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Molecular Analysis of Drug Delivery Systems Controlled by Dissolution of the Polymer Carrier
Abstract
Dissolution-controlled drug delivery systems are characterized by a phase erosion of the polymer carrier that is associated with fast or slow dissolution of the macromolecular chains. The molecular nature of the dissolution phenomenon was examined by analyzing the water transport process and the subsequent polymer chain disentanglement that is usually characterized by a snake-like motion of the chain (reptation). The results indicate that the polymer molecular weight, water, polymer and drug diffusion coefficients, equilibrium water concentration in the polymer, and water-polymer interaction parameter can control the mechanism and rate of drug release. A new model for this process was developed, and its predictions are compared with experimental studies of drug delivery from poly(vinyl alcohol)-based systems.
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Citations
Cited by
Hydrogels in pharmaceutical formulations
Peppas, N. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00090-4 · Cited by 4,011
Self-citationKamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070
Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC)
Siepmann, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00112-0 · Cited by 2,613
Mathematical modeling of drug delivery
Siepmann, J., & Siepmann, F. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.09.004 · Cited by 1,363
Fu, Y., & Kao, W. J. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425241003602259 · Cited by 1,305
A review of polymer dissolution
Miller-Chou, B. A., & Koenig, J. L. (2003) · Progress in Polymer Science · doi:10.1016/s0079-6700(03)00045-5 · Cited by 1,115
Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC)
Siepmann, J., & Peppas, N. A. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.028 · Cited by 1,021
Self-citationArifin, D. Y., Lee, L. Y., & Wang, C.-H. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.007 · Cited by 674
Singh, A., Dhiman, N., Kar, A. K., Singh, D., Purohit, M. P., Ghosh, D., & Patnaik, S. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121525 · Cited by 537
Fonseca-Santos, B., & Chorilli, M. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2017.03.198 · Cited by 266
Effect of drug type on the degradation rate of PLGA matrices
SIEGEL, S., KAHN, J., METZGER, K., WINEY, K., WERNER, K., & DAN, N. (2006) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2006.06.009 · Cited by 208
Raman, C., Berkland, C., Kim, K. (., & Pack, D. W. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.11.012 · Cited by 166
Metadata
- Authors
- Narasimhan, B., & Peppas, N. A.
- Venue
- Journal of Pharmaceutical Sciences
- Publisher
- American Geophysical Union (AGU)
- Published
- 1997-03
- Volume
- 86
- Issue
- 3
- Pages
- 297-304
- ISSN
- 0022-3549 (ISSN-L)
- OpenAlex
- W2021327126
- Cited by
- 190
- References
- 0
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- closed
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