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Proof of Single-Molecule Sensitivity in Surface Enhanced Raman Scattering (SERS) by Means of a Two-Analyte Technique
Abstract
A method is proposed to pin down unambiguous proof for single-molecule sensitivity in surface enhanced Raman spectroscopy (SERS). The simultaneous use of two analyte molecules enables a clear confirmation of the single (or few)-molecule nature of the signals. This method eliminates most of the uncertainties associated with low dye concentrations in previous experiments. It further shows that single- or few-molecule signals are very common in SERS, both in liquids and on dry substrates.
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Citations
Cited by
Guerrini, L., & Graham, D. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35118h · Cited by 441
Rigorous justification of the |E|4 enhancement factor in Surface Enhanced Raman Spectroscopy
Le Ru, E. C., & Etchegoin, P. G. (2006) · Chemical Physics Letters · doi:10.1016/j.cplett.2006.03.042 · Cited by 432
Self-citationLarge-Scale Hot Spot Engineering for Quantitative SERS at the Single-Molecule Scale
Chen, H.-Y., Lin, M.-H., Wang, C.-Y., Chang, Y.-M., & Gwo, S. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b09111 · Cited by 426
Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology
Wang, Y., & Irudayaraj, J. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2012.0026 · Cited by 125
Metadata
- Authors
- Le Ru, E. C., Meyer, M., & Etchegoin, P. G.
- Venue
- The Journal of Physical Chemistry B
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-01-10
- Volume
- 110
- Issue
- 4
- Pages
- 1944-1948
- ISSN
- 1520-5207 (ISSN-L)
- 1520-6106
- OpenAlex
- W2090170839
- Cited by
- 550
- References
- 0
- FWCI
- 14.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Le Ru, E. C., Meyer, M., & Etchegoin, P. G. (2006). Proof of Single-Molecule Sensitivity in Surface Enhanced Raman Scattering (SERS) by Means of a Two-Analyte Technique. The Journal of Physical Chemistry B. https://doi.org/10.1021/jp054732v
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