Cited by 4,011Hydrogels: synthesis, properties, applicationsAdvanced Drug Delivery SystemsSupramolecular Self-Assembly in Materials

Hydrogels in pharmaceutical formulations

Peppas, N·2000·European Journal of Pharmaceutics and Biopharmaceutics

Abstract

The availability of large molecular weight protein- and peptide-based drugs due to the recent advances in the field of molecular biology has given us new ways to treat a number of diseases. Synthetic hydrogels offer a possibly effective and convenient way to administer these compounds. Hydrogels are hydrophilic, three-dimensional networks, which are able to imbibe large amounts of water or biological fluids, and thus resemble, to a large extent, a biological tissue. They are insoluble due to the presence of chemical (tie-points, junctions) and/or physical crosslinks such as entanglements and crystallites. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as pH, ionic strength and temperature. The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.

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Crossref · 10.1016/s0939-6411(00)00090-4

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160 of 160 references verified0 citation errors · 0 not checkable

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Authors
Peppas, N.
Affiliations
Purdue University West Lafayette (US)
Corresponding author
Peppas, N
Venue
European Journal of Pharmaceutics and Biopharmaceutics
Publisher
Elsevier BV
Published
2000-07-03
Volume
50
Issue
1
Pages
27-46
ISSN
0939-6411 (ISSN-L)
OpenAlex
W2082511674
Cited by
4,011
References
160
Citations by year
2026: 177 · 2025: 181 · 2024: 139 · 2023: 167 · 2022: 181 · 2021: 214 · 2020: 204 · 2019: 247 · 2018: 226 · 2017: 224 · 2016: 186 · 2015: 216 · 2014: 207 · 2013: 207 · 2012: 175
FWCI
17.57
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01gm056231-02)
  • National Institute of General Medical Sciences (GM-43337, GM 56231, R01GM043337)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
Keywords
hydrogels, drug formulation, protein and peptide drugs, drug delivery, stimuli-responsive hydrogels, hydrogel characterization, drug release, crosslinking, hydrogel networks
MeSH terms
Animals, Chemistry, Pharmaceutical, Chemistry, Physical, Humans, Pharmacokinetics, Drug Delivery Systems, Hydrogels, Chemical Phenomena

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