The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
The Most Effective Gold Nanorod Size for Plasmonic Photothermal Therapy: Theory and In Vitro Experiments
Open accessAbstract
The development of new and improved photothermal contrast agents for the successful treatment of cancer (or other diseases) via plasmonic photothermal therapy (PPTT) is a crucial part of the application of nanotechnology in medicine. Gold nanorods (AuNRs) have been found to be the most effective photothermal contrast agents, both in vitro and in vivo. Therefore, determining the optimum AuNR size needed for applications in PPTT is of great interest. In the present work, we utilized theoretical calculations as well as experimental techniques in vitro to determine this optimum AuNR size by comparing plasmonic properties and the efficacy as photothermal contrast agents of three different sizes of AuNRs. Our theoretical calculations showed that the contribution of absorbance to the total extinction, the electric field, and the distance at which this field extends away from the nanoparticle surface all govern the effectiveness of the amount of heat these particles generate upon NIR laser irradiation. Comparing between three different AuNRs (38 × 11, 28 × 8, and 17 × 5 nm), we determined that the 28 × 8 nm AuNR is the most effective in plasmonic photothermal heat generation. These results encouraged us to carry out in vitro experiments to compare the PPTT efficacy of the different sized AuNRs. The 28 × 8 nm AuNR was found to be the most effective photothermal contrast agent for PPTT of human oral squamous cell carcinoma. This size AuNR has the best compromise between the total amount of light absorbed and the fraction of which is converted to heat. In addition, the distance at which the electric field extends from the particle surface is most ideal for this size AuNR, as it is sufficient to allow for coupling between the fields of adjacent particles in solution (i.e., particle aggregates), resulting in effective heating in solution.
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Cites
Optical Constants of the Noble Metals
Johnson, P. B., & Christy, R. W. (1972) · Physical Review B · doi:10.1103/physrevb.6.4370 · Cited by 20,094
Kelly, K. L., Coronado, E., Zhao, L. L., & Schatz, G. C. (2003) · The Journal of Physical Chemistry B · doi:10.1021/jp026731y · Cited by 10,594
Chemistry and Properties of Nanocrystals of Different Shapes
Burda, C., Chen, X., Narayanan, R., & El-Sayed, M. A. (2005) · Chemical Reviews · doi:10.1021/cr030063a · Cited by 7,230
Self-citationCancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods
Huang, X., El-Sayed, I. H., Qian, W., & El-Sayed, M. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057254a · Cited by 5,436
Self-citationPreparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method
Nikoobakht, B., & El-Sayed, M. A. (2003) · Chemistry of Materials · doi:10.1021/cm020732l · Cited by 5,069
Self-citationJain, P. K., Lee, K. S., El-Sayed, I. H., & El-Sayed, M. A. (2006) · The Journal of Physical Chemistry B · doi:10.1021/jp057170o · Cited by 4,603
Self-citationJain, P. K., Huang, X., El-Sayed, I. H., & El-Sayed, M. A. (2008) · Accounts of Chemical Research · doi:10.1021/ar7002804 · Cited by 4,215
Self-citationNanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Hirsch, L. R., Stafford, R. J., Bankson, J. A., Sershen, S. R., Rivera, B., Price, R. E., Hazle, J. D., Halas, N. J., & West, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232479100 · Cited by 3,955
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
Discrete-Dipole Approximation For Scattering Calculations
Draine, B. T., & Flatau, P. J. (1994) · Journal of the Optical Society of America A · doi:10.1364/josaa.11.001491 · Cited by 3,614
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The Effect of Nanoparticle Size on In Vivo Pharmacokinetics and Cellular Interaction
Hoshyar, N., Gray, S., Han, H., & Bao, G. (2016) · Nanomedicine · doi:10.2217/nnm.16.5 · Cited by 1,990
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Elahi, N., Kamali, M., & Baghersad, M. H. (2018) · Talanta · doi:10.1016/j.talanta.2018.02.088 · Cited by 1,174
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Abadeer, N. S., & Murphy, C. J. (2016) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.5b11232 · Cited by 919
Riley, R. S., & Day, E. S. (2017) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1449 · Cited by 801
Hang, Y., Wang, A., & Wu, N. (2024) · Chemical Society Reviews · doi:10.1039/d3cs00793f · Cited by 473
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Baffou, G., Cichos, F., & Quidant, R. (2020) · Nature Materials · doi:10.1038/s41563-020-0740-6 · Cited by 470
Nanocatalysis: size- and shape-dependent chemisorption and catalytic reactivity
Roldan Cuenya, B., & Behafarid, F. (2015) · Surface Science Reports · doi:10.1016/j.surfrep.2015.01.001 · Cited by 388
Zhang, Y., Zhan, X., Xiong, J., Peng, S., Huang, W., Joshi, R., Cai, Y., Liu, Y., Li, R., Yuan, K., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26978-1 · Cited by 348
Gold-Nanoparticle-Assisted Plasmonic Photothermal Therapy Advances Toward Clinical Application
Ali, M. R. K., Wu, Y., & El-Sayed, M. A. (2019) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.9b01961 · Cited by 346
Self-citationAli, M. R. K., Rahman, M. A., Wu, Y., Han, T., Peng, X., Mackey, M. A., Wang, D., Shin, H. J., Chen, Z. G., Xiao, H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619302114 · Cited by 319
Self-citationSakore, P., Bhattacharya, S., Belemkar, S., Prajapati, B. G., & Elossaily, G. M. (2024) · Results in Chemistry · doi:10.1016/j.rechem.2023.101264 · Cited by 64
Metadata
- Authors
- Mackey, M. A., Ali, M. R. K., Austin, L. A., Near, R. D., & El-Sayed, M. A.
- Venue
- The Journal of Physical Chemistry B
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-01-23
- Volume
- 118
- Issue
- 5
- Pages
- 1319-1326
- ISSN
- 1520-5207 (ISSN-L)
- 1520-6106
- OpenAlex
- W2315279405
- Cited by
- 391
- References
- 43
- FWCI
- 18.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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