On Dihydroorotate Dehydrogenases and Their Inhibitors and Uses
Munier-Lehmann, Hélène, Vidalain, Pierre-Olivier, Tangy, Frédéric, Janin, Yves L.·2013·Journal of Medicinal Chemistry
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- BindingDB Entry 50046110: Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).BindingDB · 2016 · UC San Diego
- BindingDB Entry 50015235: Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50008881: Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50011617: Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50020851: Discovery and Optimization of NovelBindingDB · 2024 · UC San Diego
- BindingDB Entry 50012083: A carboxylic acid isostere screen of the DHODH inhibitor Brequinar.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50049169: Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.BindingDB · 2019 · UC San Diego
- BindingDB Entry 50009286: Dihydroorotate dehydrogenase inhibitors in anti-infective drug research.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50015476: Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50044463: Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.BindingDB · 2015 · UC San Diego
- BindingDB Entry 50012657: N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50014419: Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50045625: Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase.BindingDB · 2016 · UC San Diego
- BindingDB Entry 50003041: Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase.BindingDB · 2020 · UC San Diego
- BindingDB Entry 50010583: Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50048029: Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.BindingDB · 2018 · UC San Diego
- BindingDB Entry 50043446: TBABindingDB · 2014 · UC San Diego
- BindingDB Entry 50045613: Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).BindingDB · 2016 · UC San Diego
- BindingDB Entry 50003270: Lead-like Drugs: A Perspective.BindingDB · 2020 · UC San Diego
- BindingDB Entry 50011749: Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50046135: Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH.BindingDB · 2016 · UC San Diego
- BindingDB Entry 50019934: Discovery of potent human dihydroorotate dehydrogenase inhibitors based on a benzophenone scaffold.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50048288: Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase.BindingDB · 2018 · UC San Diego
- BindingDB Entry 50001475: Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors.BindingDB · 2020 · UC San Diego
- BindingDB Entry 50002707: Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.BindingDB · 2020 · UC San Diego
- BindingDB Entry 50016907: A novel series of teriflunomide derivatives as orally active inhibitors of human dihydroorotate dehydrogenase for the treatment of colorectal carcinoma.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50010748: Bifunctional Naphtho[2,3-BindingDB · 2021 · UC San Diego