The current status of natural products from marine fungi and their potential as anti-infective agents
Open accessAbstract
A growing number of marine fungi are the sources of novel and potentially life-saving bioactive secondary metabolites. Here, we have discussed some of these novel antibacterial, antiviral, antiprotozoal compounds isolated from marine-derived fungi and their possible roles in disease eradication. We have also discussed the future commercial exploitation of these compounds for possible drug development using metabolic engineering and post-genomics approaches.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Marine-derived fungi represent a rich and promising source of novel anticancer agents.
“Marine-derived fungi represent a rich and promising source of novel anticancer agents [135,136].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [136]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Miletzki, B., & Gleiter, C. H. (2005) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-005-1024-7 · Cited by 9,401 · see citing works
Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,880 · see citing works
The crisis in antibiotic resistance
Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834 · see citing works
Natural Products in Drug Discovery and Development
Cragg, G. M. L., Newman, D. J., & Snader, K. M. (1997) · Journal of Natural Products · doi:10.1021/np9604893 · Cited by 1,589 · see citing works
Toward a Science of Metabolic Engineering
Bailey, J. E. (1991) · Science · doi:10.1126/science.2047876 · Cited by 1,170 · see citing works
Marine-derived fungi: a chemically and biologically diverse group of microorganisms
Bugni, T. S., & Ireland, C. M. (2004) · Natural Product Reports · doi:10.1039/b301926h · Cited by 760 · see citing works
Biotechnological advantages of laboratory-scale solid-state fermentation with fungi
H�lker, U., H�fer, M., & Lenz, J. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1504-3 · Cited by 757 · see citing works
The future challenges facing the development of new antimicrobial drugs
Coates, A. R. M., Hu, Y., Bax, R. P., & Page, C. P. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd940 · Cited by 705 · see citing works
MOLECULAR GENETICS OF POLYKETIDES AND ITS COMPARISON TO FATTY ACID BIOSYNTHESIS
Hopwood, D. A., & Sherman, D. H. (1990) · Annual Review of Genetics · doi:10.1146/annurev.ge.24.120190.000345 · Cited by 675 · see citing works
Barrett, M. P., Burchmore, R., Stich, A., Lázzari, J. O., Frasch, A. C. C., Cazzulo, J. J., & Krishna, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14694-6 · Cited by 673 · see citing works
Marine natural products (1999)
Faulkner, D. J. (2001) · Natural Product Reports · doi:10.1039/b006897g · Cited by 667 · see citing works
Marine natural products and their potential applications as anti-infective agents
Donia, M., & Hamann, M. T. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00655-8 · Cited by 425 · see citing works
Pestalone, a New Antibiotic Produced by a Marine Fungus in Response to Bacterial Challenge
Cueto, M., Jensen, P. R., Kauffman, C. A., et al. (2001) · Journal of Natural Products · doi:10.1021/np0102713 · Cited by 372 · see citing works
Bioactive metabolites of symbiotic marine microorganisms
Kobayashi, J., & Ishibashi, M. (1993) · Chemical Reviews · doi:10.1021/cr00021a005 · Cited by 369 · see citing works
The discovery and development of marine compounds with pharmaceutical potential
Munro, M. H. G., Blunt, J. W., Dumdei, E. J., et al. (1999) · Journal of Biotechnology · doi:10.1016/s0168-1656(99)00052-8 · Cited by 368 · see citing works
Opportunistic Mycoses in the Immunocompromised Host: Experience at a Cancer Center and Review
Anaissie, E. J. (1992) · Clinical Infectious Diseases · doi:10.1093/clinids/14.supplement_1.s43 · Cited by 366 · see citing works
Fungi from marine sponges: diversity, biological activity and secondary metabolites
Höller, U., Wright, A. D., Matthée, G. F., et al. (2000) · Mycological Research · doi:10.1017/s0953756200003117 · Cited by 348 · see citing works
Exploitation of marine algae: biogenic compounds for potential antifouling applications
Bhadury, P., & Wright, P. (2004) · Planta · doi:10.1007/s00425-004-1307-5 · Cited by 327 · see citing works
Self-citationJasplakinolide, a cyclodepsipeptide from the marine sponge, SP.
Crews, P., Manes, L. V., & Boehler, M. A. (1986) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)84645-6 · Cited by 320 · see citing works
Cooper, B. S., Medley, G. F., Stone, S. P., Kibbler, C. C., Cookson, B., Roberts, J. A., Duckworth, G. J., Lai, R., & Ebrahim, S. B. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401324101 · Cited by 308 · see citing works
Walsh, C. T., Chen, H., Keating, T. A., et al. (2001) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(00)00235-0 · Cited by 305 · see citing works
An easy and fast test to compare total free radical scavenger capacity of foodstuffs
Soler‐Rivas, C., Espı́n, J. C., & Wichers, H. J. (2000) · Phytochemical Analysis · doi:10.1002/1099-1565(200009/10)11:5 · Cited by 298 · see citing works
Reyburn, H. (2005) · JAMA · doi:10.1001/jama.293.12.1461 · Cited by 294 · see citing works
Solid-state fermentation: a promising microbial technology for secondary metabolite production
Robinson, T., Singh, D. N., & Nigam, P. S. N. (2001) · Applied Microbiology and Biotechnology · doi:10.1007/s002530000565 · Cited by 285 · see citing works
Genomes OnLine Database (GOLD): a monitor of genome projects world-wide
Bernal, A. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.1.126 · Cited by 285 · see citing works
ChemInform Abstract: Marine Natural Products
Faulkner, D. J. (1995) · ChemInform · doi:10.1002/chin.199504291 · Cited by 272 · see citing works
PENICILLIN AND CEPHALOSPORIN BIOSYNTHETIC GENES: Structure, Organization, Regulation, and Evolution
Aharonowitz, Y., Cohen, G., & Martin, J. F. (1992) · Annual Review of Microbiology · doi:10.1146/annurev.mi.46.100192.002333 · Cited by 270 · see citing works
Díez, B., Gutiérrez, S., Barredo, J. L., et al. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46231-4 · Cited by 243 · see citing works
Brooker, S., Clarke, S., Njagi, J. K., Polack, S., Mugo, B., Estambale, B., Muchiri, E., Magnussen, P., & Cox, J. (2004) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2004.01272.x · Cited by 231 · see citing works
Aigialomycins A−E, New Resorcylic Macrolides from the Marine Mangrove Fungus Aigialus parvus
Isaka, M., Suyarnsestakorn, C., Tanticharoen, M., et al. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo010930g · Cited by 219 · see citing works
Du, L., Sánchez, C., & Shen, B. (2001) · Metabolic Engineering · doi:10.1006/mben.2000.0171 · Cited by 211 · see citing works
Huang, J., Lih, C., Pan, K., & Cohen, S. N. (2001) · Genes & Development · doi:10.1101/gad.943401 · Cited by 209 · see citing works
Handbook of Industrial Mycology
(2004) · CRC Press eBooks · doi:10.1201/9780203970553 · Cited by 203 · see citing works
Pietra, F. (1997) · Natural Product Reports · doi:10.1039/np9971400453 · Cited by 203 · see citing works
Highlights of marine natural products chemistry (1972–1999)
Faulkner, D. J. (2000) · Natural Product Reports · doi:10.1039/a909113k · Cited by 201 · see citing works
Garo, E., Starks, C. M., Jensen, P. R., et al. (2003) · Journal of Natural Products · doi:10.1021/np0204390 · Cited by 189 · see citing works
Demain, A. L. (2000) · Biotechnology Advances · doi:10.1016/s0734-9750(00)00049-5 · Cited by 185 · see citing works
Stachelhaus, T., & Marahiel, M. A. (1995) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1995.tb07328.x · Cited by 181 · see citing works
Mayer, A. M. S., & Hamann, M. T. (2004) · Marine Biotechnology · doi:10.1007/s10126-003-0007-7 · Cited by 178 · see citing works
Bioactive Metabolites from a Marine-Derived Strain of the Fungus Emericella variecolor
Malmstrøm, J., Christophersen, C., Barrero, A. F., et al. (2002) · Journal of Natural Products · doi:10.1021/np0103214 · Cited by 175 · see citing works
Salomon, C. E., Magarvey, N. A., & Sherman, D. H. (2004) · Natural Product Reports · doi:10.1039/b301384g · Cited by 172 · see citing works
New Metabolites from Sponge-Derived Fungi Curvularia lunata and Cladosporium herbarum
Jadulco, R. C., Brauers, G., Edrada‐Ebel, R., et al. (2002) · Journal of Natural Products · doi:10.1021/np010390i · Cited by 170 · see citing works
Containment of Antibiotic Resistance
Williams, R. J., & Heymann, D. L. (1998) · Science · doi:10.1126/science.279.5354.1153 · Cited by 169 · see citing works
Piel, J., Hertweck, C., Shipley, P. R., et al. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00044-2 · Cited by 169 · see citing works
New dimensions in natural products research: Cultured marine microorganisms
Davidson, B. (1995) · Current Opinion in Biotechnology · doi:10.1016/0958-1669(95)80049-2 · Cited by 168 · see citing works
Faulkner, D. J. (2000) · Antonie van Leeuwenhoek · doi:10.1023/a:1002405815493 · Cited by 168 · see citing works
The bioprocess–technological potential of the sea
Pomponi, S. A. (1999) · Journal of Biotechnology · doi:10.1016/s0168-1656(99)00053-x · Cited by 164 · see citing works
Li, A., & Piel, J. (2002) · Chemistry & Biology · doi:10.1016/s1074-5521(02)00223-5 · Cited by 159 · see citing works
Three New Metabolites from Marine-Derived Fungi of the Genera Coniothyrium and Microsphaeropsis
Höller, U., König, G. M., & Wright, A. D. (1998) · Journal of Natural Products · doi:10.1021/np980341e · Cited by 156 · see citing works
Natural Products with Anti-HIV Activity from Marine Organisms
Tziveleka, L., Vagias, C., & Roussis, V. (2003) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026033451790 · Cited by 155 · see citing works
Osterhage, C., Kaminsky, R., König, G. M., et al. (2000) · The Journal of Organic Chemistry · doi:10.1021/jo000307g · Cited by 155 · see citing works
MacCabe, A., Riach, M. B. R., Unkles, S. E., & Kinghorn, J. R. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08106.x · Cited by 140 · see citing works
New Secondary Metabolites from the Marine Endophytic Fungus Apiospora montagnei
Klemke, C., Kehraus, S., Wright, A. D., et al. (2004) · Journal of Natural Products · doi:10.1021/np034061x · Cited by 134 · see citing works
Biomedical Importance of Marine Organisms
Fautin, D. G. (2017) · Medical Entomology and Zoology · Cited by 129 · see citing works
A REVIEW OF THE CLINICAL AND EPIDEMIOLOGIC BURDENS OF EPIDEMIC MALARIA
Kiszewski, A. E., & Teklehaimanot, A. (2004) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2004.71.128 · Cited by 128 · see citing works
Thalassiolins A–C: new marine-derived inhibitors of HIV cDNA integrase
Rowley, D. C., Hansen, M. S. T., Rhodes, D., Sotriffer, C., Ni, H., McCammon, J. A., Bushman, F. D., & Fenical, W. (2002) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(02)00241-9 · Cited by 126 · see citing works
From natural products to clinically useful antifungals
Barrett, D. G. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(02)00085-6 · Cited by 126 · see citing works
Edrada‐Ebel, R., Heubes, M., Brauers, G., et al. (2002) · Journal of Natural Products · doi:10.1021/np020085c · Cited by 121 · see citing works
Two New Xanthone Derivatives from the Algicolous Marine Fungus Wardomyces anomalus
Abdel‐Lateff, A., Klemke, C., König, G. M., & Wright, A. D. (2003) · Journal of Natural Products · doi:10.1021/np020518b · Cited by 119 · see citing works
Jadulco, R. C., Proksch, P., Wray, V., et al. (2001) · Journal of Natural Products · doi:10.1021/np000401s · Cited by 116 · see citing works
Recent advances in identifying and validating drug targets in trypanosomes and leishmanias
Barrett, M. P., Coombs, G. H., & Mottram, J. C. (1999) · Trends in Microbiology · doi:10.1016/s0966-842x(98)01433-4 · Cited by 114 · see citing works
Mechanism of Inhibition of a Poxvirus Topoisomerase by the Marine Natural Product Sansalvamide A
Hwang, Y. S., Rowley, D. C., Rhodes, D., Gertsch, J., Fenical, W., & Bushman, F. D. (1999) · Molecular Pharmacology · doi:10.1124/mol.55.6.1049 · Cited by 108 · see citing works
The Metacyclophanediene-Dihydropyrene Photochromic π Switch
Mitchell, R. H. (1999) · European Journal of Organic Chemistry · doi:10.1002/(sici)1099-0690(199911)1999:11 · Cited by 107 · see citing works
Unusual C25 Steroids Produced by a Sponge-Derived Penicillium citrinum
Amagata, T., Amagata, A., Tenney, K., et al. (2003) · Organic Letters · doi:10.1021/ol0356800 · Cited by 107 · see citing works
New aspects of genes and enzymes for β-lactam antibiotic biosynthesis
Martı́n, J.-F. (1998) · Applied Microbiology and Biotechnology · doi:10.1007/s002530051249 · Cited by 104 · see citing works
Silber, A. M., Colli, W., Ulrich, H., et al. (2005) · Current Drug Targets - Infectious Disorders · doi:10.2174/1568005053174636 · Cited by 104 · see citing works
Mayer, A. M. S., & Hamann, M. T. (2002) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(02)00094-7 · Cited by 103 · see citing works
New pharmaceuticals from marine organisms
Fenical, W. (1997) · Trends in biotechnology · doi:10.1016/s0167-7799(97)01081-0 · Cited by 102 · see citing works
A New Antibiotic CJ-17,665 from Aspergillus ochraceus.
Sugie, Y., Hirai, H., INAGAKI, T., et al. (2001) · The Journal of Antibiotics · doi:10.7164/antibiotics.54.911 · Cited by 101 · see citing works
Marine Microorganisms: A New Biomedical Resource
Fenical, W., & Jensen, P. R. (1993) · Springer eBooks · doi:10.1007/978-1-4899-2391-2_12 · Cited by 100 · see citing works
Biological Activities of Selected Marine Natural Products
König, G. M., Wright, A., Sticher, O., et al. (1994) · Planta Medica · doi:10.1055/s-2006-959565 · Cited by 94 · see citing works
Modiolides A and B, Two New 10-Membered Macrolides from a Marine-Derived Fungus
Tsuda, M., Mugishima, T., Komatsu, K., et al. (2003) · Journal of Natural Products · doi:10.1021/np0203943 · Cited by 92 · see citing works
Toske, S. G., Jensen, P. R., Kauffman, C. A., et al. (1998) · Tetrahedron · doi:10.1016/s0040-4020(98)00829-1 · Cited by 92 · see citing works
Speradine A, a new pentacyclic oxindole alkaloid from a marine-derived fungus Aspergillus tamarii
Tsuda, M., Mugishima, T., Komatsu, K., et al. (2003) · Tetrahedron · doi:10.1016/s0040-4020(03)00413-7 · Cited by 92 · see citing works
Minagawa, K., KOUZUKI, S., Yoshimoto, J., et al. (2002) · The Journal of Antibiotics · doi:10.7164/antibiotics.55.155 · Cited by 91 · see citing works
Halovirs A–E, new antiviral agents from a marine-Derived fungus of the genus Scytalidium
Rowley, D. C. (2003) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(03)00395-x · Cited by 91 · see citing works
Marine-derived anticancer agents in clinical trials
Schwartsmann, G., da Rocha, A. B., Mattei, J., & Lopes, R. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.8.1367 · Cited by 91 · see citing works
Antimalarial halorosellinic acid from the marine fungus Halorosellinia oceanica
Chinworrungsee, M., Kittakoop, P., Isaka, M., et al. (2001) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00327-4 · Cited by 88 · see citing works
Altomare, C., Perrone, G., Zonno, M. C., et al. (2000) · Journal of Natural Products · doi:10.1021/np000023r · Cited by 88 · see citing works
Lin, W., Brauers, G., Ebel, R., et al. (2002) · Journal of Natural Products · doi:10.1021/np020196b · Cited by 87 · see citing works
Malakoff, D. (1997) · Science · doi:10.1126/science.277.5325.486 · Cited by 86 · see citing works
Aspergillicins A–E: five novel depsipeptides from the marine-derived fungus Aspergillus carneus
Capon, R. J., Skene, C. E., Stewart, M., Ford, J., O’Hair, R. A. J., Williams, L., Lacey, E., Gill, J. H., Heiland, K., & Friedel, T. (2003) · Organic & Biomolecular Chemistry · doi:10.1039/b302306k · Cited by 84 · see citing works
Total Synthesis of Aigialomycin D
Geng, X., & Danishefsky, S. J. (2004) · Organic Letters · doi:10.1021/ol036258m · Cited by 84 · see citing works
Cyclosporin-A production by Tolypocladium inflatum using solid state fermentation
Murthy, M. V. R., Mohan, E. V. S., & Sadhukhan, A. K. (1999) · Process Biochemistry · doi:10.1016/s0032-9592(98)00095-8 · Cited by 81 · see citing works
A New Antioxidant Isobenzofuranone Derivative from the Algicolous Marine FungusEpicoccumsp.
Abdel‐Lateff, A., Fisch, K. M., Wright, A. D., & König, G. M. (2003) · Planta Medica · doi:10.1055/s-2003-43209 · Cited by 80 · see citing works
Antibiotics from basidiomycetes
Kupka, J., Anke, T., Giannetti, B. M., et al. (1981) · Archives of Microbiology · doi:10.1007/bf00459523 · Cited by 79 · see citing works
Rare Sesquiterpenes from the Algicolous Fungus Drechslera dematioidea
Osterhage, C., König, G. M., Höller, U., et al. (2002) · Journal of Natural Products · doi:10.1021/np010092l · Cited by 79 · see citing works
Li, X., Kim, M. K., Lee, U., Kim, S., Kang, J. S., Choi, H. D., & Son, B. W. (2005) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.53.453 · Cited by 78 · see citing works
Methicillin‐resistant Staphylococcus aureus in community‐acquired pyoderma
Nagaraju, U., Bhat, G. K., Kuruvila, M., Ganesh, S., Jayalakshmi, & Ravindra, P. (2004) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2004.02138.x · Cited by 76 · see citing works
Diagnosis & management of leishmania/HIV co-infection.
Sinha, P. K., Pandey, K., & Bhattacharya, S. (2005) · PubMed · Cited by 76 · see citing works
Renner, M. K., Jensen, P. R., & Fenical, W. (1998) · The Journal of Organic Chemistry · doi:10.1021/jo981226b · Cited by 76 · see citing works
It's Not a Spider Bite, It's Community-Acquired Methicillin-Resistant Staphylococcus aureus
Dominguez, T. J. (2004) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.17.3.220 · Cited by 75 · see citing works
Namikoshi, M., Kobayashi, H., YOSHIMOTO, T., et al. (2000) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.48.1452 · Cited by 75 · see citing works
Wang, G.-Y.-S., Abrell, L. M., Avelar, A., et al. (1998) · Tetrahedron · doi:10.1016/s0040-4020(98)00398-6 · Cited by 73 · see citing works
Prevention of MRSA pneumonia by oral vancomycin decontamination: a randomised trial
Silvestri, L., van Saene, H. K. F., Milanese, M., et al. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00109704 · Cited by 73 · see citing works
Production of Secondary Metabolites by Solid-State Fermentation
Barrios-González, J., & Mejía, A. (1996) · Biotechnology annual review · doi:10.1016/s1387-2656(08)70007-3 · Cited by 72 · see citing works
Halorosellins A and B, unique isocoumarin glucosides from the marine fungus Halorosellinia oceanica
Chinworrungsee, M., Kittakoop, P., Isaka, M., et al. (2002) · Journal of the Chemical Society Perkin Transactions 1 · doi:10.1039/b207887m · Cited by 71 · see citing works
Small-molecule natural products: new structures, new activities
Baker, D. D., & Alvi, K. A. (2004) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2004.09.003 · Cited by 71 · see citing works
Genomic Exploration of the Hemiascomycetous Yeasts: 14. Debaryomyces hansenii var. hansenii
Lépingle, A., Casarégola, S., Neuvéglise, C., et al. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02285-7 · Cited by 69 · see citing works
Daferner, M., Anke, T., & Sterner, O. (2002) · Tetrahedron · doi:10.1016/s0040-4020(02)00942-0 · Cited by 66 · see citing works
Fulfilling the promise of biotechnology
Colwell, R. R. (2002) · Biotechnology Advances · doi:10.1016/s0734-9750(02)00011-3 · Cited by 64 · see citing works
Gautschi, J. T., Amagata, T., Amagata, A., et al. (2004) · Journal of Natural Products · doi:10.1021/np030388m · Cited by 64 · see citing works
.ALPHA.-Aminoadipyl-cysteinyl-valine Synthetases in .BETA.-Lactam Producing Organisms.
Martin, J. F. (2000) · The Journal of Antibiotics · doi:10.7164/antibiotics.53.1008 · Cited by 63 · see citing works
Mathison, L., Soliday, C. L., Stepan, T., et al. (1993) · Current Genetics · doi:10.1007/bf00336747 · Cited by 63 · see citing works
Amplification of HMG-CoA Reductase Production Enhances Carotenoid Accumulation in Neurospora crassa
Wang, G. (2002) · Metabolic Engineering · doi:10.1006/mben.2002.0225 · Cited by 63 · see citing works
Mackenzie, N. M., Dresser, D. W., & Pinder, A. C. (1985) · Immunology Today · doi:10.1016/0167-5699(85)90002-7 · Cited by 63 · see citing works
Lum, A. M., Huang, J., Hutchinson, C. R., et al. (2004) · Metabolic Engineering · doi:10.1016/j.ymben.2003.12.001 · Cited by 61 · see citing works
Cheng, X.-C., Varoglu, M., Abrell, L. M., Crews, P., Lobkovsky, E. B., & Clardy, J. (1994) · The Journal of Organic Chemistry · doi:10.1021/jo00100a041 · Cited by 61 · see citing works
γ-Pyrone derivatives, kojic acid methyl ethers from a marine-derived fungusaltenaria sp
Li, X., Jeong, J. H., Lee, K. T., et al. (2003) · Archives of Pharmacal Research · doi:10.1007/bf02976876 · Cited by 60 · see citing works
Tan, L. T., Cheng, X. C., Jensen, P. R., et al. (2003) · The Journal of Organic Chemistry · doi:10.1021/jo030191z · Cited by 60 · see citing works
Coniosetin, a Novel Tetramic Acid Antibiotic from Coniochaeta ellipsoidea DSM 13856.
Segeth, M. P., Bonnefoy, A., Brönstrup, M., Knauf, M., Schummer, D., Toti, L., Vértesy, L., Wetzel, M.-C., Wink, J. M., & SEIBERT, G. (2003) · The Journal of Antibiotics · doi:10.7164/antibiotics.56.114 · Cited by 59 · see citing works
Development of high penicillin producing strains for solid state fermentation
Barrios-González, J., Castillo, T. E., & Mejía, A. (1993) · Biotechnology Advances · doi:10.1016/0734-9750(93)90021-e · Cited by 56 · see citing works
Pinheiro, R., Belo, I., & Mota, M. (2003) · Letters in Applied Microbiology · doi:10.1046/j.1472-765x.2003.01429.x · Cited by 56 · see citing works
Fungal depside, guisinol, from a marine derived strain of Emericella unguis
Nielsen, J., Nielsen, P. H., & Frisvad, J. C. (1999) · Phytochemistry · doi:10.1016/s0031-9422(98)00517-2 · Cited by 55 · see citing works
Toyomasu, T., Nakaminami, K., Toshima, H., et al. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.146 · Cited by 53 · see citing works
A cyclic carbonate and related polyketides from a marine-derived fungus of the genus Phoma
Liu, Z., Jensen, P. R., & Fenical, W. (2003) · Phytochemistry · doi:10.1016/s0031-9422(03)00272-3 · Cited by 53 · see citing works
Namikoshi, M., Negishi, R., Nagai, H., et al. (2003) · The Journal of Antibiotics · doi:10.7164/antibiotics.56.755 · Cited by 53 · see citing works
Solid-Phase, Pd-Catalyzed Silicon-Aryl Carbon Bond Formation. Synthesis of Sansalvamide A Peptide
Gu, W., Liu, S., & Silverman, R. B. (2002) · Organic Letters · doi:10.1021/ol0269392 · Cited by 52 · see citing works
Schmitt, E. K., Bunse, A., Janus, D., et al. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.1.121-134.2004 · Cited by 52 · see citing works
YM-202204, a New Antifungal Antibiotic Produced by Marine Fungus Phoma sp.
Nagai, K., KAMIGIRI, K., Matsumoto, H., et al. (2002) · The Journal of Antibiotics · doi:10.7164/antibiotics.55.1036 · Cited by 52 · see citing works
Hypoxysordarin, a New Sordarin Derivative from Hypoxylon croceum
Daferner, M., Mensch, S., Anke, T., et al. (1999) · Zeitschrift für Naturforschung C · doi:10.1515/znc-1999-7-803 · Cited by 51 · see citing works
The structure of leptosphaerin
Schiehser, G. A., White, J. D., Matsumoto, G., Pezzanite, J. O., & Clardy, J. (1986) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)85272-7 · Cited by 49 · see citing works
Che, Y., Gloer, J. B., & Wicklow, D. T. (2002) · Journal of Natural Products · doi:10.1021/np010519o · Cited by 49 · see citing works
Nakatani, M., Nakamura, M., Suzuki, A., et al. (2002) · Organic Letters · doi:10.1021/ol0271032 · Cited by 45 · see citing works
Liu, C. H., Meng, J., Zou, W. X., et al. (2002) · Planta Medica · doi:10.1055/s-2002-26756 · Cited by 44 · see citing works
Kupka, J., Anke, T., Steglich, W., et al. (1981) · The Journal of Antibiotics · doi:10.7164/antibiotics.34.298 · Cited by 44 · see citing works
Herpes simplex type 1 and genital herpes in Northern Ireland.
Christie, S. N., McCaughey, C., McBride, M., & Coyle, P. V. (1997) · PubMed · Cited by 43 · see citing works
Li, X., Choi, H. D., Kang, J. S., et al. (2003) · Journal of Natural Products · doi:10.1021/np030231u · Cited by 41 · see citing works
ABSOLUTE CONFIGURATION OF CORIOLIN, A SESQUITERPENE ANTIBIOTIC FROM CORIOLUS CONSORS
Nakamura, H., TAKITA, T., UMEZAWA, H., et al. (1974) · The Journal of Antibiotics · doi:10.7164/antibiotics.27.301 · Cited by 40 · see citing works
YM-215343, a Novel Antifungal Compound from Phoma sp. QN04621
SHIBAZAKI, M., Taniguchi, M., Yokoi, T., et al. (2004) · The Journal of Antibiotics · doi:10.7164/antibiotics.57.379 · Cited by 40 · see citing works
Lee, Y., & Silverman, R. B. (2000) · Organic Letters · doi:10.1021/ol0002830 · Cited by 39 · see citing works
Ketene Acetal and Spiroacetal Constituents of the Marine Fungus Aigialus parvus BCC 5311
Vongvilai, P., Isaka, M., Kittakoop, P., et al. (2004) · Journal of Natural Products · doi:10.1021/np030344d · Cited by 35 · see citing works
Yanai, K., Sumida, N., Okakura, K., et al. (2004) · Nature Biotechnology · doi:10.1038/nbt978 · Cited by 35 · see citing works
JM47, a cyclic tetrapeptide HC-toxin analogue from a marine Fusarium species
Jiang, Z., Barret, M., Boyd, K. G., Adams, D. R., Boyd, A. S. F., & Burgess, J. G. (2002) · Phytochemistry · doi:10.1016/s0031-9422(02)00061-4 · Cited by 35 · see citing works
A new polyketide, secocurvularin, from the salt water culture of a sponge derived fungus
Abrell, L. M., Borgeson, B. M., & Crews, P. (1996) · Tetrahedron Letters · doi:10.1016/s0040-4039(96)02108-9 · Cited by 33 · see citing works
Gallo, M. L., Seldes, A. M., & Cabrera, G. M. (2004) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2003.08.009 · Cited by 33 · see citing works
Seragakinone A, a new pentacyclic metabolite from a marine-derived fungus
Shigemori, H., Komatsu, K., Mikamia, Y., et al. (1999) · Tetrahedron · doi:10.1016/s0040-4020(99)00984-9 · Cited by 33 · see citing works
Stembera, K., Vogel, S., Buchynskyy, A., Ayala, J. A., & Welzel, P. (2002) · ChemBioChem · doi:10.1002/1439-7633(20020603)3:6 · Cited by 31 · see citing works
Engineering biodiversity with type II polyketide synthase genes
Moore, B. S., & Piel, J. (2000) · Antonie van Leeuwenhoek · doi:10.1023/a:1010273224820 · Cited by 31 · see citing works
Ndyomugyenyi, R., & Magnussen, P. (2004) · Annals of Tropical Medicine and Parasitology · doi:10.1179/000349804225003433 · Cited by 31 · see citing works
Fungal genomics beyond Saccharomyces cerevisiae?
Hofmann, G., McIntyre, M., & Nielsen, J. (2003) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(03)00020-x · Cited by 31 · see citing works
Mehta, A. S., Gu, B., Conyers, B., Ouzounov, S., Wang, L., Moriarty, R. M., Dwek, R. A., & Block, T. M. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.6.2085-2090.2004 · Cited by 29 · see citing works
High Prevalence of Herpes Simplex Virus Type 1 in Female Anogenital Herpes Simplex
Rodgers, C. A., & O'Mahony, C. (1995) · International Journal of STD & AIDS · doi:10.1177/095646249500600218 · Cited by 29 · see citing works
Yagi, S., Ono, J., Yoshimoto, J., et al. (1999) · Pharmaceutical Research · doi:10.1023/a:1018983715982 · Cited by 28 · see citing works
Design of a Tubular Loop Bioreactor for Scale‐up and Scale‐down of Fermentation Processes
Papagianni, M., Mattey, M., & Kristiansen, B. (2003) · Biotechnology Progress · doi:10.1021/bp030002y · Cited by 28 · see citing works
Son, B. W., Choi, J. S., Kim, J. C., Nam, K. W., Kim, D.-S., Chung, H. Y., Kang, J. S., & Choi, H. D. (2002) · Journal of Natural Products · doi:10.1021/np010450k · Cited by 27 · see citing works
Kim, C.-F., Lee, S. K. Y., Price, J. F., et al. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.2.1308-1314.2003 · Cited by 23 · see citing works
Non-ribosomal peptide antibiotics
Mankelow, D. P., & Neilan, B. A. (2000) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.10.10.1583 · Cited by 23 · see citing works
Condom breakage and prevention of HIV transmission: an underestimated problem
Eich‐Höchli, D., Niklowitz, M., Sieber, M. F., Opravil, M., & Luthy, R. (1997) · International Journal of STD & AIDS · doi:10.1258/0956462971918689 · Cited by 22 · see citing works
Berk, D., Behie, L. A., Jones, A. R., et al. (1984) · The Canadian Journal of Chemical Engineering · doi:10.1002/cjce.5450620119 · Cited by 22 · see citing works
Antifungal Metabolites from Marine Sponges
Li, H.-Y., Matsunaga, S., & Fusetani, N. (1998) · Current Organic Chemistry · doi:10.2174/1385272802666220130083412 · Cited by 21 · see citing works
Humanitarian assistance should include aspects of sexuality.
Kollie, S., von Roenne, F., & Blankhart, D. (1999) · PubMed · Cited by 20 · see citing works
Cruz, A. J. G., Tai, P., Giordano, R. C., et al. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10877 · Cited by 20 · see citing works
Synthesis of Corollosporine, an Antibacterial Metabolite of the Marine Fungus Corollospora maritima
Ohzeki, T., & Mori, K. (2001) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.65.172 · Cited by 19 · see citing works
Liberra, K., Jansen, R., & Lindequist, U. (1998) · PubMed · Cited by 19 · see citing works
González, I. J., Varela, R. E., Murillo, C., et al. (2003) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(03)90160-x · Cited by 17 · see citing works
Production of L-Phenylacetyl Carbinol by Immobilized Cells of Saccharomyces Cerevisiae
Mandwal, A. K., Tripathi, C. K. M., Trivedi, P. D., et al. (2004) · Biotechnology Letters · doi:10.1023/b:bile.0000013718.88453.f0 · Cited by 16 · see citing works
Höller, U. (1999) · Digitale Bibliothek Braunschweig (Verbundzentrale Göttingen (VZG)) · doi:10.24355/dbbs.084-200511080100-211 · Cited by 16 · see citing works
Liu, C. H., Liu, J. Y., Huang, L. L., et al. (2003) · Planta Medica · doi:10.1055/s-2003-39696 · Cited by 13 · see citing works
Zilinskas, R. A. (1995) · Medical Entomology and Zoology · Cited by 12 · see citing works
Kuznetsova, T. A., Smetanina, O. F., Afiyatullov, S. S., et al. (2001) · Biochemical Systematics and Ecology · doi:10.1016/s0305-1978(00)00102-2 · Cited by 12 · see citing works
Beta-glucan production by Botryosphaeria rhodina in different bench-top bioreactors
Selbmann, L., Crognale, S., & Petruccioli, M. (2004) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2004.02241.x · Cited by 12 · see citing works
WHO warns of threat of "superbugs"
Kmietowicz, Z. (2000) · BMJ · doi:10.1136/bmj.320.7250.1624 · Cited by 9 · see citing works
Kundu, S., Mahapatra, A. C., Nigam, V. K., et al. (2003) · Artificial Cells Blood Substitutes and Biotechnology · doi:10.1081/bio-120023161 · Cited by 7 · see citing works
Luo, J., Yang, Y., Lin, Y.-C., et al. (2004) · PubMed · Cited by 5 · see citing works
High pressure cultivation of marine fungi: Apparatus and method
Lorenz, R. J., & Molitoris, H.-P. (1992) · University of Regensburg Publication Server (University of Regensburg) · Cited by 4 · see citing works
Nakatani, M., Nakamura, M., Suzuki, A., et al. (2003) · ChemInform · doi:10.1002/chin.200317185 · Cited by 4 · see citing works
PP-35 Screening of tyrosinase inhibiting activity from the marine-derived fungus
Lee, G., Lee, S. Y., Jeong, J. H., et al. (2003) · Pigment Cell Research · doi:10.1034/j.1600-0749.2003.83100.x · Cited by 4 · see citing works
Genes directly involved in the biosynthesis of beta-lactam antibiotics.
Barredo, J. L., & Jf, M. (1991) · PubMed · Cited by 3 · see citing works
Bijev, A. T., Nankov, A., Keuleyan, E. E., et al. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1296946 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Colwell RR (1985) Marine polysaccharides for pharmaceuti- cal and microbiological applications. In: Colwell RR, Pariser ER, Sinskey AJ (eds) Biotechnology of marine polysaccha- rides. Proceedings of the 3rd annual MIT seer grant college program lecture and seminar. Hemisphere Publishing, Wash- ington, pp 364-376
- Jensen PR, Fenical W (2002) In: Hyde KD (ed) Fungi in marine environments, vol 7. Fungal diversity, Hong Kong, pp 293-315
- Roizman B, Sears AE (1996) In: Fields B, Knipe DM, Howley PM (eds) Fundamental virology. Lippincott-Raven, Phila- delphia, pp 1043-1107 136.
Cited by
Sorted by citations
Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works
Spampinato, C., & Leonardi, D. (2013) · BioMed Research International · doi:10.1155/2013/204237 · Cited by 411 · see citing works
Immense essence of excellence: Marine microbial bioactive compounds
Bhatnagar, I., & Kim, S.-K. (2010) · Marine Drugs · doi:10.3390/md8102673 · Cited by 384 · see citing works
Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer
Senthilkumar, K., Manivasagan, P., Venkatesan, J., & Kim, S.-K. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.06.030 · Cited by 340 · see citing works
- Authors
- Bhadury, P., Mohammad, B. T., & Wright, P. C.
- Affiliations
- Plymouth Marine Laboratory (GB)
- Universidade da Coruña (ES)
- University of Sheffield (GB)
- Venue
- Journal of Industrial Microbiology & Biotechnology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-01-21
- Volume
- 33
- Issue
- 5
- Pages
- 325-337
- ISSN
- 1367-5435 (ISSN-L)
- 1476-5535
- OpenAlex
- W2090747912
- Cited by
- 250
- References
- 170
- Citations by year
- 2026: 4 · 2024: 7 · 2023: 10 · 2022: 11 · 2021: 13 · 2020: 15 · 2019: 20 · 2018: 12 · 2017: 13 · 2016: 12 · 2015: 11 · 2014: 23 · 2013: 12 · 2012: 27
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Industrial Microbiology & Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Heriot-Watt University
- Department for International Development
- Engineering and Physical Sciences Research Council
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- marine fungi, natural products, secondary metabolites, antibacterial agents, antiviral agents, antiprotozoal agents, anti-infective agents, drug development, metabolic engineering, postgenomics
- MeSH terms
- Anti-Infective Agents, Biological Factors, Fungi, Marine Biology, Molecular Structure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review