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Cited by 43Antifungal resistance and susceptibilityAntimicrobial agents and applicationsLipid Membrane Structure and Behavior

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Interactions between Cationic Vesicles and Candida albicans

Campanhã, M. T. N., Mamizuka, E. M., Carmona-Ribeiro, A. M.·2001·The Journal of Physical Chemistry B
DOI 10.1021/jp003315+
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Abstract

Dioctadecyldimethylammonium bromide (DODAB), a bilayer-forming synthetic amphiphile with antibacterial properties, also affects viability of Candida albicans. For C. albicans, simultaneous determination of cell viability and electrophoretic mobility as a function of DODAB concentration yields a very good correlation between cell surface charge and cell viability. Upon increasing DODAB concentration, the cell surface charge decreases and changes its sign to yield positively charged cells. However, in contrast to the DODAB bactericidal property, the amphiphile effect on fungus over 1 h of interaction time is only fungistatic at 1 mM DODAB and ca. 10 6 cells/mL. Nevertheless, solubilization of fungicides in DODAB dispersions prepared by sonication causes complete loss of cell viability. Amphotericin B (AB) or miconazole (M) solubilization in the DODAB bilayer leads to 100% cell death, though the drug and DODAB effects are independent. Cell and DODAB bilayer membranes compete for AB or M solubilization with the amphiphile bilayer controlling drug release to the cell membrane. 0.1 mM DODAB plus AB or M concentration of 2 and 20 μg/mL, respectively, yielded 0% of cell viability for C. albicans (2 × 10 6 cells/mL) over an interaction time of 24 h. The cationic liposomes by themselves yielded ca. 20% viability under similar conditions. The full potential of these cytotoxic cationic bilayers to control release and cytotoxicity of drugs remains hitherto unexplored.

Overview

Integrity signals

Registry

Crossref · 10.1021/jp003315+

Cites

29 of 29 references verified0 citation errors · 0 not checkable

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Verification

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Citations

Cites

Research works printed but not linked: 4

  1. Vandeputte J., 1956, Antibiot. Annu., 587
  2. 1908, Reference method for broth dilution antifungal susceptibility testing of yeasts
  3. Bittman R., 1974, Biochemistry, 13, 3
  4. McGinnis M. R., 1991, 3rd. ed., 198

Cited by

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Related

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Metadata

Authors
Campanhã, M. T. N., Mamizuka, E. M., & Carmona-Ribeiro, A. M.
Affiliations
  • Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP 26077, CEP 05513−970 São Paulo SP, Brazil
  • Universidade de São Paulo (BR)
ORCID
Mamizuka, E. M.
Venue
The Journal of Physical Chemistry B
Publisher
American Chemical Society (ACS)
Published
2001-08-01
Volume
105
Issue
34
Pages
8230-8236
ISSN
  • 1520-5207 (ISSN-L)
  • 1520-6106
DOI
10.1021/jp003315+
OpenAlex
W1984677773
Cited by
43
References
29
Citations by year
2025: 1 · 2023: 2 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 1
FWCI
1.77
Type
journal article
Language
en
Open access
closed
Locations
The Journal of Physical Chemistry B (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords
Candida albicans, DODAB, cationic vesicles, cationic liposomes, cell viability, cell surface charge, electrophoretic mobility, fungistatic activity, amphotericin B, miconazole, drug release, antifungal agents

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.