Hydrogels in pharmaceutical formulations
Abstract
The availability of large molecular weight protein- and peptide-based drugs due to the recent advances in the field of molecular biology has given us new ways to treat a number of diseases. Synthetic hydrogels offer a possibly effective and convenient way to administer these compounds. Hydrogels are hydrophilic, three-dimensional networks, which are able to imbibe large amounts of water or biological fluids, and thus resemble, to a large extent, a biological tissue. They are insoluble due to the presence of chemical (tie-points, junctions) and/or physical crosslinks such as entanglements and crystallites. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as pH, ionic strength and temperature. The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.
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In situ gelation of hydrogels is the prime factor in their success as a drug delivery vehicle.
“In situ gelation of hydrogels is the prime factor in their success as a drug delivery vehicle.250”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [250]
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Structure and Swelling Behavior of Poly(Ethylene Glycol)/Poly(Methacrylic Acid) Complexes
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Self-citationAra-C release from poly(acrylamide-co-monomethyl itaconate) hydrogels: in vitro and in vivo studies
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Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
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Is it time to start transitioning from 2D to 3D cell culture?
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- Authors
- Peppas, N.
- Affiliations
- Purdue University West Lafayette (US)
- Corresponding author
- Peppas, N
- ORCID
- Peppas, N
- Venue
- European Journal of Pharmaceutics and Biopharmaceutics
- Publisher
- Elsevier BV
- Published
- 2000-07-03
- Volume
- 50
- Issue
- 1
- Pages
- 27-46
- ISSN
- 0939-6411 (ISSN-L)
- OpenAlex
- W2082511674
- Cited by
- 4,011
- References
- 160
- Citations by year
- 2026: 177 · 2025: 181 · 2024: 139 · 2023: 167 · 2022: 181 · 2021: 214 · 2020: 204 · 2019: 247 · 2018: 226 · 2017: 224 · 2016: 186 · 2015: 216 · 2014: 207 · 2013: 207 · 2012: 175
- FWCI
- 17.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm056231-02)
- National Institute of General Medical Sciences (GM-43337, GM 56231, R01GM043337)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Keywords
- hydrogels, drug formulation, protein and peptide drugs, drug delivery, stimuli-responsive hydrogels, hydrogel characterization, drug release, crosslinking, hydrogel networks
- MeSH terms
- Animals, Chemistry, Pharmaceutical, Chemistry, Physical, Humans, Pharmacokinetics, Drug Delivery Systems, Hydrogels, Chemical Phenomena
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