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Salicylihalamides A and B, Novel Cytotoxic Macrolides from the Marine Sponge Haliclona sp.
Abstract
Two novel, highly potent, cytotoxic macrolides, salicylihalamides A (1) and B (2), were isolated from the sponge Haliclona sp. This new macrolide class incorporates salicylic acid, a 12-membered lactone ring, and an enamide side chain. COMPARE pattern-recognition analyses of the NCI 60-cell mean graph screening profiles of 1 did not reveal any significant correlations to the profiles of known antitumor compounds in the NCI's "standard agent database", thus supporting the conclusion that the salicylihalamides represent a potentially important new class for antitumor lead optimization and in vivo investigations.
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Cited by
Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
Newman, D. J., & Cragg, G. M. (2004) · Journal of Natural Products · doi:10.1021/np040031y · Cited by 759
Sipkema, D., Franssen, M. C. R., Osinga, R., Tramper, J., & Wijffels, R. H. (2005) · Marine Biotechnology · doi:10.1007/s10126-004-0405-5 · Cited by 420
Selective Induction of Apoptosis with Proton Pump Inhibitor in Gastric Cancer Cells
Yeo, M., Kim, D.-K., Kim, Y.-B., Oh, T. Y., Lee, J.-E., Cho, S. W., Kim, H. C., & Hahm, K.-B. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1065 · Cited by 120
Han, B.-N., Hong, L.-L., Gu, B.-B., Sun, Y.-T., Wang, J., Liu, J.-T., & Lin, H.-W. (2019) · Symbiotic Microbiomes of Coral Reefs Sponges and Corals · doi:10.1007/978-94-024-1612-1_15 · Cited by 39
Metadata
- Authors
- Erickson, K. L., Beutler, J. A., Cardellina, J. H., & Boyd, M. R.
- Venue
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1997-11-01
- Volume
- 62
- Issue
- 23
- Pages
- 8188-8192
- ISSN
- 0022-3263 (ISSN-L)
- 1520-6904
- OpenAlex
- W2089625544
- Cited by
- 255
- References
- 0
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Salicylihalamides A and B, Novel Cytotoxic Macrolides from the Marine Sponge Haliclona sp. https://app.cochat.ai/papers/10.1021/jo971556g
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- Erickson, K. L., Beutler, J. A., Cardellina, J. H., & Boyd, M. R. (1997). Salicylihalamides A and B, Novel Cytotoxic Macrolides from the Marine Sponge Haliclona sp. The Journal of Organic Chemistry. https://doi.org/10.1021/jo971556g
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
