Increased plasma trimethylamine- N -oxide levels are associated with mild cognitive impairment in high cardiovascular risk elderly population
Abstract
Plasma TMAO increased in patients with CV risk who had mild cognitive impairment. TMAO may serve as a potential biomarker for the early stages of cognitive impairment in patients with CV risk, and for MCI in patients with CV risk.
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TMAO levels are elevated in plasma and cerebrospinal fluid of individuals with mild cognitive impairment and Alzheimer's disease, and TMAO can traverse the blood-brain barrier and contribute to neurodegeneration by inducing microglial and astrocytic activation.
“Importantly, elevated levels of TMAO have been observed in the plasma and cerebrospinal fluid (CSF) of individuals with MCI and AD.409,410 Several studies have shown that TMAO has the ability to traverse the BBB and contribute to neurodegeneration by inducing microglial and astrocytic activation.411–414”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [409]
Elevated levels of TMAO have been reported in the plasma and CSF of individuals with MCI, AD, and PD.
“Studies have reported elevated levels of TMAO in the plasma and CSF of individuals with MCI, AD, and PD.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [409]
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In vivo mechanism of the interaction between trimethylamine lyase expression and glycolytic pathways
Li, Q., Wu, D., Song, Y., Zhang, L., Wang, T., Chen, X., & Zhang, M. (2024) · Food & Function · doi:10.1039/d4fo03809f · Cited by 3 · see citing works
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Roy, A., Roy, R., Bhattacharya, P., & Borah, A. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00050 · Cited by 6 · see citing works
Gupta, D. K., & Kumar, R. (2026) · Cureus · doi:10.7759/cureus.103206 · Cited by 1 · see citing works
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Chen, X., Ma, K., Shi, Y., Li, Y., Ji, Y., & Liu, Y. (2026) · Microorganisms · doi:10.3390/microorganisms14061356
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- Authors
- Buawangpong, N., Pinyopornpanish, K., Phrommintikul, A., Chindapan, N., Devahastin, S., Chattipakorn, N., & Chattipakorn, S. C.
- Affiliations
- Chiang Mai University (TH)
- Siam University (TH)
- Office of the Royal Society (TH)
- Corresponding author
- Chattipakorn, Siriporn C.
- ORCID
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Volume
- 13
- Issue
- 19
- Pages
- 10013-10022
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W4294865074
- Cited by
- 12
- References
- 85
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Higher Education, Science, Research and Innovation, Thailand (RGNS 64 - 066 (NB))
- Chiang Mai University (CMU Excellent Center award (NC))
- Thailand Research Fund (RTA 6180008 (SD))
- National Research Council of Thailand (Senior Research Scholar Grant (SCC))
- National Science and Technology Development Agency (NSTDA Research Chair grant (NC))
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- trimethylamine N-oxide, mild cognitive impairment, plasma biomarkers, cardiovascular risk, older adults, metabolic syndrome, cardiovascular disease, risk prediction
- MeSH terms
- Heart Disease Risk Factors, Aged, Blood Glucose, Cardiovascular Diseases, Humans, Lipids, Methylamines, Middle Aged, Oxides, Risk Factors, Biomarkers, Cognitive Dysfunction
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