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The Many Roles for Fluorine in Medicinal Chemistry

Hagmann, William K.·2008·Journal of Medicinal Chemistry
DOI 10.1021/jm800219f
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Abstract

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTThe Many Roles for Fluorine in Medicinal ChemistryWilliam K. Hagmann†View Author Information Merck Research Laboratories, Rahway, New Jersey 07065† Contact information: phone, 732-594-7249; fax, 732-594-5966; e-mail, [email protected]Cite this: J. Med. Chem. 2008, 51, 15, 4359–4369Publication Date (Web):June 21, 2008Publication History Received29 February 2008Published online21 June 2008Published inissue 1 August 2008https://pubs.acs.org/doi/10.1021/jm800219fhttps://doi.org/10.1021/jm800219freview-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views33030Altmetric-Citations2988LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with…

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Research works printed but not linked: 82

  1. Müller K., 2004, ChemBioChem, 5, 559, 10.1002/cbic.200400071 · DOI
  2. Bohm H.-J., 2004, ChemBioChem, 5, 637, 10.1002/cbic.200301023 · DOI
  3. Kirk K. L., 2006, Curr. Top. Med. Chem., 6, 1445, 10.2174/156802606777951118 · DOI
  4. Kirk K. L., 2006, J. Fluorine Chem., 127, 1013, 10.1016/j.jfluchem.2006.06.007 · DOI
  5. Fried J., 1953, J. Am. Chem. Soc., 75, 2273, 10.1021/ja01105a527 · DOI
  6. Heidelburger C., 1957, Nature, 179, 663, 10.1038/179663a0 · DOI · Paper page
  7. 2007, MDL Drug Data Report (MDDR)
  8. Markovski L. N., 1973, Synthesis, 787, 10.1055/s-1973-22302 · DOI
  9. Middleton W. J., 1975, J. Org. Chem., 40, 574, 10.1021/jo00893a007 · DOI
  10. Bondi A., 1964, J. Phys. Chem., 68, 441, 10.1021/j100785a001 · DOI
  11. Schlosser M., 1996, Tetrahedron, 52, 99, 10.1016/0040-4020(95)00886-D · DOI
  12. Mikami K., 2004, Chem. Rev., 104, 1, 10.1021/cr030685w · DOI
  13. Wolf C., 1995, Liebigs Ann., 781, 10.1002/jlac.1995199505114 · DOI
  14. Leroux F., 2004, ChemBioChem, 5, 644, 10.1002/cbic.200300906 · DOI
  15. Zanda M., 2004, New J. Chem., 28, 1401, 10.1039/b405955g · DOI
  16. Molteni M., 2004, J. Fluorine Chem., 125, 1735, 10.1016/j.jfluchem.2004.09.014 · DOI
  17. Morgenthaler M., 2007, ChemMedChem, 2, 1100, 10.1002/cmdc.200700059 · DOI
  18. Dean J. A., 1999, Lange’s Handbook of Chemistry
  19. Brown H. C., 1955, Determination of Organic Structures by Physical Methods
  20. Doan K. M. M., 2002, J. Pharmacol. Exp. Ther., 303, 1029, 10.1124/jpet.102.039255 · DOI
  21. Sun S., 2006, Curr. Top. Med. Chem., 6, 1457, 10.2174/156802606777951046 · DOI
  22. Müller K., 2007, Science, 317, 1881, 10.1126/science.1131943 · DOI
  23. DiMagno S. G., 2006, Curr. Top. Med. Chem., 6, 1473, 10.2174/156802606777951127 · DOI
  24. Smart B. E., 1994, Organofluorine Chemistry, Principles and Commercial Applications, 57, 10.1007/978-1-4899-1202-2_3 · DOI
  25. Borodine A., 1863, Justus Liebigs Ann. Chem., 126, 58, 10.1002/jlac.18631260105 · DOI
  26. Swarts F., 1892, Bull. Acad. R. Belg., 24, 309
  27. Hudlicky M., 1995, Chemistry of Organic Fluorine Compounds II: A Critical Review
  28. Uneyam K., 2006, Organofluorine Chemistry, 10.1002/9780470988589 · DOI
  29. Wilkinson J. A., 1992, Chem. Rev., 92, 505, 10.1021/cr00012a002 · DOI
  30. Shimizu M., 2005, Angew. Chem., Int. Ed., 44, 214, 10.1002/anie.200460441 · DOI
  31. Hudlicky M., 1988, Org. React. (N.Y.), 515, 35
  32. Camps F., 1989, J. Org. Chem., 54, 4294, 10.1021/jo00279a013 · DOI
  33. Furuta S., 1999, Bull. Chem. Soc. Jpn., 72, 805, 10.1246/bcsj.72.805 · DOI
  34. Rozen S., 2005, Acc. Chem. Res., 38, 803, 10.1021/ar040270c · DOI
  35. Resnati G., 1991, J. Org. Chem., 56, 4925, 10.1021/jo00016a022 · DOI
  36. Lal G. S., 1996, Chem. Rev., 96, 1737, 10.1021/cr941145p · DOI
  37. Hodson H. F., 1994, Tetrahedron, 50, 1899, 10.1016/S0040-4020(01)80862-0 · DOI
  38. Singh R. P., 2004, Acc. Chem. Res., 37, 31, 10.1021/ar030043v · DOI
  39. Caldwell C. G., 2004, Bioorg. Med. Chem. Lett., 14, 1265, 10.1016/j.bmcl.2003.12.040 · DOI
  40. Ma J.-A., 2004, Chem. Rev., 104, 6119, 10.1021/cr030143e · DOI
  41. Davis F. A., 1992, Tetrahedron Lett., 33, 1153, 10.1016/S0040-4039(00)91883-5 · DOI
  42. Takeuchi Y., 1999, J. Org. Chem., 64, 5708, 10.1021/jo9904011 · DOI
  43. Cahard D., 2000, Org. Lett., 2, 3699, 10.1021/ol006610l · DOI
  44. Shibata N., 2000, J. Am. Chem. Soc., 122, 10728, 10.1021/ja002732x · DOI
  45. Togni A., 2001, Chimia, 55, 801, 10.2533/chimia.2001.801 · DOI
  46. Frantz R., 2003, Org. Lett., 5, 1709, 10.1021/ol0343459 · DOI
  47. Beeson T. D., 2005, J. Am. Chem. Soc., 127, 8826, 10.1021/ja051805f · DOI
  48. Prakash G. K. S., 1997, Chem. Rev., 97, 757, 10.1021/cr9408991 · DOI
  49. Kitazume T., 1982, Chem. Lett., 137, 10.1246/cl.1982.137 · DOI
  50. Chen Q.-Y., 1989, J. Chem. Soc., Chem. Commun., 705, 10.1039/c39890000705 · DOI
  51. Zhang X., 2000, J. Org. Chem., 65, 7075, 10.1021/jo005520r · DOI
  52. Veliz E. A., 2001, Org. Lett., 3, 2969, 10.1021/ol016295i · DOI
  53. Walter M. W., 1995, Tetrahedron Lett., 36, 7761, 10.1016/0040-4039(95)01619-S · DOI
  54. Prakash G. K., 2007, Acc. Chem. Res., 40, 921, 10.1021/ar700149s · DOI
  55. Hale J. J., 1996, J. Med. Chem., 39, 1760, 10.1021/jm950654w · DOI
  56. Rupniak N. M. J., 1997, Eur. J. Pharmacol., 326, 201, 10.1016/S0014-2999(97)85415-5 · DOI
  57. Swain C. J., 1997, Bioorg. Med. Chem. Lett., 7, 2959, 10.1016/S0960-894X(97)10118-4 · DOI
  58. Hale J. J., 1998, J. Med. Chem., 41, 4607, 10.1021/jm980299k · DOI
  59. Humphrey J. M., 2003, Curr. Top. Med. Chem., 3, 1423, 10.2174/1568026033451925 · DOI
  60. Edmondson S. D., 2004, Bioorg. Med. Chem. Lett., 14, 5151, 10.1016/j.bmcl.2004.07.056 · DOI
  61. Kim D., 2005, J. Med. Chem., 48, 141, 10.1021/jm0493156 · DOI
  62. Kim D., 2007, Bioorg. Med. Chem. Lett., 17, 3373, 10.1016/j.bmcl.2007.03.098 · DOI
  63. Uetrecht J., 2007, Annu. Rev. Pharmacol. Toxicol., 47, 513, 10.1146/annurev.pharmtox.47.120505.105150 · DOI
  64. Evans D. C., 2004, Chem. Res. Toxicol., 17, 3, 10.1021/tx034170b · DOI
  65. Hop C. E., 2006, Annual Reports in Medicinal Chemistry, 41, 369
  66. Lin L. S., 2006, J. Med. Chem., 49, 7584, 10.1021/jm060996+ · DOI
  67. Samuel K., 2003, J. Mass Spectrom., 38, 211, 10.1002/jms.434 · DOI
  68. Addy C., 2008, Cell Metab., 7, 1, 10.1016/j.cmet.2007.11.012 · DOI
  69. Scherrmann J.-M., 2006, Compr. Med. Chem. II, 5, 51
  70. Liu L., 2005, Drug Metab. Dispos., 33, 1, 10.1124/dmd.104.001149 · DOI
  71. Sturino C. F., 2007, J. Med. Chem., 50, 794, 10.1021/jm0603668 · DOI
  72. Venkatesan N., 2002, Curr. Med. Chem., 9, 2243, 10.2174/0929867023368692 · DOI
  73. Zanda M., 2004, New J. Chem., 28, 1401, 10.1039/b405955g · DOI
  74. Palmer J. T., 2005, J. Med. Chem., 48, 7520, 10.1021/jm058198r · DOI
  75. Black W. C., 2005, Bioorg. Med. Chem. Lett., 15, 4741, 10.1016/j.bmcl.2005.07.071 · DOI
  76. Li C. S., 2006, Bioorg. Med. Chem. Lett., 16, 1985, 10.1016/j.bmcl.2005.12.071 · DOI
  77. Hughes G., 2007, Angew. Chem., Int. Ed., 46, 1839, 10.1002/anie.200603745 · DOI
  78. Olsen J. A., 2003, Angew. Chem., Int. Ed., 42, 2507, 10.1002/anie.200351268 · DOI
  79. Penning T. D., 1997, J. Med. Chem., 40, 1347, 10.1021/jm960803q · DOI
  80. Khetan S. K., 2007, Chem. Rev., 107, 2319, 10.1021/cr020441w · DOI
  81. Halford B., 2008, Chem. Eng. News, 16, 13
  82. Perez S., 2007, Trends Anal. Chem., 26, 494, 10.1016/j.trac.2007.05.004 · DOI

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Metadata

Authors
Hagmann, W. K.
Affiliations
Merck Research Laboratories, Rahway, New Jersey 07065
Venue
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Published
2008-06-21
Volume
51
Issue
15
Pages
4359-4369
ISSN
  • 0022-2623
  • 1520-4804
DOI
10.1021/jm800219f
Cited by
3,578
References
2
Language
en

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