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Kahalalides: Bioactive Peptides from a Marine Mollusk Elysia rufescens and Its Algal Diet Bryopsis sp. 1
Abstract
In addition to the previously reported bioactive kahalalide F six new peptides are described. Six of these, including kahalalide F, are cyclic depsipeptides, ranging from a C(31) tripeptide to a C(75) tridecapeptide isolated from a sacoglossan mollusk, Elysiarufescens. The mollusk feeds on a green alga, Bryopsis sp., which has also been shown to elaborate some of these peptides in smaller yields, in addition to an acyclic analog of F, kahalalide G. The bioassay results of antitumor, antiviral, antimalarial, and OI (activity against AIDS opportunistic infections) tests are reported.
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Citations
Cited by
Medicinal and pharmaceutical uses of seaweed natural products: A review
Smit, A. J. (2004) · Journal of Applied Phycology · doi:10.1023/b:japh.0000047783.36600.ef · Cited by 806
Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
Newman, D. J., & Cragg, G. M. (2004) · Journal of Natural Products · doi:10.1021/np040031y · Cited by 759
Drugs from the deep: Marine natural products as drug candidates
Haefner, B. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02713-2 · Cited by 740
BIOACTIVE PROTEINS, PEPTIDES, AND AMINO ACIDS FROM MACROALGAE1: MACROALGAE: BIOACTIVE AGENT SOURCE
Harnedy, P. A., & FitzGerald, R. J. (2011) · Journal of Phycology · doi:10.1111/j.1529-8817.2011.00969.x · Cited by 393
Natural products as antifungal agents against clinically relevant pathogens
Di Santo, R. (2010) · Natural Product Reports · doi:10.1039/b914961a · Cited by 115
Metadata
- Authors
- Hamann, M. T., Otto, C. S., Scheuer, P. J., & Dunbar, D. C.
- Venue
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1996-01-01
- Volume
- 61
- Issue
- 19
- Pages
- 6594-6600
- ISSN
- 0022-3263 (ISSN-L)
- 1520-6904
- OpenAlex
- W2324491595
- Cited by
- 240
- References
- 0
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Kahalalides: Bioactive Peptides from a Marine Mollusk Elysia rufescens and Its Algal Diet Bryopsis sp. 1. https://app.cochat.ai/papers/10.1021/jo960877+
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- Hamann, M. T., Otto, C. S., Scheuer, P. J., & Dunbar, D. C. (1996). Kahalalides: Bioactive Peptides from a Marine Mollusk Elysia rufescens and Its Algal Diet Bryopsis sp. 1. The Journal of Organic Chemistry. https://doi.org/10.1021/jo960877%2B
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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