Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain

Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells

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Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase

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Inhibition of HIV-1 Ribonuclease H by a Novel Diketo Acid, 4-[5-(Benzoylamino)thien-2-yl]-2,4-dioxobutanoic Acid

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Raltegravir: The first HIV integrase inhibitor

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6-[1-(4-Fluorophenyl)methyl-1H-pyrrol-2-yl)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the ribonuclease H activity in vitro

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Design, Synthesis, and Biological Evaluation of a Series of 2-Hydroxyisoquinoline-1,3(2 H ,4 H )-diones as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and the Reverse Transcriptase RNase H Domain

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Structural insights into the retroviral DNA integration apparatus

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HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions

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Flavocoxid, a dual inhibitor of cyclooxygenase and 5‐lipoxygenase, blunts pro‐inflammatory phenotype activation in endotoxin‐stimulated macrophages

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From Ligand to Complexes: Inhibition of Human Immunodeficiency Virus Type 1 Integrase by β-Diketo Acid Metal Complexes

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Dual inhibition of monoamine oxidase B and antagonism of the adenosine A2A receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues

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Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase, RNase H, and Integrase Activities by Hydroxytropolones

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Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives

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HIV-1 reverse transcriptase inhibition by a dipyridodiazepinone derivative: BI-RG-587

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HIV-1 RT-Associated RNase H Function Inhibitors: Recent Advances in Drug Development

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A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5, 1- jk][1,4]benzodiazepin-2(1H)-thione (TIBO R82150).

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Emerging trends in metalloprotein inhibition

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Viral enzymes containing magnesium: Metal binding as a successful strategy in drug design

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Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach

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2-Hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: Influence of the alkylation of position 4

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6-(1-Benzyl-1 H -pyrrol-2-yl)-2,4-dioxo-5-hexenoic Acids as Dual Inhibitors of Recombinant HIV-1 Integrase and Ribonuclease H, Synthesized by a Parallel Synthesis Approach

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Preferential Inhibition of the Magnesium-Dependent Strand Transfer Reaction of HIV-1 Integrase by α-Hydroxytropolones

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Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase

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Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H

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Dual inhibition: a novel promising pharmacological approach for different disease conditions

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Computer-assisted rational design, synthesis, and bioassay of non-steroidal anti-inflammatory agents

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Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1 H -isoindole Derivatives, Inhibitors of HIV-1 Integrase

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Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity

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Inhibition of HIV-1 Ribonuclease H Activity by Novel Frangula-Emodine Derivatives

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Design, synthesis and biological evaluation of heteroaryl diketohexenoic and diketobutanoic acids as HIV-1 integrase inhibitors endowed with antiretroviral activity

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Madurahydroxylactone Derivatives as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and RNase H

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Alizarine derivatives as new dual inhibitors of the HIV‐1 reverse transcriptase‐associated DNA polymerase and RNase H activities effective also on the RNase H activity of non‐nucleoside resistant reverse transcriptases

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WJD008, a Dual Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin Inhibitor, Prevents PI3K Signaling and Inhibits the Proliferation of Transformed Cells with Oncogenic PI3K Mutant

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Dual Inhibition of Human Rhinovirus 2A and 3C Proteases by Homophthalimides

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HIV-1 RNase H: Recent Progress in an Exciting, yet Little Explored, Drug Target

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Synthesis and SAR of 4-Aryl-2-hydroxy-4-oxobut-2-enoic Acids and Esters and 2-Amino-4-aryl-4-oxobut-2-enoic Acids and Esters: Potent Inhibitors of Kynurenine-3-hydroxylase as Potential Neuroprotective Agents

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New Anthraquinone Derivatives as Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Function

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Metal chelators as antiviral agents.

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Diketoacid Inhibitors of HIV-1 Integrase: From L-708,906 to Raltegravir and Beyond

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Effects of New Quinizarin Derivatives on Both HCV NS5B RNA Polymerase and HIV-1 Reverse Transcriptase Associated Ribonuclease H Activities

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Synthesis of substituted hexa-3,5-dienoic acid methyl esters from conjugated dienones

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2-(Arylamino)-6-(trifluoromethyl)nicotinic acid derivatives: new HIV-1 RT dual inhibitors active on viral replication

Corona, A., Onnis, V., Del Vecchio, C., Esposito, F., Cheng, Y.-C., & Tramontano, E. (2020) · Molecules · doi:10.3390/molecules25061338 · Cited by 19 · see citing works

Retroviral RNase H: structure, mechanism, and inhibition

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Flavonoids and Acid-Hydrolysis derivatives of <i>Neo</i> -Clerodane diterpenes from <i>Teucrium flavum</i> subsp. <i>glaucum</i> as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function

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Ribonuclease PH interacts with an acidic ribonuclease E site through a basic 80-amino acid domain

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Acetylation regulates the oligomerization state and activity of RNase J, the Helicobacter pylori major ribonuclease

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A Structural Analysis of Ribonuclease P

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Mutational Analysis of the Nuclease Domain of Escherichia coli Ribonuclease III. Identification of Conserved Acidic Residues that Are Important for Catalytic Function in Vitro

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A tale of two mRNA degradation pathways mediated by RNase E

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