Violation of Distribution Symmetry in Statistical Evaluation of Absolute Enantioselective Synthesis
Abstract
Enantiomeric excesses obtained in absolute enantioselective synthesis by chiral autocatalysis (Soai-reaction) were statistically analyzed. Two sets of parallel experiments, which were performed under chemically different conditions, are available. One group contains 37, while the other contains 84 preparative results. The former group shows some interesting tendencies but does not give conclusive statistical results. The sample of 84 parallel experiments, providing 39 R- and 45 S-excesses have shown that these data represent two distinct, non-symmetric sets with different non-Gaussian distributions. Clear S preference was found.
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The outcome of the Soai reaction in absence of detectable chiral species is stochastic.
“In addition, the apparent outcome of the Soai reaction performed in the absence of detectable chiral species is stochastic as expected for a truly SMSB process”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [329]
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Buhse, T., Cruz, J.-M., Noble-Terán, M. E., Hochberg, D., Ribó, J. M., Crusats, J., & Micheau, J.-C. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00819 · Cited by 189 · see citing works
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Self-citationElucidation of the Structures of Asymmetric Autocatalyst Based on X-ray Crystallography
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Limits of the Classical Concept of Concentration
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Self-citation
- Authors
- Barabas, B., Caglioti, L., Zucchi, C., Maioli, M., Gál, E., Micskei, K., & Pályi, G.
- Affiliations
- Department of Stochastics, University of Technology and Economics, Müegyetem rkp. 3(H), H-1111 Budapest, Hungary, Department of Chemistry and Technology of Biologically Active Compounds, University “La Sapienza”−Roma, P.le A. Moro 5, I-00185 Roma, Italy, Department of Chemistry, University of Modena and Reggio Emilia, Via Campi 183, I-41100 Modena, Italy, Department of Mathemathics, University of Modena and Reggio Emilia, Via Campi 213, I-41100 Modena, Italy, and Institute of Inorganic and Analytical...
- University of Modena and Reggio Emilia (IT)
- Corresponding author
- Pályi, Gyula
- Venue
- The Journal of Physical Chemistry B
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-09-12
- Volume
- 111
- Issue
- 39
- Pages
- 11506-11510
- ISSN
- 1520-5207 (ISSN-L)
- 1520-6106
- OpenAlex
- W2064752480
- Cited by
- 45
- References
- 5
- Citations by year
- 2023: 1 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Physical Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Physical Sciences › Chemistry › Organic Chemistry › Asymmetric Synthesis and Catalysis
- Physical Sciences › Chemistry › Spectroscopy › Analytical Chemistry and Chromatography
- Keywords
- Soai reaction, enantiomeric excess, non-Gaussian distributions, distribution symmetry, enantioselectivity
- MeSH terms
- Catalysis, Models, Chemical, Stereoisomerism, Models, Statistical
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