Structure of curacin A, a novel antimitotic, antiproliferative and brine shrimp toxic natural product from the marine cyanobacterium Lyngbya majuscula

Gerwick, William H., Proteau, Philip J., Nagle, Dale G., Hamel, Ernest, Blokhin, Andrei, Slate, Doris L.·1994·The Journal of Organic Chemistry
DOI 10.1021/jo00085a006

Cited by (370)

Items 301–370 of 370

  1. Microalgae and Cyanobacteria: A Potential Source for Drug Discovery Using Genome Mining Approach
    David Wiseman Lamare, Neha Chaurasia · 2022 · Clean Energy Production Technologies
  2. Potent anticancer compounds from the ocean
    Pt. Kartikay Pandey, ey, Chakra Chalamala · 2013 · International Journal of Biodiversity and Conservation
  3. Electron ionisation mass spectral studies of bridgehead‐fused Δ 2 ‐norbornanethiazolines
    Antonio García Martínez, Enrique Teso Vilar, Florencio Moreno, Paloma Martínez‐Ruiz, Ricardo Bernárdez Vilaboa · 2009 · Rapid Communications in Mass Spectrometry
  4. Heterocycles from Cyanobacteria
    Tatsufumi Okino · 2006 · Springer eBooks
  5. In silico studies and anticancer evaluation of thiazole–pyrazine–thiadiazole amide derivatives: Synthesis, cytotoxic screening, and molecular insights
    Swapna Maarepalli, Savita Belwal, P. Muralidhar Reddy, Suman Suman, Sailam Sri Gogula · 2025 · Results in Chemistry
  6. Annulative Coupling of β‐Ketosulfoxonium Ylides and β‐Ketothioamides: Access to Thiazolines and Thiazolidin‐4‐Ones
    Rahul Kumar Saini, Satyendra Kumar Pandey · 2024 · Advanced Synthesis & Catalysis
  7. Morphogenetic variation and assorted biological activities in true branching Nostocales strains of Cholistan oasis, Pakistan
    Farooq Inam, Abdul Samad Mumtaz, Muhammad Kaleem, Imran Sajid · 2022 · Journal of Basic Microbiology
  8. Increasing the natural biodiversity of microbial lipopeptides using a synthetic biology approach
    Alexis C. R. Hoste, Sigrid Görgen, Philippe Jacques · 2023 · Elsevier eBooks
  9. Assessing the status of Ichkeul Lake and its catchment through identifying potentially toxic cyanobacteria, simultaneously extracted metals and use of acid-volatile-sulfide model
    Lamia Trabelsi, Bochra Brik, Abdulmohsin J. Alamoudi, Meshal Alshamrani, Noureddine Zaaboub, Afef Fathalli, Lotfi Aleya · 2023 · Marine Pollution Bulletin
  10. Recent developments in using plant-derived natural products as tubulin inhibitors for the management of cancer
    Yogesh Anant Kulkarni, Mayuresh Sudamrao Garud, Ram S. Gaud, Anil Bhanudas Gaikwad · 2016 · Elsevier eBooks
  11. Molecular Targets of Anticancer Agents from Filamentous Marine Cyanobacteria
    Lik Tong Tan, Deepak Kumar Gupta · 2014 · Springer eBooks
  12. Cyanobacterial bioactive compounds : biosynthesis, evolution, structure and bioactivity
    Shishido Joutsen, Tânia Keiko · 2015
  13. Anticancer Compounds from Marine Microorganisms
    Hee Young Shin · 2012 · CRC Press eBooks
  14. ChemInform Abstract: Structure of Curacin A (I), a Novel Antimitotic, Antiproliferative, and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majuscula.
    William H. Gerwick, Philip Proteau, Dale G. Nagle, Ernest Hamel, Andrei V. Blokhin, Doris L. Slate · 1994 · ChemInform
  15. ANTIMICROBIAL ACTIVITY OF AN EGYTPTIAN MARINE CYANOBACTERIUM LYNGBYA MAJUSCULA GOMONT
    Zakaria A. Mohamed, Mohamed Ahmed Abdel-Wahab, Hassan M. El-Sharouny · 2002 · Egyptian journal of phycology
  16. Issues and Challenges of Drug Development from Cyanobacteria
    Sikha Mandal, Jnanendra Rath · 2014 · SpringerBriefs in pharmaceutical science & drug development
  17. Isolation and Structure Elucidation of Antiproliferative Natural Products from Madagascar
    Brian T. Murphy · 2007 · VTechWorks (Virginia Tech)
  18. Harnessing engineered cyanobacteria for next-generation therapeutics
    Alka Bhardwaj, Arun Kumar Mishra · 2026 · Archives of Microbiology
  19. Antimicrobial Peptides Derived from Ascidians and Associated Cyanobacteria
    Rajaian Pushpabai Rajesh, Grace Vanathi M · 2022 · IntechOpen eBooks
  20. Review Biomedical Compounds from Marine organisms
    Rajeev Kumar Jha, Xu Zi-rong · 2014
  21. Antimutagenic, Antiinflammatory, and Potential Anticancer Substances from Marine Algae
    William H. Gerwick · 1997 · Springer eBooks
  22. Anticancer activity of natural compounds from marine plants
    Bimal Krishna Banik, Aparna Das · 2024 · Elsevier eBooks
  23. BIOMEDICAL POTENTIALS OF INTERTIDAL MARINE ORGANISMS FROM SINGAPORE
    Alfred Wai Ping Seng, Yan Zhi Ong, Wan Yen Lee, Peter Peng Foo Lee, S. L. Lim, Koh Siang Tan, Lik Tong Tan · 2007 · Journal of Coastal Zone Management
  24. Synthesis, characterization and apoptosis induction by cyanobacteria-derived neurotoxins: evaluating L-BMAA, 2,4-DAB, and AEG as potential anticancer agents against brain and breast cancer cells
    Chandrabose Uthra, Karuppiah Nagaraj, Gangatharan Muralitharan, Mysoon M. Al‐Ansari, Gunasekaran Velmurugan · 2025 · Chemical Papers
  25. A Wagner–Meerwein‐Like Rearrangement Generates a Vinyl Group in the Biosynthesis of the Polychlorinated Lipopeptides Fischerazoles
    Sandra A. C. Figueiredo, Kathleen Abt, Konrad Viehrig, P. J. Jervis, Teresa P. Martins, Iñaki Lacomba, Chuhan Li, Daniele Castagnolo, Pedro Nuno Leão · 2026 · Angewandte Chemie International Edition
  26. INSECTICIDAL PROPERTIES OF SECONDARY METABOLITES PRODUCED BY AN ENDOLICHENIC FUNGUS, Penicillium pinophilum AGAINST STORED GRAIN INSECT PESTS, Callosobruchus maculatus
    M.P.M. Cooray, T. Gobika, Priyani Ashoka Paranagama · 2017 · Internationalm conference on bioscience and biotechnology
  27. Use of bioprospecting approach to reveal the potential of various algal species for value added compounds
    Subhabrata Ghosh, Jayanta Sikdar, Samir Kumar Mukherjee, Sk Tofajjen Hossain · 2021 · Elsevier eBooks
  28. Medicinal Fungi
    Amritpal Singh · 2011 · CRC Press eBooks
  29. Water‐assisted, Highly‐selective and Rapid Synthesis of Cyclopropane Derivatives by a [2+1] Annulation Reaction
    Li‐Jia Liu, Ming Dai, Lei Song, Hui‐Yu Chen, Ming Bian, Yu‐Ning Gao, Zhenjiang Liu · 2022 · ChemistrySelect
  30. Marine Natural Products That Target Microtubules
    Raymond J. Andersen, Dehai Li, Matt Nodwell, Michel Roberge, Wendy Karen Strangman, David E. Williams · 2012 · Springer eBooks
  31. Advances of Microtubule-Targeting Small Molecular Anticancer Agents from Marine Origin
    Xiaobo Wang, Lun Yu, Zhiguo Liu, Pengfei Xu, Huilong Tan, Tao Wu, Wenbin Zeng · 2014 · Springer eBooks
  32. Biosynthetic Principles in Marine Natural Product Systems
    David H. Sherman, Christopher M. Baxter Rath, Jon Mortison, Jamie B. Scaglione, Jeffrey D. Kittendorf · 2012 · Springer eBooks
  33. New bioactive secondary metabolites from cyanobacteria
    Liwei Liu · 2014 · Työväentutkimus Vuosikirja
  34. Discovery and evaluation of anti-cancer agents
    Frankie Lam · 2010 · Nottingham ePrints (University of Nottingham)
  35. Genomics of the Biosynthesis of Natural Products: From Genes to Metabolites
    Olivier Ploux, Annick Méjean · 2014
  36. Enzymatic Halogenation in Stereoselective Synthesis
    Cormac D. Murphy, Benjamin R. Clark · 2013 · Wiley eBooks
  37. Plant Sources of Drugs and Chemicals
    William H. Gerwick, Brian L. Márquez, Kenneth E. Milligan, Lik Tong Tan, Thomas Williamson · 2001 · Elsevier eBooks
  38. Microalgae colonization and trace element accumulation on the plastisphere of marine plastic debris in Monastir Bay (Eastern Tunisia)
    Mondher Tarchi, Noureddine Zaaboub, Majed Alsubih, Bochra Brik, Maria Virgínia Alves Martins, Lotfi Aleya, Lamia Trabelsi · 2022 · Research Square
  39. Cianopeptídeos inibidores de proteases produzidos por cianobactérias brasileiras
    Joseane Sampaio · 2012
  40. Microbes to Man: From Soils and the Depths to Drugs
    David J. Newman, Gordon M. L. Cragg · 2010 · Burger's Medicinal Chemistry and Drug Discovery
  41. Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412
    Si-Sun Choi, Eung‐Soo Kim · 2008 · Journal of Biotechnology
  42. Cyanobacteria: Can a Toxic Foe Become a Therapeutic Friend? Costantino V*
    Valeria Costantino, Carlo De Sterlich · 2016 · Journal of Oceanography and Marine Research
  43. Phylogeny of tropical marine oscillatoria and correlation with biologically active secondary metabolites
    T. L. Chris Chan · 2011 · eScholarship (California Digital Library)
  44. Bioprospecting and Insights into the Biosynthesis of Natural Products from Marine Microalgae
    Angela H. Soeriyadi, Sarah E. Ongley, C. Romanis, B. Neilan · 2018 · Blue Biotechnology
  45. Isolation and characterization of bioactive compound from Combretum erythrophyllum leaf extracts
    Imelda Ledwaba · 2012
  46. Volume 3 References
    1996 · Elsevier eBooks
  47. Further Reading
    Amritpal Singh · 2006 · CRC Press eBooks
  48. Eubacteria – 2
    Jean‐Michel Kornprobst · 2014 · Wiley eBooks
  49. References
    2004 · CRC Press eBooks
  50. Special Issue in Honor of Professor William Gerwick
    Roger G. Linington, Lena Keller, Hyukjae Choi, Matthew J. Bertin · 2022 · Journal of Natural Products
  51. C
    John Buckingham · 1997 · Springer eBooks
  52. Antimicrobial and Cytotoxic Assessment of Marine Cyanobacteria - Synechocystis and Synechococcus
    Rosário F. Martins · 2008 · Marine Drugs
  53. Antibacterial assay of cyanobacteria in invitro conditions and its valuable applications
    Thanighai arassu ramalingham, Arumugam gangapillai · 2023 · International Journal of Science and Research Archive
  54. Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Inhibitors Isolated from Subtropical Marine Cyanobacteria in Japan
    Arihiro Iwasaki · 2023 · Springer eBooks
  55. Harnessing nature's potential: Exploring the possibilities for disease therapeutics from algae
    Jyoti Kant Choudhari, J. Anandkumar, Jyotsna Choubey, Abhishek Tripathi, Shivangi Pandey, Biju Prava Sahariah · 2025 · Elsevier eBooks
  56. Cyanobacteria as a source of secondary metabolites
    Vandana Sindhu, Sanjay Sharma, Satya Shila Singh · 2025 · Elsevier eBooks
  57. The significance of biosynthetic pathways in uncovering the bioactive potential of marine organisms for drug discovery
    Apexa Gajjar, Asmita Dhimmar, Harshal Sahastrabudhe, Pooja Vishwakarma, Usha P. Shinde, Pramod B. Shinde · 2025 · Elsevier eBooks
  58. Majusculamide-o, a simplified marine natural product analog, exhibits potent and specific cancer cell cytotoxicity
    Niklas Alexander Wahl, Naiara Lebrón-Acosta, Michelle Pérez-Cuevas, Angel Hernandez-Mejias, Dmitry R. Leshchiner, Frederick A. Valeriote, Eduardo J. E. Caro‐Diaz, Sachi Horibata · 2025 · Scientific Reports
  59. Markers of resilience to stony coral tissue loss disease and probiotic potential in the microbiome of the threatened coral, Orbicella faveolata
    Cynthia C. Becker, Allison R. Cauvin, Karen L. Neely, Caroline E. Dennison, Andrew Charles Baker, Brian K. Walker, Julie L. Meyer · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  60. A marvelous hope in the treatment of breast cancer: Moorena producens as an incredible source of bioactive metabolites with a variety of unique selective molecular mechanisms
    Esraa M. Abdelhady, Mona M. Hashem, Mohammed N. A. Khalil, Omar M. Sabry · 2026 · Future Journal of Pharmaceutical Sciences
  61. Algal peptides: diversity, roles, relation to plant peptide science, and applications in crop improvement
    Ranjith Kumar Bakku · 2026 · Elsevier eBooks
  62. A Wagner–Meerwein‐Like Rearrangement Generates a Vinyl Group in the Biosynthesis of the Polychlorinated Lipopeptides Fischerazoles
    Sandra A. C. Figueiredo, Kathleen Abt, Konrad Viehrig, P. J. Jervis, Teresa P. Martins, Iñaki Lacomba, Chuhan Li, Daniele Castagnolo, Pedro Nuno Leão · 2026 · Angewandte Chemie
  63. Synthesis of Benzoxazole-Thiazole-1,3,4-Thiadiazole-Urea Derivatives: In Silico Studies and In Vitro Anticancer Evaluation
    Garikipati Karuna Deepthi, G. Jeevan Raghavendra, Bhuvan Tej Mandava, Venkatarama Venugopal Durvasula, Deepti Kolli, Mandava Venkata Basaveswara Rao · 2026 · Organic Preparations and Procedures International
  64. Stereodivergent synthesis of multi-substituted 1,3-dienes via tandem allylation/Peterson olefination
    Qingbin Lu, Ruibo Li, Shengqiang Li, Aijun Lin, Xuanyi Li, Shang Gao · 2026 · Chemical Communications
  65. Synthesis of 2-Substituted Thiazolines via Efficient Tandem C–X/C–S Bond Formation
    Xuehui Zhang, Shuo Wang, Wenjie Liu, Yajie Fu, Junchen Li, Enxue Shi · 2026 · International Journal of Molecular Sciences
  66. BindingDB Entry 50001946: Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium.
    BindingDB · 2020 · UC San Diego
  67. BindingDB Entry 50018746: Recent advances in chemistry and bioactivity of marine cyanobacteria Moorea species.
    BindingDB · 2024 · UC San Diego
  68. BindingDB Entry 50011935: Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A.
    BindingDB · 2009 · UC San Diego
  69. BindingDB Entry 50046378: Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria.
    BindingDB · 2016 · UC San Diego
  70. BindingDB Entry 50004048: Dolastatin 3 and two novel cyclic peptides from a palauan collection of Lyngbya majuscula.
    BindingDB · 2020 · UC San Diego