Fluorinated pyrimidines, a new class of tumour-inhibitory compounds
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5-FU inhibits thymidylate synthase, limiting thymidine nucleotides for DNA synthesis, and 5-FU and capecitabine remain widely used and important for gastrointestinal cancers.
“The pyrimidine analogue 5-fluorouracil (5-FU) is a synthetic analogue of uracil that inhibits thymidylate synthase, limiting the availability of thymidine nucleotides for DNA synthesis (Figure 1b, Figure 2c). 5-FU and the related 5-FU-prodrug capecitabine remain widely used chemotherapies today and are an important treatment for gastrointestinal cancers (Heidelberger et al., 1957; Wagner et al., 2”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Heidelberger et al., 1957
Cites
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- Authors
- HEIDELBERGER, C., CHAUDHURI, N. K., DANNEBERG, P., MOOREN, D., GRIESBACH, L., DUSCHINSKY, R., SCHNITZER, R. J., PLEVEN, E., & SCHEINER, J.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- Nature
- Published
- 1957-03
- Volume
- 179
- Issue
- 4561
- Pages
- 663-666
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1980253503
- Cited by
- 1,603
- References
- 12
- Citations by year
- 2026: 29 · 2025: 44 · 2024: 51 · 2023: 45 · 2022: 48 · 2021: 57 · 2020: 51 · 2019: 51 · 2018: 40 · 2017: 58 · 2016: 57 · 2015: 61 · 2014: 59 · 2013: 37 · 2012: 44
- FWCI
- 18.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer therapeutics and mechanisms
- Keywords
- fluorinated pyrimidines, anticancer agents, fluoropyrimidine, 5-fluorouracil, tumor growth inhibition, fluorinated heterocycles, pyrimidine synthesis, fluorinated amines, fluorinated amino acids, fluorinated steroids, fluorinated carboxylic acids, fluorinated alcohols, fluorinated ethers
- MeSH terms
- Neoplasms, Orotic Acid, Pyrimidines, Uracil, Halogenation
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