The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Effects of Salt on the Lower Critical Solution Temperature of Poly (N-Isopropylacrylamide)
Abstract
Classical molecular dynamics simulations were performed to investigate the effects of salt on the lower critical solution temperature (LCST) of Poly (N-isopropylacrylamide) (PNIPAM). PNIPAM is often studied as a protein proxy due to the presence of a peptide bond in its monomer unit. PNIPAM is a temperature sensitive polymer which exhibits hydrophobic-hydrophilic phase transition at its LCST. The presence of salt in the solution will shift its LCST, typically to a lower temperature. This LCST shift follows the so-called Hofmeister series. Molecular dynamics (MD) simulations of PNIPAM in 1 M of NaCl, NaBr, NaI, and KCl were carried out to elucidate the effects of different salt on LCST and protein stability. Our results suggest that direct interactions between the salt cations and the polymer play a critical role in the shift of LCST and subsequently on protein stability. Further, cations have a much stronger affinity with the polymer, whereas anions bind weakly with the polymer. Moreover, the cation-polymer binding affinity is inversely correlated with the cation-anion contact pair association constant in solution.
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Cited by
Li, D., Chen, Y., & Liu, Z. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00013k · Cited by 586
Hofmeister Series: Insights of Ion Specificity from Amphiphilic Assembly and Interface Property
Kang, B., Tang, H., Zhao, Z., & Song, S. (2020) · ACS Omega · doi:10.1021/acsomega.0c00237 · Cited by 444
Moghadam, S., & Larson, R. G. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00942 · Cited by 52
Fehér, B., Zhu, K., Nyström, B., Varga, I., & Pedersen, J. S. (2019) · Langmuir · doi:10.1021/acs.langmuir.9b01896 · Cited by 35
Giesecke, M., Hallberg, F., Fang, Y., Stilbs, P., & Furó, I. (2016) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6b08923 · Cited by 27
Metadata
- Authors
- Du, H., Wickramasinghe, R., & Qian, X.
- Venue
- The Journal of Physical Chemistry B
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-11-22
- Volume
- 114
- Issue
- 49
- Pages
- 16594-16604
- ISSN
- 1520-5207 (ISSN-L)
- 1520-6106
- OpenAlex
- W2007078947
- Cited by
- 278
- References
- 39
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
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