The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice
Open accessAbstract
Significance: This is a systematic in vivo study of gold nanorods (AuNRs)-assisted plasmonic photothermal therapy (AuNRs-PPTT) for cancer. We have optimized the properties of our AuNRs and the conditions of PPTT to achieve maximal induction of tumor apoptosis. To examine the molecular mechanisms of action of AuNRs-PPTT, we used quantitative proteomics to study protein expression levels in mouse tumor tissues and found the apoptosis pathway to be significantly perturbed. We report a long-term toxicity study (up to 15 months in the mouse model) that showed no toxicity of the AuNRs. Together, these data suggest that our AuNRs-PPTT has potential as an approach to cancer therapy.
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Cites
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Self-citationAnalysis of nanoparticle delivery to tumours
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Cited by
Recent biomedical applications of gold nanoparticles: A review
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Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073
Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer
Singh, P., Pandit, S., Mokkapati, V. R. S. S., Garg, A., Ravikumar, V., & Mijakovic, I. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071979 · Cited by 1,038
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Metadata
- Authors
- Ali, M. R. K., Rahman, M. A., Wu, Y., Han, T., Peng, X., Mackey, M. A., Wang, D., Shin, H. J., Chen, Z. G., Xiao, H., Wu, R., Tang, Y., Shin, D. M., & El-Sayed, M. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-03-29
- Volume
- 114
- Issue
- 15
- Pages
- E3110-E3118
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2603681984
- Cited by
- 319
- References
- 78
- FWCI
- 15.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Ali, M. R. K., Rahman, M. A., Wu, Y., Han, T., Peng, X., Mackey, M. A., Wang, D., Shin, H. J., Chen, Z. G., Xiao, H., Wu, R., Tang, Y., Shin, D. M., & El-Sayed, M. A. (2017). Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1619302114
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