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LSPR Biosensor Signal Enhancement Using Nanoparticle−Antibody Conjugates
Open accessAbstract
A method to amplify the wavelength shift observed from localized surface plasmon resonance (LSPR) bioassays is developed using gold nanoparticle-labeled antibodies. The technique, which involves detecting surface-bound analytes using gold nanoparticle conjugated antibodies, provides a way to enhance LSPR shifts for more sensitive detection of low-concentration analytes. Using the biotin and antibiotin binding pair as a model, we demonstrate up to a 400% amplification of the shift upon antibody binding to analyte. In addition, the antibody-nanoparticle conjugate improves the observed binding constant by 2 orders of magnitude, and the limit of detection by nearly 3 orders of magnitude. This amplification strategy provides a way to improve the sensitivity of plasmon-based bioassays, paving the way for single molecule-based detection and clinically relevant diagnostics.
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Haes, A. J., & Van Duyne, R. P. (2002) · Journal of the American Chemical Society · doi:10.1021/ja020393x · Cited by 2,057
Cited by
Localized surface plasmon resonance: Nanostructures, bioassays and biosensing—A review
Petryayeva, E., & Krull, U. J. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.08.020 · Cited by 1,379
Sapsford, K. E., Tyner, K. M., Dair, B. J., Deschamps, J. R., & Medintz, I. L. (2011) · Analytical Chemistry · doi:10.1021/ac200853a · Cited by 538
Various methods of gold nanoparticles (GNPs) conjugation to antibodies
Jazayeri, M. H., Amani, H., Pourfatollah, A. A., Pazoki-Toroudi, H., & Sedighimoghaddam, B. (2016) · Sensing and Bio-Sensing Research · doi:10.1016/j.sbsr.2016.04.002 · Cited by 528
Nanoplasmonic sensors for biointerfacial science
Jackman, J. A., Rahim Ferhan, A., & Cho, N.-J. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00494f · Cited by 258
Metadata
- Authors
- Hall, W. P., Ngatia, S. N., & Van Duyne, R. P.
- Venue
- The Journal of Physical Chemistry C
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-01-10
- Volume
- 115
- Issue
- 5
- Pages
- 1410-1414
- ISSN
- 1932-7447 (ISSN-L)
- 1932-7455
- OpenAlex
- W1977239238
- Cited by
- 242
- References
- 1
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- green
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