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Aigialomycins A−E, New Resorcylic Macrolides from the Marine Mangrove Fungus Aigialus parvus
Abstract
Aigialomycins A-E (2-6), new 14-membered resorcylic macrolides, were isolated together with a known hypothemycin (1) from the mangrove fungus, Aigialus parvus BCC 5311. Structures of these compounds, including absolute configuration, were elucidated by spectroscopic methods, chemical conversions, and X-ray crystallographic analysis. Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC(50) values of 2.2 and 6.6 microg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated.
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Citations
Cited by
Marine-derived fungi: a chemically and biologically diverse group of microorganisms
Bugni, T. S., & Ireland, C. M. (2004) · Natural Product Reports · doi:10.1039/b301926h · Cited by 760
Bhadury, P., Mohammad, B. T., & Wright, P. C. (2006) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-005-0070-3 · Cited by 250
Metadata
- Authors
- Isaka, M., Suyarnsestakorn, C., Tanticharoen, M., Kongsaeree, P., & Thebtaranonth, Y.
- Venue
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-02-07
- Volume
- 67
- Issue
- 5
- Pages
- 1561-1566
- ISSN
- 0022-3263 (ISSN-L)
- 1520-6904
- OpenAlex
- W1977450957
- Cited by
- 219
- References
- 0
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Aigialomycins A−E, New Resorcylic Macrolides from the Marine Mangrove Fungus Aigialus parvus. https://app.cochat.ai/papers/10.1021/jo010930g
- The paper
- Isaka, M., Suyarnsestakorn, C., Tanticharoen, M., Kongsaeree, P., & Thebtaranonth, Y. (2002). Aigialomycins A−E, New Resorcylic Macrolides from the Marine Mangrove Fungus Aigialus parvus. The Journal of Organic Chemistry. https://doi.org/10.1021/jo010930g
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