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A Single ZnO Nanofiber-Based Highly Sensitive Amperometric Glucose Biosensor
Abstract
A novel fabrication approach of a highly sensitive amperometric glucose biosensor based on a single ZnO nanofiber (ZONF) is presented. Nanofibers (NFs) of poly(vinyl pyrrolidone)/zinc acetate composite have been synthesized by electrospinning technique. By high-temperature calcinations of the above precursor fibers, ZONFs with diameters in the range of 350−195 nm have been successfully obtained. A single NF on a gold electrode is functionalized with glucose oxidase (GOx) by physical adsorption. Electrochemical measurements of the biosensor revealed a high and reproducible sensitivity of 70.2 μA cm −2 mM −1 within a response time of less than 4 s. The biosensor also showed a linear range from 0.25 to 19 mM with a low limit of detection (LOD) of 1 μM. Furthermore, it has been revealed that the biosensor exhibits a good anti-interference ability and favorable stability over relatively long-term storage (more than 4 months). All these results strongly suggest that a single ZONF can provide a new platform for biosensor design and other biological applications.
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Cites
Toward a Glucose Biosensor Based on Surface-Enhanced Raman Scattering
Shafer-Peltier, K. E., Haynes, C. L., Glucksberg, M. R., & Van Duyne, R. P. (2003) · Journal of the American Chemical Society · doi:10.1021/ja028255v · Cited by 653
Cited by
Recent advances in ZnO nanostructures and thin films for biosensor applications: Review
Arya, S. K., Saha, S., Ramirez-Vick, J. E., Gupta, V., Bhansali, S., & Singh, S. P. (2012) · Analytica Chimica Acta · doi:10.1016/j.aca.2012.05.048 · Cited by 579
Wearable flexible sweat sensors for healthcare monitoring: a review
Chung, M., Fortunato, G., & Radacsi, N. (2019) · Journal of The Royal Society Interface · doi:10.1098/rsif.2019.0217 · Cited by 378
Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy
Ding, Y., Li, W., Zhang, F., Liu, Z., Zanjanizadeh Ezazi, N., Liu, D., & Santos, H. A. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201802852 · Cited by 312
Supraja, P., Sudarshan, V., Tripathy, S., Agrawal, A., & Singh, S. G. (2019) · Analytical Methods · doi:10.1039/c8ay02617c · Cited by 45
Metadata
- Authors
- Ahmad, M., Pan, C., Luo, Z., & Zhu, J.
- Venue
- The Journal of Physical Chemistry C
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-05-03
- Volume
- 114
- Issue
- 20
- Pages
- 9308-9313
- ISSN
- 1932-7447 (ISSN-L)
- 1932-7455
- OpenAlex
- W2085096838
- Cited by
- 229
- References
- 1
- FWCI
- 12.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ahmad, M., Pan, C., Luo, Z., & Zhu, J. (2010). A Single ZnO Nanofiber-Based Highly Sensitive Amperometric Glucose Biosensor. The Journal of Physical Chemistry C. https://doi.org/10.1021/jp102505g
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
