Drugs from the deep: Marine natural products as drug candidates

Drugs from the seas - current status and microbiological implications

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REGULATION AND INHIBITION OF PHOSPHOLIPASE A2

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Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent

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Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

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Enantioselective Total Synthesis of Ecteinascidin 743

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Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair

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Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents.

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Synthesis of Ecteinascidin ET-743 and Phthalascidin Pt-650 from Cyanosafracin B

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Evidence for the Biosynthesis of Bryostatins by the Bacterial Symbiont “ Candidatus Endobugula sertula” of the Bryozoan Bugula neritina

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The Microtubule-Stabilizing Agent Discodermolide Competitively Inhibits the Binding of Paclitaxel (Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactions More Potently than Paclitaxel, and Inhibits the Growth of Paclitaxel-Resistant Cells

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Total Synthesis of Bryostatin 2

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Kahalalides: Bioactive Peptides from a Marine Mollusk Elysia rufescens and Its Algal Diet Bryopsis sp. 1

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Synthesis of bryostatin 7

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The Identification and Characterization of the Marine Natural Product Scytonemin as a Novel Antiproliferative Pharmacophore

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Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743

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The chemistry and biology of the bryostatin antitumour macrolides

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Scytonemin-a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases

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Phospholipase A2 Inhibitors from Marine Organisms

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Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways

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AplidinTM Induces Apoptosis in Human Cancer Cells via Glutathione Depletion and Sustained Activation of the Epidermal Growth Factor Receptor, Src, JNK, and p38 MAPK

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Ascosalipyrrolidinone A, an Antimicrobial Alkaloid, from the Obligate Marine Fungus Ascochyta salicorniae

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Aldisine Alkaloids from the Philippine Sponge Stylissa massa Are Potent Inhibitors of Mitogen-Activated Protein Kinase Kinase-1 (MEK-1)

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Mammalian Secreted Phospholipases A2 and Their Pathophysiolo-gical Significance in Inflammatory Diseases

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Novel molecules that interact with microtubules and have functional activity similar to Taxol™

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The Cyanobacterial Origin of Potent Anticancer Agents Originally Isolated from Sea Hares

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Aplidin™ induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C δ

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Ecteinascidin 743: a novel anticancer drug with a unique mechanism of action

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Antiangiogenic activity of aeroplysinin‐1, a brominated compound isolated from a marine sponge

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Functional versus chemical diversity: is biodiversity important for drug discovery?

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Cone venom–from accidental stings to deliberate injection

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The dolastatins, a family of promising antineoplastic agents

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Conotoxins-New Vistas for Peptide Therapeutics

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Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges

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Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paclitaxel in soft tissue sarcoma cells.

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Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: identification of ecteinascidin-743 as a potent cytotoxic agent.

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Effects of Petrosaspongiolide M, a Novel Phospholipase A2 Inhibitor, on Acute and Chronic Inflammation

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Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10

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An evaluation of intrathecal ziconotide for the treatment of chronic pain

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Ecteinascidin-743 inhibits activated but not constitutive transcription.

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Antitumor activity- and gene expression-based profiling of ecteinascidin Et 743 and phthalascidin Pt 650

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Petrosaspongiolides M−R: New Potent and Selective Phospholipase A2 Inhibitors from the New Caledonian Marine Sponge Petrosaspongia nigra

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The clinical development of the bryostatins

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Contignasterol, a highly oxygenated steroid with the unnatural 14.beta. configuration from the marine sponge Petrosia contignata Thiele, 1899

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Marine sponge polyketide inhibitors of protein tyrosine kinase

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A New Tyrosine Kinase Inhibitor from the Marine Brown Alga Stypopodium zonale

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Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1

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Amino Acid Derivatives from the Marine Sponge Jaspis digonoxea

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Overcoming multidrug drug resistance in P-glycoprotein/MDR1-overexpressing cell lines by ecteinascidin 743.

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Manoalide

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Antitumor activity and nucleic acid binding properties of dercitin, a new acridine alkaloid isolated from a marine Dercitus species sponge.

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Variabilin: A Dual Inhibitor of Human Secretory and Cytosolic Phospholipase A2 With Anti-inflammatory Activity

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New Sesquiterpene Derivatives from the Sponge Dysidea Species with a Selective Inhibitor Profile against Human Phospholipase A2 and Other Leukocyte Functions

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The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB.

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The novel cytotoxic sponge metabolite peloruside A, structurally similar to bryostatin-1, has unique bioactivity independent of protein kinase C.

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Synthesis and biological evaluation of aeroplysinin analogues: a new class of receptor tyrosine kinase inhibitors

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Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine.

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Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A2

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Antitumor activity and biochemical effects of topsentin

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The Marine Natural Product, Halistanol Trisulfate, Inhibits pp60v-src Protein Tyrosine Kinase Activity

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Chemical diversity: a function of biodiversity

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ET-743 (PharmaMar/NCI/Ortho Biotech).

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DNA: Still A Target Worth Aiming At?

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Chemical diversity: independent of functional diversity

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A Natural Edge: Nature Still Offers The Greatest Drug Diversity

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Untitled work

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Regioselectiveα-Phosphorylation of Aldoses in Aqueous Solution

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Medicinal and pharmaceutical uses of seaweed natural products: A review

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Marine Natural Products: A Source of Novel Anticancer Drugs

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Discovery of novel metabolites from marine actinomycetes

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Microalgae as Sources of High Added-Value Compounds—A Brief Review of Recent Work

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Response surface methodology optimization of fermentation conditions for rapid and efficient accumulation of macrolactin A by marine Bacillus amyloliquefaciens ESB-2

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In silico comparison of marine, terrestrial and synthetic compounds using ChemGPS-NP for navigating chemical space

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Role of traditional knowledge in marine bioprospecting

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The Biogeography of Marine Invertebrate Life Histories

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Novel database reveals growing prominence of deep-sea life for marine bioprospectingPreprint

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Beyond the beaten path: improving natural products bioprospecting using an eco-evolutionary framework – the case of the octocorals

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Bioprospecting of Marine Invertebrates for New Natural Products — A Chemical and Zoogeographical Perspective

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