Toward a Glucose Biosensor Based on Surface-Enhanced Raman Scattering
Abstract
This work presents the first step toward a glucose biosensor using surface-enhanced Raman spectroscopy (SERS). Historically, glucose has been extremely difficult to detect by SERS because it has a small normal Raman cross section and adsorbs weakly or not at all to bare silver surfaces. In this paper, we report the first systematic study of the direct detection of glucose using SERS. Glucose is partitioned into an alkanethiol monolayer adsorbed on a silver film over nanosphere (AgFON) surface and thereby, it is preconcentrated within the 0-4 nm thick zone of electromagnetic field enhancement. The experiments presented herein utilize leave-one-out partial least-squares (LOO-PLS) analysis to demonstrate quantitative glucose detection both over a large (0-250 mM) and clinically relevant (0-25 mM) concentration range. The root-mean-squared error of prediction (RMSEP) of 1.8 mM (33.1 mg/dL) in the clinical study is near that desired for medical applications (1 mM, 18 mg/dL). Future studies will advance toward true in vivo, real time, minimally invasive sensing.
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Surface enhanced Raman spectroscopy dramatically shortens acquisition times and improves sensitivity and limit of detection.
“Recent advances have demonstrated that surface enhanced Raman spectroscopy (SERS) dramatically decreases acquisition times with concomitant improvements in both sensitivity and limit of detection.45–46”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [45]
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- Authors
- Shafer-Peltier, K. E., Haynes, C. L., Glucksberg, M. R., & Van Duyne, R. P.
- Affiliations
- Contribution from the Department of Biomedical Engineering and Department of Chemistry, Northwestern University Evanston, Illinois 60208-3113
- Northwestern University (US)
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-12-11
- Volume
- 125
- Issue
- 2
- Pages
- 588-593
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2093913522
- Cited by
- 653
- References
- 32
- Citations by year
- 2026: 6 · 2025: 22 · 2024: 21 · 2023: 15 · 2022: 17 · 2021: 25 · 2020: 24 · 2019: 22 · 2018: 34 · 2017: 27 · 2016: 35 · 2015: 52 · 2014: 57 · 2013: 43 · 2012: 46
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ey013002-03)
- National Eye Institute (EY13015, R24EY013015, EY13002)
- Topics
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Engineering › Biomedical Engineering › Plasmonic and Surface Plasmon Research
- Keywords
- glucose biosensor, surface-enhanced Raman scattering, glucose detection, alkanethiol monolayers, electromagnetic field enhancement, partial least squares regression, minimally invasive sensing
- MeSH terms
- Glucose, Silver, Spectrum Analysis, Raman, Biosensing Techniques
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