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Aiming for the Ideal Synthesis
Abstract
The field of total synthesis has a rich history and a vibrant future. Landmark advances and revolutionary strides in the logic of synthesis have put the practicing chemist in the enviable position of being able to create nearly any molecule with enough time and effort. The stage is now set for organic chemists to aim for "ideality" in the way molecules are synthesized. This perspective presents a simple and informative definition of "ideality" and demonstrates its use during the self-evaluation of several syntheses from our laboratory.
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Cited by
Computer‐Assisted Synthetic Planning: The End of the Beginning
Szymkuć, S., Gajewska, E. P., Klucznik, T., Molga, K., Dittwald, P., Startek, M., Bajczyk, M., & Grzybowski, B. A. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201506101 · Cited by 611
Chemo- and site-selective derivatizations of natural products enabling biological studies
Robles, O., & Romo, D. (2014) · Nat. Prod. Rep. · doi:10.1039/c3np70087a · Cited by 154
Emergence of single-molecular chirality from achiral reactants
Steendam, R. R. E., Verkade, J. M. M., van Benthem, T. J. B., Meekes, H., van Enckevort, W. J. P., Raap, J., Rutjes, F. P. J. T., & Vlieg, E. (2014) · Nature Communications · doi:10.1038/ncomms6543 · Cited by 78
Metadata
- Authors
- Gaich, T., & Baran, P. S.
- Venue
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-06-11
- Volume
- 75
- Issue
- 14
- Pages
- 4657-4673
- ISSN
- 0022-3263 (ISSN-L)
- 1520-6904
- OpenAlex
- W1965536028
- Cited by
- 647
- References
- 0
- FWCI
- 22.57
- Type
- journal article
- Language
- en
- Open access
- closed
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