Entropic Stabilization of Proteins by TMAO

Cited by (198)

Items 101–198 of 198

1. Backbone Hydration Determines the Folding Signature of Amino Acid Residues
   Olivier Bignucolo, Hoi Tik Alvin Leung, Stephan Grzesiek, Simon Bernèche · 2015 · Journal of the American Chemical Society
2. Trimethylamine N-oxide: role in cell senescence and age-related diseases
   Lin Zhang, Fang Yu, Jian Xia · 2022 · European Journal of Nutrition
3. Spinocerebellar ataxia-13 Kv3.3 potassium channels: arginine-to-histidine mutations affect both functional and protein expression on the cell surface
   Jian Zhao, Jing Zhu, William B. Thornhill · 2013 · Biochemical Journal
4. Chaperoning protein evolution
   Paolo De Los Rios, Pierre Goloubinoff · 2012 · Nature Chemical Biology
5. Quaternary structure of human small heat shock protein HSPB6 (Hsp20) in crowded media modeled by trimethylamine N-oxide (TMAO): Effect of protein phosphorylation
   Nikolai N. Sluchanko, Natalia A. Chebotareva, Nikolai B. Gusev · 2014 · Biochimie
6. Distinctive behavior and two-dimensional vibrational dynamics of water molecules inside glycine solvation shell
   Aritri Biswas, Bhabani S. Mallik · 2020 · RSC Advances
7. Exploring the role of hydrophilic amino acids in unfolding of protein in aqueous ethanol solution
   Ritaban Halder, Biman Jana · 2020 · Proteins Structure Function and Bioinformatics
8. Effect of urea and glycine betaine on the hydration sphere of model molecules for the surface features of proteins
   Marcin Stasiulewicz, Aneta Panuszko, Maciej Śmiechowski, Piotr Bruździak, Paweł Maszota, Janusz Stangret · 2020 · Journal of Molecular Liquids
9. Liver as a new target organ in Alzheimer’s disease: insight from cholesterol metabolism and its role in amyloid-beta clearance
   Beibei Wu, Yuqing Liu, Hongli Li, Lemei Zhu, Lingfeng Zeng, Zhen Zhang, Weijun Peng · 2023 · Neural Regeneration Research
10. Highly tunable bimane-based fluorescent probes: design, synthesis, and application as a selective amyloid binding dye
    Yarra Venkatesh, Nicholas P. Marotta, Virginia M.‐Y. Lee, E. James Petersson · 2024 · Chemical Science
11. A current perspective on the compensatory effects of urea and methylamine on protein stability and function
    Safikur Rahman, Marina Warepam, Laishram Rajendrakumar Singh, Tanveer Ali Dar · 2015 · Progress in Biophysics and Molecular Biology
12. The effect of aqueous solutions of trimethylamine-N-oxide on pressure induced modifications of hydrophobic interactions
    Rahul Sarma, Sandip Paul · 2012 · The Journal of Chemical Physics
13. Can Urea and Trimethylamine-N-oxide Prevent the Pressure-Induced Phase Transition of Lipid Membrane?
    Archita Maiti, Snehasis Daschakraborty · 2022 · The Journal of Physical Chemistry B
14. Effects of Cosolvents and Crowding Agents on the Stability and Phase Transition Kinetics of the SynGAP/PSD-95 Condensate Model of Postsynaptic Densities
    Hasan Cinar, Rosario Oliva, Haowei Wu, Mingjie Zhang, Hue Sun Chan, Roland Winter · 2022 · The Journal of Physical Chemistry B
15. Factor Defining the Effects of Glycine Betaine on the Thermodynamic Stability and Internal Dynamics of Horse Cytochrome c
    Rishu Jain, Deepak Sharma, Sandeep Kumar, Rajesh Kumar · 2014 · Biochemistry
16. Cosolvent effects on the growth of amyloid fibrils
    Govardhan Reddy, Aswathy N. Muttathukattil, Balaka Mondal · 2020 · Current Opinion in Structural Biology
17. Effects of trimethylamine-N-oxide (TMAO) on aqueous N-methylacetamide solution: A comparison of different force fields of TMAO
    Apramita Chand, Pragin Chettiyankandy, Subrat Kumar Pattanayak, Snehasis Chowdhuri · 2016 · Journal of Molecular Liquids
18. Atomistic level understanding of the stabilization of protein Trp cage in denaturing and mixed osmolyte solutions
    Gargi Borgohain, Sandip Paul · 2018 · Computational and Theoretical Chemistry
19. Small crowder interactions can drive hydrophobic polymer collapse as well as unfolding
    Divya Nayar · 2020 · Physical Chemistry Chemical Physics
20. Mitigation of methanol inactivation of lipases by reaction medium engineering with glycine betaine for enzymatic biodiesel synthesis
    Bhanu Prakash Sandaka, Jitendra Kumar, Jose Savio Melo · 2021 · Fuel
21. Trimethylamine N-Oxide (TMAO): a Unique Counteracting Osmolyte?
    Paul H. Yancey · 2023 · Paracelsus Proceedings of Experimental Medicine
22. Osmolyte Effects on the Growth of Amyloid Fibrils
    Aswathy N. Muttathukattil, Govardhan Reddy · 2016 · The Journal of Physical Chemistry B
23. Hydrophobic association and solvation of neopentane in urea, TMAO and urea–TMAO solutions
    Timir Hajari, Mayank Kumar Dixit, Hari O. S. Yadav · 2022 · Physical Chemistry Chemical Physics
24. Osmolyte-Enhanced Protein Synthesis Activity of a Reconstituted Translation System
    Yoshiki Moriizumi, Kazuhito V. Tabata, Daisuke Miyoshi, Hiroyuki Noji · 2019 · ACS Synthetic Biology
25. Increased plasma trimethylamine- N -oxide levels are associated with mild cognitive impairment in high cardiovascular risk elderly population
    Buawangpong, Nida, Pinyopornpanish, Kanokporn, Phrommintikul, Arintaya, Chindapan, Nathamol, Devahastin, Sakamon, Chattipakorn, Nipon, Chattipakorn, Siriporn C. · 2022 · Food & Function
26. Phase separation propensity of the intrinsically disordered AB region of human RXRβ
    Katarzyna Sołtys, Andrzej Ożyhar · 2023 · Cell Communication and Signaling
27. Pressure, Peptides, and a Piezolyte: Structural Analysis of the Effects of Pressure and Trimethylamine-N-oxide on the Peptide Solvation Shell
    Angelina Folberth, Jakub Polák, Jan Heyda, Nico F. A. van der Vegt · 2020 · The Journal of Physical Chemistry B
28. Role of macromolecular crowding and salt ions on the structural-fluctuation of a highly compact configuration of carbonmonoxycytochrome c
    Rajesh Kumar, Deepak Sharma, Rishu Jain, Sandeep Kumar, Rajesh Kumar · 2015 · Biophysical Chemistry
29. Graph representation of protein free energy landscape
    Minghai Li, Mojie Duan, Jue Fan, Li Han, Shuanghong Huo · 2013 · The Journal of Chemical Physics
30. Mechanism of aggregation of UV-irradiated glycogen phosphorylase b at a low temperature in the presence of crowders and trimethylamine N-oxide
    Tatiana B. Eronina, Valeriya V. Mikhaylova, Natalia A. Chebotareva, Vera A. Borzova, I. K. Yudin, Boris I. Kurganov · 2017 · Biophysical Chemistry
31. TMAO to the rescue of pathogenic protein variants
    Kritika Kumari, Khuraijam Surjalal Singh, Kuldeep Singh, Radhika Bakhshi, Laishram Rajendrakumar Singh · 2022 · Biochimica et Biophysica Acta (BBA) - General Subjects
32. Interactions of S-peptide analogue in aqueous urea and trimethylamine- N -oxide solutions: A molecular dynamics simulation study
    Rahul Sarma, Sandip Paul · 2013 · The Journal of Chemical Physics
33. Liquid-liquid phase separation of the intrinsically disordered AB region of hRXRγ is driven by hydrophobic interactions
    Katarzyna Sołtys, Krzysztof Wycisk, Andrzej Ożyhar · 2021 · International Journal of Biological Macromolecules
34. Why does TMAO stabilize the globule state of PNIPAM?
    Andrea Pica, Giuseppe Graziano · 2017 · Polymer
35. Enhanced stability of kinesin-1 as a function of temperature
    Katelyn J. Chase, Florence Doval, Michael D. Vershinin · 2017 · Biochemical and Biophysical Research Communications
36. Effect of cosolvents in the preferential binding affinity of water in aqueous solutions of amino acids and amides
    Dilip.H.N., Debashree Chakraborty · 2019 · Journal of Molecular Liquids
37. On the Correlation between Pair Hydrophobicity and Mixing Enthalpies in Water–Alcohol Binary Mixtures
    Ritaban Halder, Biman Jana · 2020 · The Journal of Physical Chemistry B
38. Hydration of Simple Model Peptides in Aqueous Osmolyte Solutions
    Aneta Panuszko, Maciej Pieloszczyk, Anna Kuffel, Karol Jacek, Karol A. Biernacki, Sebastian Demkowicz, Janusz Stangret, Piotr Bruździak · 2021 · International Journal of Molecular Sciences
39. Enzymatically Produced Trimethylamine N-Oxide: Conserving It or Eliminating It
    Gianluca Catucci, Giulia Querio, Sheila J. Sadeghi, Gianfranco Gilardi, Renzo Cesare Levi · 2019 · Catalysts
40. Structure and Orientation of Water and Choline Chloride Molecules around a Methane Hydrophobe: A Computer Simulation Study
    Pooja Nanavare, Asha Rani Choudhury, Soham Sarkar, Atanu Maity, Rajarshi Chakrabarti · 2022 · ChemPhysChem
41. Trimethylamine oxide induces pyroptosis of vascular endothelial cells through ALDH2/ROS/NLRP3/GSDMD pathway.
    Jialing Li, Hongwei Lü, Shuhua Chen, Hong Xiang, Hengdao Liu, Shaoli Zhao · 2022 · PubMed Central
42. Thermodynamic Driving Forces for Dye Molecule Position and Orientation in Nanoconfined Solvents
    Jacob Harvey, Ward H. Thompson · 2014 · The Journal of Physical Chemistry B
43. Temperature-mediated switching of protectant-denaturant behavior of trimethylamine-N-oxide and consequences on protein stability from a replica exchange molecular dynamics simulation study
    Gargi Borgohain, Sandip Paul · 2016 · Molecular Simulation
44. Effect of nonpolar confinement on protein Trp cage conformation in aqueous osmolyte solutions
    Gargi Borgohain, Sandip Paul · 2017 · Journal of Molecular Liquids
45. Assessing the role of osmolytes on the conformational harmony of islet amyloid polypeptide
    Anchala Kumari, Ritika Sharma, Pallavi Somvanshi, Abhinav Grover · 2020 · International Journal of Biological Macromolecules
46. A new force field including charge directionality for TMAO in aqueous solution
    Kota Usui, Yuki Nagata, Johannes Hunger, Mischa Bonn, Marialore Sulpizi · 2016 · The Journal of Chemical Physics
47. Folding/unfolding of protein Trp cage in aqueous osmolyte solutions under polar confinement
    Gargi Borgohain, Sandip Paul · 2017 · Journal of Molecular Liquids
48. Density variations of TMAO solutions in the kilobar range: Experiments, PC-SAFT predictions, and molecular dynamics simulations
    Michael Knierbein, Christoph Held, Christoph Hölzl, Dominik Horinek, Michael Paulus, Gabriele Sadowski, Christian Sternemann, Julia Nase · 2019 · Biophysical Chemistry
49. A computational approach to get insights into multiple faces of additives in modulation of protein aggregation pathways
    Nidhi Malhotra, Shashank Deep · 2019 · Physical Chemistry Chemical Physics
50. Probing the Conformational Ensemble of the Amyloid Beta 16–22 Fragment with Parallel-Bias Metadynamics
    Timur I. Magsumov, Ilya Ibraev, Igor A. Sedov · 2024 · The Journal of Physical Chemistry B
51. A study of the interaction between TMAO and urea in water using NMR spectroscopy
    Mazin Nasralla, Harrison Laurent, Daniel L. Baker, Michael Edward Ries, Lorna Dougan · 2022 · Physical Chemistry Chemical Physics
52. Basket-type G-quadruplex with two tetrads in the presence of TMAO and urea: A molecular dynamics study
    Ewa Anna Oprzeska‐Zingrebe, Jens Smiatek · 2022 · Journal of Molecular Structure
53. The protein-stabilizing effects of TMAO in aqueous and non-aqueous conditions
    Hassan Monhemi, Hai Nam Hoang, Daron M. Standley, Tomoko Matsuda, Mohammad Reza Housaindokht · 2022 · Physical Chemistry Chemical Physics
54. Thermodynamic properties of aqueous osmolyte solutions at high-pressure conditions
    Michael Knierbein, Maximilian Venhuis, Christoph Held, Gabriele Sadowski · 2019 · Biophysical Chemistry
55. On the ability of trehalose to offset the denaturing activity of urea
    Giuseppe Graziano · 2012 · Chemical Physics Letters
56. Structurally different chemical chaperones show similar mechanical roles with independent molecular mechanisms
    Deep Chaudhuri, Debojyoti Chowdhury, Soham Chakraborty, Madhu Bhatt, Rudranil Chowdhury, Aakashdeep Dutta, Ayush Mistry, Shubhasis Haldar · 2024 · Nanoscale
57. Biotechnological Improvements of Cold-Adapted Enzymes: Commercialization via an Integrated Approach
    Khawar Sohail Siddiqui, Ahsan Mushir Shemsi, Gea Guerriero, Tahria Najnin, Taha, Haluk Ertan · 2017 · Springer eBooks
58. Effect of TMAO and Urea on Dimers and Tetramers of Amyloidogenic Heptapeptides (23FGAILSS29)
    Ashma Khan, Shahid M. Nayeem · 2020 · ACS Omega
59. Toward Extreme Biophysics: Deciphering the Infrared Response of Biomolecular Solutions at High Pressures
    Sho Imoto, Patrick Kibies, Christopher Rosin, Roland Winter, Stefan Michael Kast, Dominik Marx · 2016 · Angewandte Chemie
60. The role of molecular interactions on Michaelis constants of α-chymotrypsin catalyzed peptide hydrolyses
    Michael Knierbein, Christoph Held, Gabriele Sadowski · 2020 · The Journal of Chemical Thermodynamics
61. Determinants for Sugar-Induced modulation of thermodynamic stability of lysozyme
    Sandeep Kumar, Kiranjot Kaur, Saraboji Kadhirvel, Rajesh Kumar · 2024 · Journal of Molecular Liquids
62. Effects of Pressure and Osmolytes on the Allosteric Equilibria of Salmonella typhimurium Tryptophan Synthase
    Robert S. Phillips, Alexandre Kim Wang, Stéphane Marchal, Reinhard Lange · 2012 · Biochemistry
63. Interaction studies of Gut metabolite; Trimethylene amine Oxide with Bovine Serum Albumin through Spectroscopic, DFT and Molecular Docking Approach
    Awadhesh Kumar Verma, Payal Gulati, GBVS Lakshmi, Pratima Rathee Solanki, Anil Kumar · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
64. Osmolyte-induced conformational stabilization of a hydrophobic polymer
    Pooja Nanavare, Soham Sarkar, Abhijit Bijay Jena, Rajarshi Chakrabarti · 2024 · Physical Chemistry Chemical Physics
65. Temperature-Dependent Trimethylamine N -Oxide Induced the Formation of Substance P Dimers
    Carter Lantz, Zhenyu Xi, Robert L. Rider, Thomas E. Walker, Michael J. Hebert, David H. Russell · 2024 · The Journal of Physical Chemistry B
66. Dynamics of a methane hydrophobe in aqueous choline chloride solution: Insights from molecular dynamics simulations
    Pooja Nanavare, Ligesh Theeyancheri, Soham Sarkar, Rajarshi Chakrabarti · 2023 · Chemical Physics Impact
67. Contrasting behavior of urea in strengthening and weakening confinement effects on polymer collapse
    Alen James, Divya Nayar · 2024 · The Journal of Chemical Physics
68. TMAO Destabilizes RNA Secondary Structure via Direct Hydrogen Bond Interactions
    Samuel S. Cho, Adam T. Green, Changbong Hyeon, Dave Thirumalai · 2023 · The Journal of Physical Chemistry B
69. Roles of TMAOase in muscle and drips of Alaska pollock fillets at various freeze/thaw cycles
    Jinhwan Lee, Jae W. Park · 2017 · Journal of Food Processing and Preservation
70. Role of TMAO on Folding Behavior of Various Proteins Associated with Neurodegeneration
    Kritika Kumari · 2024 · Springer eBooks
71. Unveiling the effect of choline chloride on hydrophobic association of methane
    Pooja Nanavare, Rajarshi Chakrabarti · 2025 · Physical Chemistry Chemical Physics
72. Dynamics of Loop Formation in Active Chains
    Debarati Sarkar, Abhishekamole Brahmanandan, Snigdha Thakur · 2015 · Macromolecular Symposia
73. Regulation of Host Chromatin by Bacterial Metabolites
    Sridhar Mani · 2016 · Elsevier eBooks
74. Understanding the role of short- and long-range intermolecular interactions in novel computational drug discovery
    Samuel S. Cho, Akbar Salam · 2025 · Expert Opinion on Drug Discovery
75. Raman spectroscopic, computational, and X-ray crystallographic investigation of intermolecular interactions in trimethylamine N-oxide (TMAO) and TMAO-d9
    Louis E. McNamara, Ethan C. Lambert, Dana N. Reinemann, Henry U. Valle, T. Keith Hollis, Gregory S. Tschumper, Nathan I. Hammer · 2022 · Chemical Physics Letters
76. Small organic osmolytes accelerate actin filament assembly and stiffen filaments
    Bryan Demosthene, Pavlo Kravchuk, Connor L. Harmon, Abdulrazak Kalae, Hyeran Kang · 2024 · Cytoskeleton
77. Restoration of structural stability and ligand binding after removal of the conserved disulfide bond in tear lipocalin
    Oktay K. Gasymov, Adil R. Abduragimov, Ben J. Glasgow · 2014 · Biochemical and Biophysical Research Communications
78. Osmolytes Offset the Urea’s Effect on Protein Structure and Function
    Safikur Rahman, Jihyun Park, Jihoe Kim · 2017 · Springer eBooks
79. Unifying the Ambivalent Mechanisms of Protein-Stabilising Osmolytes
    Mrinmoy Mukherjee, Jagannath Mondal · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
80. Molecular Insights into Osmolyte‐Mediated Adaptation of Lipid Membrane of Extremophiles
    Nirupma Rani, Venkatesh Nagaraj, Snehasis Daschakraborty · 2025 · Chemistry - An Asian Journal
81. Dynamics of the Myoglobin/Heme Complex: A Limited Proteolysis Perspective
    Carter Lantz, Leila Minian, Roza Avetisyan, Zhenyu Xi, David H. Russell · 2026 · ACS Measurement Science Au
82. Modulation of the Sliding Movement of Myosin-Driven Actin Filaments Associated with Their Distortion: The Effect of ATP, ADP, and Inorganic Phosphate
    Kuniyuki Hatori, Satoru Kikuchi · 2018 · Springer eBooks
83. Possible cold-adaptation for the fungal kinesin in compensation for thermal stability acquired by single amino acid substitution
    Youské Shimizu, Toru Togawa, Shigeru Chaen · 2018 · The Journal of Biochemistry
84. A quantum chemical study on the hydration energetics of trimethylamine N-oxide, its protonated form and tert-butanol
    Orlando Crescenzi, Giuseppe Graziano · 2022 · Chemical Physics Letters
85. Effect of Cosolutes on the Aggregation of a Tau Fragment: A Combined Experimental and Simulation Approach
    Andrea Arsiccio, Xikun Liu, Pritam Ganguly, Steven K. Buratto, Michael T. Bowers, Joan‐Emma Shea · 2023 · The Journal of Physical Chemistry B
86. Physicochemical Properties of Frozen Fish Muscle as Affected by Trimethylamine-N-oxide demethylase (TMAOase)
    Jinhwan Lee · 2016
87. Recruiting Unfolding Chaperones to Solubilize Misfolded Recombinant Proteins
    Rayees U.H. Mattoo, Pierre Goloubinoff · 2014
88. Towards Measuring Hydrophobic Hydration at Small and Large Scales
    Duncan Halverson · 2017 · TSpace (University of Toronto)
89. Influence of Cosolvents on the Pressure Stability of Human Serum Albumin
    Jaqueline Savelkouls, Eric Schneider, Chang Hee Woo, Michael Paulus · 2024 · physica status solidi (a)
90. Size-dependent desolvation of hydrophobic nanoparticles in aqueous osmolytes
    Bing Fang, Guochao Sun, Yuanyuan Qu, Yongqiang Li, Xiangdong Liu, Yanmei Yang, Weifeng Li · 2025 · Physical Chemistry Chemical Physics
91. Infrared measurements of protein conformational dynamics
    Robert M. Culik · 2014 · ScholarlyCommons (University of Pennsylvania)
92. Additional file 1 of Phase separation propensity of the intrinsically disordered AB region of human RXRβ
    Katarzyna Sołtys, Andrzej Ożyhar · 2023 · Figshare
93. Additional file 2 of Phase separation propensity of the intrinsically disordered AB region of human RXRβ
    Katarzyna Sołtys, Andrzej Ożyhar · 2023 · Figshare
94. Faunal turnover and spatial structuring of Pseudotanaidae (Crustacea; Tanaidacea) in the North Pacific deep sea
    Aleksandra Jakiel, Magdalena Błażewicz · 2026 · Progress In Oceanography
95. Reshaping the folding landscape of the N-terminal Src homology 3 domain of the Drosophila adapter protein Drk with ionic liquids
    Micael S. Silva, Aldino Viegas, Philip O’Toole, Sara S. Félix, Angelo Miguel Figueiredo, Eurico J. Cabrita · 2026 · International Journal of Biological Macromolecules
96. A Density Functional Theory Study on Trimethylamine N ‐Oxide Interactions with Amino Acid Side Chain Models: Probing the Driving Force of Lysozyme Aggregation
    Przemysław Pastwa, Aneta Panuszko, Agnieszka Pladzyk, Piotr Bruździak · 2026 · ChemPhysChem
97. Hydrophobic Association in Urea–Water Solutions: A Structural and Thermodynamic Perspective
    Timir Hajari, Mayank Kumar Dixit, Takashi Taniguchi · 2026 · The Journal of Physical Chemistry B
98. Transcriptomic insight into the different adaptation strategies of piezophilic and piezotolerant bacteria to high hydrostatic pressure
    Jiahua Wang, Xin Hu, Tianqiang Bao, Jie Liu, Hongcai Zhang, Huifang Luo, Junwei Cao, Li Zhang, Xi Yu, Jiasong Fang · 2026 · Elsevier eBooks