The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Aiming for the Ideal Synthesis
Abstract
The field of total synthesis has a rich history and a vibrant future. Landmark advances and revolutionary strides in the logic of synthesis have put the practicing chemist in the enviable position of being able to create nearly any molecule with enough time and effort. The stage is now set for organic chemists to aim for "ideality" in the way molecules are synthesized. This perspective presents a simple and informative definition of "ideality" and demonstrates its use during the self-evaluation of several syntheses from our laboratory.
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Citations
Cites
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Self-citationRedox Economy in Organic Synthesis
Burns, N. Z., Baran, P. S., & Hoffmann, R. W. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200806086 · Cited by 769
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Roughley, S. D., & Jordan, A. M. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200187y · Cited by 2,725
Metrics of Green Chemistry and Sustainability: Past, Present, and Future
Sheldon, R. A. (2018) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.7b03505 · Cited by 1,292
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Milligan, J. A., Phelan, J. P., Badir, S. O., & Molander, G. A. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201809431 · Cited by 623
Computer‐Assisted Synthetic Planning: The End of the Beginning
Szymkuć, S., Gajewska, E. P., Klucznik, T., Molga, K., Dittwald, P., Startek, M., Bajczyk, M., & Grzybowski, B. A. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201506101 · Cited by 611
Green Chemistry in the Synthesis of Pharmaceuticals
Kar, S., Sanderson, H., Roy, K., Benfenati, E., & Leszczynski, J. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00631 · Cited by 566
Kille, S., Zilly, F. E., Acevedo, J. P., & Reetz, M. T. (2011) · Nature Chemistry · doi:10.1038/nchem.1113 · Cited by 405
Direct Synthesis of Fluorinated Heteroarylether Bioisosteres
Zhou, Q., Ruffoni, A., Gianatassio, R., Fujiwara, Y., Sella, E., Shabat, D., & Baran, P. S. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201300763 · Cited by 256
Self-citationChemo- and site-selective derivatizations of natural products enabling biological studies
Robles, O., & Romo, D. (2014) · Nat. Prod. Rep. · doi:10.1039/c3np70087a · Cited by 154
Emergence of single-molecular chirality from achiral reactants
Steendam, R. R. E., Verkade, J. M. M., van Benthem, T. J. B., Meekes, H., van Enckevort, W. J. P., Raap, J., Rutjes, F. P. J. T., & Vlieg, E. (2014) · Nature Communications · doi:10.1038/ncomms6543 · Cited by 78
Metadata
- Authors
- Gaich, T., & Baran, P. S.
- Venue
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-06-11
- Volume
- 75
- Issue
- 14
- Pages
- 4657-4673
- ISSN
- 0022-3263 (ISSN-L)
- 1520-6904
- OpenAlex
- W1965536028
- Cited by
- 647
- References
- 63
- FWCI
- 22.57
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
