickmanns, Kim M. Stegmann, Lukas Mathias Michaely, Annika Graaf-Rau, Philip A. Beer, Andrew Parker, Sandra Diederich, Anne Balkema‐Buschmann et al. · 2025 · Antiviral Research
- Lapachol, a dihydroorotate dehydrogenase inhibitor, demonstrates antiviral activity against feline calicivirus in vitro and in vivoZexin Liu, Guohong Albert Wu, Jianwei Mao, Yutong Zheng, Qizhen Fu, Sifan Lin, Y L CHEN, Weisan Chen, Pei Zhou, Jianxin Chen · 2026 · Antiviral Research
- Antiviral activities of ascofuranone and naphthoquinone derivatives against Ebola virusChristelle M. Pemba, Yasuteru Sakurai, Yohei Kurosaki, J. J. Patten, Eri Amalia, D.K. Inaoka, Robert A. Davey, T. Shiba, Kiyoshi Kita, Jiro Yasuda · 2026 · Antiviral Research
- Contribution of dihydroorotate dehydrogenase complex to NADH supply and metabolic flux redirection in Clostridium acetobutylicumDandan Jiang, Jihong Yi, Haifeng Zhu, Liangliang Gao, Shuning Wang, Guodong Liu, 李澜鹏, Quan Zhang, MENG WANG, Armin Ehrenreich et al. · 2026 · Bioresource Technology
- A ferredoxin-dependent dihydropyrimidine dehydrogenase in Clostridium chromiireducensFeifei Wang, Yifeng Wei, Qiang Lü, Ee Lui Ang, Huimin Zhao, Yan Zhang · 2020 · Bioscience Reports
- Photochemical Desaturation and Epoxidation with Oxygen by Sequential Flavin CatalysisAlexandra Walter, Wolfgang Eisenreich, Golo Storch · 2023 · Angewandte Chemie
- Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery MethodsWilliam T. Higgins, Sandip M. Vibhute, Chad E. Bennett, Steffen Lindert · 2024 · Journal of Chemical Information and Modeling
- IPP/CNRS-A017: A chemical probe for human dihydroorotate dehydrogenase (hDHODH)Andreas Krämer, Amelie Tjaden, Benardina Ndreshkjana, Claudia Tredup, Henner F. Farin, Stefan Knapp, Yves Louis Janin, Susanne Müller · 2022 · Current Research in Chemical Biology
- Biological evaluation of quinoline derivatives as inhibitors of human dihydroorotate dehydrogenaseJiawei Wang, Yanyan Diao, Junsheng Zhu, Shiliang Li, Zhenjiang Zhao, Honglin Li, Lili Zhu · 2016 · MedChemComm
- Evaluation of Cardiospermum halicacabum leaf compounds against human DihydroOrotate Dehydrogenase: a target for Rheumatoid Arthritis using Structure based Drug DesigningPriya Swaminathan, Lilly M. Saleena · 2017 · Journal of Applied Pharmaceutical Science
- A Bioinformatics Analysis and Homology 3D Modeling of Dihydroxy-orotate-dehydrogenase of Plasmodium ovaleRudi Nirwantono, Khoirunnisa Assidqi, Alam Ahmad Hidayat, Joko Pebrianto Trinugroho, Bens Pardamean · 2023 · International Conference on Informatics, Multimedia, Cyber and Information System (ICIMCIS)
- Síntese de inibidores das enzimas cruzaína e diidroorotato desidrogenase de Trypanosoma cruziLeandro A. Alves Avelar · 2014
- Identifizierung und Charakterisierung der Dihydroorotat Dehydrogenase als Zielstruktur von 1-Hydroxyquinolonen in Toxoplasma gondiiJana Hegewald · 2014
- Desenvolvimento de uma plataforma modelo para a busca de ligantes com potencial leishmanicida baseado na inibição seletiva da enzima diidroorotato desidrogenaseEder Júnior Lorenzato · 2016
- Determinação do modo de interação de inibidores reversíveis da cruzaína de Trypanosoma cruzi via cristalografia de raios XW.B. Fernandes · 2015
- Synthesis of novel PfDHODH inhibitors based on 4-aminocoumarin structuresFederico Valerio · 2016 · Lund University Publications Student Papers (Lund University)
- E-pharmacophore screening and induced fit docking of phytocompounds against human dihydroorotate dehydrogenasePriya Swaminathan · 2017 · International Journal of Pharma and Bio Sciences
- Triagem de inibidores da enzima DHODH de Leishmania major em Asteraceae: estudos metabolômicos e da relação estrutura-atividade quantitativa (QSAR)Lucas Apolinário Chibli · 2018
- Reposicionamento de drogas antimaláricas no tratamento da esquistossomose baseado na inibição seletiva da enzima diidroorotato desidrogenaseFelipe A. Calil · 2019
- Reposicionamento de fármacos para o tratamento da doença de Chagas: desenvolvimento de modelos computacionais baseados em ligantes ativos fenotipicamente contra o Trypanosoma cruzi e na inibição da diidroorotato desidrogMarcos Antonio Ferreira · 2021 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Analysis of teriflunomide therapy on EAEDannheim Jasemin · 2022
- Exploring Phytophthora agathidicida Oospore Viability and GerminationFairhurst, Michael · 2023
- Desenvolvimento de um ensaio fenotípico para triagem de alta performance de compostos protetores contra a infecção pelo vírus da encefalite de St. LouisGiuliana Eboli Sotorilli · 2022
- PENDEKATAN KOMPUTASI UNTUK MENGATASI MALARIA DARI Coscinium fenestratumUniversitas Lambung Mangkurat, Samsul Hadi, Kunti Nastiti, Prodi S1 Farmasi, Fakultas Kesehatan, Universitas Sari Mulia · 2023 · Jurnal Insan Farmasi Indonesia
- Additional file 1 of Anti-Trypanosoma cruzi activity of Coptis rhizome extract and its constituentsYuki Tayama, Shusaku Mizukami, Kazufumi Toume, Katsuko Komatsu, Tetsuo Yanagi, Takeshi Nara, Paul Tieu, Huy, Nguyen Tien, Hamano, Shinjiro, Hirayama, Kenji · 2023 · Figshare
- Design, Construction, and Efficacy of a Novel Multiepitope Chimeric Vaccine Against Lumpfish (Cyclopterus lumpus) InfectionJoy Chukwu-Osazuwa, Trung Cao, Ignacio Vásquez, Hajarooba Gnanagobal, Ahmed Hossain, Oluwatoyin Onireti, Setu Chakraborty, Vimbai Irene Machimbirike, Javier Santander · 2026 · Fishes
- In silico Optimization of Dihydroorotate dehydrogenase Inhibitors for Malaria viaDocking, Molecular Dynamics, and ADMET EvaluationSimon Mugisa, Lalitha Bhaskarini Dyvapu, Tuyizere Rebecca, Uwase Shema Christelle, Hekmatullah Nang, Dora Mallikharjuna Sarma Mamillapalli, Narayana Murthy Ganta, Naresh Dumala, Manikanta Murahari · 2026 · Discover Molecules
- Multiple Sklerose und rheumatoide Arthritis: Überschneidungen und Interferenzen bei den TherapiekonzeptenFranz Felix Konen, Torsten Witte, Marc Pawlitzki, Sven G. Meuth, Thomas Skripuletz · 2026 · Deutsches Ärzteblatt
- Nucleic acid metabolism as therapeutic target in cancer: a comprehensive analysis of folate cycle, nucleotide synthesis, and clinical applicationsJacinta DSouza, Harish Kundaikar · 2026 · Elsevier eBooks
- Manipulation of nucleotides by the obligate intracellular bacterium Chlamydia trachomatisLaure Blanchet · 2024
- Dihydroorotate dehydrogenase: A multifunctional target in cancer, infectious diseases, and immune disordersXiaoying Guan, Jinchun Li, Xiaoli Guan, Cuirong Hao, Yajie Zhang, Hong Yan · 2026 · The International Journal of Biochemistry & Cell Biology